Has anyone heard about this peptide before? Sounds promising as it’s orally active. https://onlinelibrary.wiley.com/doi/10.1002/dmrr.70056

Everyone wants to crank the GH dial. I get it. But if the “amp” (your terrain) is noisy insulin resistance, chronic inflammation, sluggish thyroid, chaotic sleep you’re just amplifying distortion. The biology is straightforward: outcomes are receptor-limited, terrain-dependent, and circadian-coded. Fix the signal, then turn up the volume. Let’s clear two myths fast so we don’t build on sand. First, BPC-157 has only shown growth-hormone-receptor upregulation in rat tendon cells in a dish. That’s a clue for tendons in vitro, not a green light to claim gut, fat, muscle, or human receptor changes. Second, GH’s fat-loss effect is systemic. Putting shots in the belly doesn’t melt belly fat. In fact, repeating the same injection site can create lipoatrophy. Terrain first. Pulses before pushes. No spot-reduction fairy tales. Here’s an example of framework to think about it. Start by naming the target: are we rebuilding a tendon muscle unit, or are we re-composing body fat and muscle? If both matter, prioritize the injury pain and function come first. With the target set, run a short terrain tune so the GH axis has a clean runway: smooth glucose, lower CRP drivers, verify thyroid adequacy, anchor sleep, and tame free fatty acids with a simple AM walk. Only then choose the tool. If insulin resistance or high cortisol is on the board, favor physiologic pulses with GHRH/GHRP. If someone is lean, euglycemic, low-inflammation, and under clinical supervision, low-dose GH may be considered. Treat BPC-157 as a cytoprotective adjunct with modest expectations; do not assume in-vivo receptor priming. Place timing to respect biology secretagogues early night or right after rehab, GH scheduled to minimize glycemic drag and rotate injection sites. Then measure, learn, and iterate every one to two weeks using signals you actually trust. Use this little map to set your route before touching the throttle: START -> Choose Goal|- A) Injury/Repair`- B) Body Recomp In practice, the injury/repair path looks like this: clear red flags; run the 14-day terrain tune; choose pulses when insulin or stress is the choke point and reserve clinician-supervised GH for lean, low-inflammation cases; keep BPC-157 as an optional adjunct with clear limits; rebuild tissue on the back of training start with pain-gated isometrics, progress to eccentric-dominant work, then tempo/isotonic and energy-system layering; protect sleep; monitor function, pain, ultrasound if available, HRV/sleep, CGM, and common side-effects like edema or paresthesias; adjust with intent.

My Commitment to You....I want to be transparent: I am learning, testing, and refining every single day. When I find a more effective timing, combination, or mechanism, I’ll share it—even if it means saying, “I was wrong last time.” Integrity > ego. That’s how I hold myself accountable, and it’s the same standard I hold others to. You’re in the right place if you want the most cutting-edge, scientifically accurate information—not hype, not shortcuts. Just the real cellular logic of how we can extend performance, resilience, and healthspan. Parasympathetic Pathway & ERR Biology SLUPP332 doesn’t simply “boost mitochondria.” It works by aligning with the parasympathetic nervous system the body’s rest-and-repair branch. The PNS signals safety, recovery, and digestion. SLUPP332 amplifies that signal, upgrading mitochondrial efficiency so that ATP is produced with less oxidative stress and tighter redox balance. Think of it like a city: as evening falls, the streetlights (parasympathetic tone) turn on. SLUPP332 upgrades the power grid so those lights glow brighter and steadier, without brownouts or wasted energy. In circadian biology, ZT = “Zeitgeber Time,” with ZT0 = lights on and ZT12 = lights off. For humans, ZT10–ZT12 corresponds to the late afternoon—roughly 3–6 pm. This window is critical because: -ERRα and ERRγ expression naturally peak—exactly the receptors SLUPP332 activates. -The body transitions from sympathetic “output mode” into parasympathetic “repair mode.” -Glucose handling declines, while fat oxidation and mitochondrial reliance increase. Administering SLUPP332 here is like handing the night shift a set of new, perfectly tuned tools right as they clock in. The repair crew gets more done, with fewer errors, while the rest of the body rests. To fully unlock SLUPP332’s benefits, it needs co-signals that steer substrate choice and redox balance: -C8–C10 MCT oil (PPARα activators): primes fatty acid oxidation pathways, giving mitochondria the “clean fuel” they prefer under ERR activation.

I've been taking SLU for 6 weeks with no break. Is it advisable to now cycle off for 6 weeks? I've been taking CJC (no DAC)/Ipa for about 4 weeks now, Monday-Friday with a break on the weekend. Will I eventually need to cycle off or can I run this stack indefinitely? I also just started running retatrutide as well...0.5mg 3 times a week with the plan to titrate up to 1mg 3 times a week. What's the timeframe for taking this, and/or does anyone have a good protocol for this?

Over the past few years, I’ve been using GH fairly regularly. I have access to high-quality pharmaceutical-grade GH, so I didn’t overthink it. At my age (54), the difference in how I feel, recover, and sleep is definitely noticeable. That’s always been the main reason I’ve used it, and 2 - 3 IU per day was enough for me. I only increased the dose before a competition to enhance fat burning. However, after listening to and reading content from Antony and Dr. Seeds, I came to understand that constant activation of mTOR and supraphysiological levels of IGF might improve well-being and appearance as we age — but they can also accelerate aging. That said, I used GH mostly while on a ketogenic diet, where GH doesn’t significantly elevate IGF, so that likely minimized the effect. Now I’ve been off GH for two months, and I’d like to test a protocol using GHRH and GHRP, aiming for more pulsatile GH release, and therefore potentially fewer negative effects on long-term health. I have access to the following peptides: Ipamorelin Sermorelin Fragment 176–191 IGF-1 DES MK-677 PEG-MGF MOD-GRF 1-29 CJC-1295 + DAC IGF-1 LR3 What would be the best combinations for: 1. Long-term health 2. Optimal anabolism 3. Fat loss pre-competition Thanks!