Hello all of you brilliant people! My father (71) was diagnosed with prostate cancer last February. He went in for his annual check up with bloodwork. The bloodwork came back witn a PSA level of 7 1/2 to 8. That immediately started the whirlwind of testing for cancer witn biopsies. In the testing they found 6 out of the 12 samples to be cancerous/pre-cancerous. His doctor at that time told him of his treatment options that included radiation and Lupron shots every 3 months for two years 4x a year and removal of the prostate. He didn’t know much about the treatments or side effects but when your Dr. tells you that you have cancer the fear from it will cause you to do anything they say. Thankfully he decided against the removal but agreed to the radiation and shots. The radiation treatments went ok but now he’s on the Lupron shot and having pretty awful side affects. I didn’t know much about the drug but I knew he was suffering and decided to look into it. This is what I found out: Leuprorelin also known as Leuprolide is a manufactured version of a hormone used to treat prostate cancer, endometriosis, uterine fibrosis, for early puberty, transgender hormone therapy, or to perform chemical castration of violent sex offenders. It is given by injection IM. It is a gonadotropin-releasing hormone analogue family of medications. It works by decreasing gonadotropins therefore decreasing natural testosterone and estradiol. Common side effects include high blood sugar, allergic reactions, hot flashes, unstable moods, trouble sleeping, headaches, and water retention/inflammation in joints. He is experiencing all of these and then some! Especially the inflammation in his hands. They look like cartoon hands some days. Fast forward to today. He just got blood results back witn PSA levels that are barely registering. But they are still recommending continuing witn the treatment. My question is why do they want to shut down his testosterone? All of the information that I have read in recently published data shows that testosterone does not cause cancer. And that prostate cancer is a very slow moving cancer that rarely metastasizes unless the patient is in advanced age or metabolically very unhealthy. Is Lupron a necessary treatment for such a condition? And are there any other treatments that are more appropriate for this type of slow moving cancer?

Hey all! I’ve been considering getting some type of wearable to track my health metrics. I see there are so many of them out there. I would like to track mainly my HRV, Sleep, Stress and RHR. Is there anyone who has experience with these and if so were you happy with the results and accuracy of the data? I was thinking of a ring or a band. Thank you!!

🚀 Ketones = Game Changer. This is the thread where I’ll drop my go-to ketone protocols ⚡️ and YOU can fire away with any questions. 💬 Comment your experiences, hacks, and questions below—let’s build the ultimate ketone resource together. 👀 Webinar coming soon… stay tuned. Practical Dosing Blueprints 1.Pre-Workout Protocol (Performance & Focus) Goal: Elevate ketones, buffer acidosis, support hydration & glucose supply. - Hydration: 500–750ml water + electrolytes (sodium 500–1000mg, potassium 200–400mg). - Bicarbonate: 0.3 g/kg sodium bicarbonate (~20g for 70kg athlete), dissolved in water. Take 90–120 min before session to minimize GI upset. - Trehalose (Carbohydrate): 15–25g as slow-release carb for sustained glycogen supply. - Ketone Ester (D-BHB/1,3-BD): 15–25ml (~7–12g KE) 10–15 min pre-warmup. Effect: Dual-fuel system (glucose + BHB), reduced acidosis, enhanced mental focus . 2.Intra-Workout Endurance Protocol Goal: Sustain metabolic efficiency, prevent bonk, extend time-to-exhaustion. - Every 60 min: Trehalose or isomaltulose: 20–30g (slow carb). Ketone Ester: 10–15ml (~5–7g KE). - Optional: electrolyte top-up (sodium/potassium). Effect: Preserves glycogen, stabilizes glucose, sustains BHB 1–3 mM . 3.Post-Workout Recovery Protocol Goal: Accelerate glycogen resynthesis, repair, and inflammation control. - Protein: 20–30g whey or EAAs. - Carbs: 40–60g high-GI glucose or maltodextrin. - Ketone Ester: 20–30ml (~10–15g KE), taken 30–45 min post-exercise (separate from carb/protein drink for maximal signaling). - Trehalose: Add 10–15g if training volume is very high or glycogen depleted. Effect: 50% faster glycogen replenishment, stronger mTOR activation, reduced inflammation . 4.Sleep Recovery Protocol (Athletes) Goal: Deep recovery, improve next-day performance. - Ketone Ester: 2.5–10ml (~1–5g KE) immediately before bed. - Optional: Magnesium glycinate/threonate for additional relaxation.

Any thoughts on Cold Exposure? Specifically cold plunge pre-work out and the science behind it? It’s kind of been all the hype lately in certain circles. I’ve read Wim-Hof’s book about it and although it’s a bit too Woo-Woo for my taste, it did make a lot of sense and did quote studies behind it. So, I thought I’d give it a try. To her displeasure, I Filled the wife’s huge garden tub with cold water and then added several bags of ice. Did some breathing exercises and eased on in. The first 30 seconds were horrifying hell, but after getting my breath back it wasn’t too bad and I started to feel a bit euphoric. It’s hard to describe, but All my thoughts melted away and all I was, was just me in that moment so to speak. If that makes sense. Anyway I managed to stay in for about 4 minutes. I don’t really understand the mechanism behind it. But I got out, air dried for about 15 to 20 minutes and then went to my home gym for a squat session. I must admit, I felt amazing and full of energy! I was just loading that bar and getting under it like a boss! In fact my planned squat only session turned into a full body workout because I wanted to just keep going. I’ve done this 3 more times since with basically the same experience. So here is what I’m wondering. Was my huge amount of energy just because of a big “fight or flight” cortisol spike? Or are there more advanced mechanisms behind this I don’t understand? Do any of you guys do this and if so did you experience the same effect. Or is this something all the smart people are already doing and I’m just late to the party? Thanks in advance to anyone that would like to share their thoughts in this area or their experience with this pre-workout hack.

Here's another group project that I discussed with @Anthony Castore and we agreed having the group work on this together would allow us to receive the best input and put together the best reference list for us all to use. Because the supplement industry is both noisy and inconsistent the distinction between quality/efficacious supplements/compounds and those that are not is often times a very difficult task: some compounds are a commodity-like (creatine monohydrate, bulk amino acids), where purity is relatively easy to achieve and there’s little advantage paying extra for a “designer” label. Other categories — especially lipids (fish oil), fat-soluble antioxidants (CoQ10, carotenoids), or bioactives with low natural stability (PQQ, Urolithin A) — live or die by formulation, raw material source, and quality control. A couple principles that might help as we consider our list: 1. Is it chemically simple or complex? Creatine: single molecule, stable, easy to verify → brand doesn’t matter much if third-party tested. Fish oil, plasmalogens, 1-MNA: unstable lipids or niche molecules → form (TG vs EE vs PC-bound) and oxidation state matter a lot. 2. Does delivery change absorption? Ubiquinol vs Ubiquinone: redox state and carrier lipids improve bioavailability. Liposomal formulations can genuinely help poorly absorbed compounds, but not everything benefits. 3. Is there independent validation? Many of the “designer” claims for things like PQQ, Apigenin, Urolithin A aren’t well-backed by head-to-head human data. In these cases, the real differentiator is whether the company does third-party testing for purity, heavy metals, and stability. 4. Follow the raw material suppliers. Most of the industry is built on the same raw material suppliers (for example, Kaneka for CoQ10, Mitopure for Urolithin A). If a product sources from a top supplier, you’re usually getting the same active regardless of label. The “Amazon brands” like Nutricost or Toniiq can be perfectly fine when they disclose sourcing and batch testing.