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Castore: Built to Adapt

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Where science meets results. Learn peptides, training, recovery & more. No ego, no fluff—just smarter bodies, better minds, built to adapt.

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161 contributions to Castore: Built to Adapt
The Next Generation in Metabolic Optimization: Bioglutide (aIQ-931)
At AlchemIQ Labs, we don’t just follow the science we help write it. While others speculate, we lead with rigorous research, innovative formulations, and uncompromising integrity. Our mission is simple but bold: to redefine what’s possible in cellular medicine and performance by delivering compounds that actually work, not just buzzwords. Every formula we create is grounded in peer-reviewed science. Biogoutide is a first-in-class oral therapy designed to go beyond standard GLP-1 drugs. Where current treatments often sacrifice muscle or cause harsh GI side effects, Bioglutide leverages a quadruple receptor agonist strategy, activating IGF-1, GLP-1, GIP, and glucagon receptors simultaneously. This synergy creates a powerful metabolic reset: GLP-1 + GIP → enhance insulin secretion, improve glucose control, and suppress appetite at the brain level. Glucagon receptor → boosts fat oxidation and raises energy expenditure. IGF-1 receptor → protects and preserves lean muscle mass while fat is being mobilized. Unlike injectables, Bioglutide is orally bioavailable, and is being researched as a once-daily, and able to cross the blood–brain barrier for central appetite modulation. Clinical Proof In Phase 2 clinical trials (13 weeks, 125 participants): Up to 13.8% body weight reduction at the top dose (150 mg/day).No muscle loss observed a key differentiator from GLP-1 monotherapies. Mild side effects only (nausea, diarrhea in <8%), with no severe adverse events. These results position Bioglutide as a superior alternative to single-pathway GLP-1 drugs like semaglutide and tirzepatide, especially for those prioritizing fat loss without compromising muscle integrity. Why It Matters Current GLP-1 agonists are effective but blunt tools—they drive appetite suppression and weight loss but often at the expense of lean tissue and overall metabolic resilience. Bioglutide changes the game by: Targeting multiple pathways at once for balanced, durable results. Preserving muscle through IGF-1 activation while accelerating fat oxidation.
1 like • 3d
@L S That’s a great question. With Bioglutide (just like with tirzepatide or retatrutide), you’re not getting a “formula” that has separate amounts of GLP-1, GIP, glucagon, or IGF-1R added together like ingredients in a supplement blend. Instead, it’s a single, engineered peptide sequence that is designed to interact with multiple receptors at once. Mechanistically, this means: -The peptide binds to and activates specific receptors (GLP-1R, GIPR, GCGR, and indirectly IGF-1R signaling downstream), and the body’s own receptor density and signaling context dictate the magnitude of effect. -It isn’t measured or labeled in terms of “X amount of GLP, Y amount of GIP, Z amount of IGF-1R.” Instead, one dose of the peptide engages all of those receptor systems simultaneously. -Think of it more like a “polyphonic key” that turns on several locks at once, not like mixing four different keys together in measured amounts. -For example, tirzepatide doesn’t contain a measured fraction of GLP-1 vs GIP it is a synthetic unimolecular agonist with dual-binding activity. Bioglutide follows the same logic, except with its own receptor-targeting profile. So when you take a dose, you’re not taking “X mg of IGF-1R” on top of GLP or GIP. You’re taking one compound that, by its structure, influences those receptor pathways in a coordinated way. That’s why you won’t find a label disclosing a separate “amount” of IGF-1R activity because the activity is emergent from the receptor interactions of the whole molecule, not parceled out like ingredients in a multivitamin.
0 likes • 3d
@L S It is a great question and I am sure a lot of other people have been wondering the same thing. Thank you for asking it and I am looking forward to talking on Friday!
I Am Stumped! Calling All Brilliant Minds 🙏
My fiancé has been dealing with some peculiar issues that I’m trying to connect the dots on and would love input. She had lower leg swelling in the past that eventually resolved, and a remote history of Morton’s neuroma that hasn’t been symptomatic for years. Right now her main struggles are poor sleep, consistently low energy, chronic back tightness, and most notably significant thumb pain with joint locking. She describes it as if the thumb “needs to be pulled out.” Both sides were affected at first, but interestingly the untreated side resolved spontaneously while the PRP-treated side continues to be painful and lock regularly. Her job as a personal trainer and working retail means a lot of daily standing, hand and wrist loading, and repetitive strain. Emotionally, she’s carried stress since her father passed away three years ago she handled it well but still has difficult days. Nutritionally, she was vegetarian for about 40 years before introducing chicken 5–6 years ago, but otherwise eats minimal animal protein. My working thought is that this may not just be an isolated tendon or joint problem but a systemic terrain issue possibly a fibrosis-prone environment that explained the paradoxical PRP result, along with lymphatic or vascular fragility from standing all day, circadian and mitochondrial dysfunction contributing to poor energy and recovery, long-term nutrient debt from decades of vegetarianism (creatine, carnitine, B12, zinc, glycine, proline, lysine), and stress physiology from her HPA axis that stiffens fascia and keeps her in sympathetic tone. I’ve sketched out a phased protocol: first reset terrain with circadian support (melatonin or Epitalon), mitochondrial stack (SS-31, Kenetik Pro, plasmalogens), lymphatic strategies (compression, walking, electrolytes), and add Amlexanox as a fibrosis/inflammation reset. Then in phase 2, move to matrix remodeling with BPC-157, TB4, Pentosan Polysulfate, phosphatidylcholine, local tendon glides, red light, topical magnesium, and NeuFit or PEMF for fascia and back tightness, alongside nutrient repletion with collagen peptides, vitamin C, glycine/proline, zinc, copper, and manganese. Finally in phase 3, focus on integration and resilience with Epitalon cycles, MOTS-c, sauna and cold contrast, tendon-friendly strength training, strict sleep hygiene, and nutrient support like creatine, carnitine, and DHA/EPA. I’d re-evaluate with imaging if the thumb pain and locking persist or run labs if swelling recurs. My questions are: does Amlexanox make sense as a first step to rebalance the inflammatory/fibrotic terrain before PPS or repeat PRP? Is the PRP paradox more likely a redox/cellular terrain issue or immune imbalance? And am I over-attributing her back tightness and energy issues to systemic inflammation/lymphatics, or does that reasoning fit? Would love to hear how you all would think through this. @Elizabeth Yurth @Cynthia Keller @Carl Paige @Eric Fete @Eric Serrano anyone else! I’m here to learn and I want to be able to help her.
2 likes • 7d
@Yekaterina Kuznetsova those are great I have her on the NutriDyn brand and plasmalogens as well
0 likes • 5d
@Brady Nielson that would be amazing
Storing Peptides When Buying In Bulk
Question for those of you who buy peptides in bulk. How do you store your lyophilized (not reconstituted) peptides for the long-term? Thanks in advance!
1 like • 6d
The bac water can be left out. It should be fine. That sounds like a good solution. I just keep them a book in the fridge and that has worked well.
0 likes • 5d
@Clay Fitzhugh Hey! Great question. I don’t want to guess, because there are too many confounding variables here. There’s no real standardization across “research peptide” vendors—manufacturing method, salt form/excipients, how long the powder sat before you got it, shipping temps, pH and diluent after reconstitution (bacteriostatic water vs saline), concentration, light/heat exposure, fridge stability, number of punctures, and even the vial/stopper material all change the degradation curve (oxidation, deamidation, adsorption, contamination risk). Without validated stability data from the exact manufacturer and batch, any hard answer on “10 weeks vs 5 weeks” would just be a guess.
Upcoming IG LIVE & Healthspan Conference
Hey guys, per @Anthony Castore kindly inviting me to Post this here, thank you @Anthony Castore Dr William Seeds and I, among many other practitioners will be speaking at the Healthspan Summit in Los Angeles this October, if you want to join , DM me and I can send you a link with my discount code. Also, Elias Arjan, (founder of Healthspan Events and PRUVN) and I will be doing an IG live this Tuesday 9/23/25 at 9am PST. I would love it if you could join us! Here is my IG @leallovio I greatly appreciate this community and your support.
2 likes • 5d
This should be great!
High Dose SLU
This post is more for awareness and curious to hear @Anthony Castore thoughts. It seems like higher dosed SLU is now being promoted. Where the typical dosage is 100mcg-1mg, dosages in the range of 100-400mg are now being promoted. I believe BLL is planning on releasing a 100mg per capsule product. Maybe it is just me, but I can't see this ending well where you are effectively increasing the dosage 100-400 fold. Maybe the price will keep people away (I dont know what the price will be, but gotta imagine it will be very lofty), but there are enough "if some is good more must be better" people out there that I have a feeling someone is going to jump into this without slowly titrating up from much lower dosages to assess tolerance. I don't know if I am being too pessimistic here given my experience of just mixing low dose SLU with BAM sent me into a tailspin, so who knows what 100mg alone or combined with other agents will do. Curious for those folks here, what is the highest dosage SLU you have run (for me its 1.5mg)?
7 likes • 6d
I may feel differently in a few years once human research or real data starts to compile, but right now I can’t justify the leap to 100–400 mg caps. Translating mouse data to humans is never straightforward the models strip away too many confounders we live with daily: polypharmacy, circadian rhythm disruption, diet, epigenetics, individual heterogeneity, and signaling complexity. What looks clean in a controlled rodent study can play out very differently in a human juggling multiple variables at once. We also have to consider the track record here. Jay and BLL have a history of rushing to be first to market, making a big splash, and then having to walk back supplements that didn’t deliver or in some cases, proved harmful. He even admits this in his latest email. To me, that makes it even more critical to be cautious when talking about doses that represent a 100- to 400-fold increase over what most of us have actually tested in real people. Mechanistically, overstimulating ERR carries serious potential downsides. It’s not just about metabolic push; ERR is tightly tied to angiogenesis and mitochondrial uncoupling. Push too hard, and you risk off-target activation, destabilized redox balance, and downstream signaling chaos. This isn’t a benign “more fuel = more performance” equation it’s a gamble with pathways that can cut both ways. For context, I’ve done well at 400 mcg. That doesn’t mean higher doses are impossible, it just means that for me and for the markers I track (RER improvements, sleep quality, concentration, recovery between sessions) that’s where the benefit is both visible and repeatable. I have clients who do well at as little as 100 µg, and others who tolerate 3–4 mg. The point is: we’re seeing real measurable changes at these levels. It’s hard for me to justify blowing past that window simply because the promotion has shifted toward massive dosing. I am always learning, and I keep an open mind. But gambling with health on something that hasn’t even been studied in documented human trials isn’t a move I can recommend. Precision matters more than bravado here. Just because higher caps are being marketed doesn’t mean biology is ready to cooperate.
1 like • 5d
@Drew Wurst well said! I completely agree.
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Anthony Castore
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Anthony Castore — SSRP Fellow & strength coach blending peptides, training, and cellular medicine to optimize performance and recovery.

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Joined Jul 31, 2025
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