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19 contributions to Castore: Built to Adapt
Storing Peptides When Buying In Bulk
Question for those of you who buy peptides in bulk. How do you store your lyophilized (not reconstituted) peptides for the long-term? Thanks in advance!
0 likes ‱ 5d
@Anthony Castore I've been ordering 10mg vials of ipamorelin and that vial lasts 10 weeks. Is that too long to be kept in the fridge? Do I need to scale back and start ordering 5mg vials?
2 likes ‱ 5d
@Anthony Castore so the best we can do, from what it sounds like, is an educated guesstimate! 😂😂😂 But from what you have told me, it sounds like when in doubt, purchase vials that, when reconstituted, will be used in shorter period of time versus a longer period of time...i.e. a vial that will be consumed in 5 weeks as opposed to 10 weeks.
I Am Stumped! Calling All Brilliant Minds 🙏
My fiancĂ© has been dealing with some peculiar issues that I’m trying to connect the dots on and would love input. She had lower leg swelling in the past that eventually resolved, and a remote history of Morton’s neuroma that hasn’t been symptomatic for years. Right now her main struggles are poor sleep, consistently low energy, chronic back tightness, and most notably significant thumb pain with joint locking. She describes it as if the thumb “needs to be pulled out.” Both sides were affected at first, but interestingly the untreated side resolved spontaneously while the PRP-treated side continues to be painful and lock regularly. Her job as a personal trainer and working retail means a lot of daily standing, hand and wrist loading, and repetitive strain. Emotionally, she’s carried stress since her father passed away three years ago she handled it well but still has difficult days. Nutritionally, she was vegetarian for about 40 years before introducing chicken 5–6 years ago, but otherwise eats minimal animal protein. My working thought is that this may not just be an isolated tendon or joint problem but a systemic terrain issue possibly a fibrosis-prone environment that explained the paradoxical PRP result, along with lymphatic or vascular fragility from standing all day, circadian and mitochondrial dysfunction contributing to poor energy and recovery, long-term nutrient debt from decades of vegetarianism (creatine, carnitine, B12, zinc, glycine, proline, lysine), and stress physiology from her HPA axis that stiffens fascia and keeps her in sympathetic tone. I’ve sketched out a phased protocol: first reset terrain with circadian support (melatonin or Epitalon), mitochondrial stack (SS-31, Kenetik Pro, plasmalogens), lymphatic strategies (compression, walking, electrolytes), and add Amlexanox as a fibrosis/inflammation reset. Then in phase 2, move to matrix remodeling with BPC-157, TB4, Pentosan Polysulfate, phosphatidylcholine, local tendon glides, red light, topical magnesium, and NeuFit or PEMF for fascia and back tightness, alongside nutrient repletion with collagen peptides, vitamin C, glycine/proline, zinc, copper, and manganese. Finally in phase 3, focus on integration and resilience with Epitalon cycles, MOTS-c, sauna and cold contrast, tendon-friendly strength training, strict sleep hygiene, and nutrient support like creatine, carnitine, and DHA/EPA. I’d re-evaluate with imaging if the thumb pain and locking persist or run labs if swelling recurs. My questions are: does Amlexanox make sense as a first step to rebalance the inflammatory/fibrotic terrain before PPS or repeat PRP? Is the PRP paradox more likely a redox/cellular terrain issue or immune imbalance? And am I over-attributing her back tightness and energy issues to systemic inflammation/lymphatics, or does that reasoning fit? Would love to hear how you all would think through this. @Elizabeth Yurth @Cynthia Keller @Carl Paige @Eric Fete @Eric Serrano anyone else! I’m here to learn and I want to be able to help her.
3 likes ‱ 8d
@Drew Wurst I'm thinking along the same line as you. Could it be as simple as an allergic reaction of some sort? Probably not. But it's also not outside the realm of possibility. I'd say it's definitely worth checking out for sure.
Lumen
Just curious if anyone has used the Lumen metabolic device. If so, I would love to hear any any feedback anyone has to offer!
1 like ‱ 14d
@Drew Wurst so I just took my first reading this morning and I got a reading of 4...
1 like ‱ 14d
@Drew Wurst interesting enough, I'm following the protocol to find my ideal "fasted window" and I will say that my first reading at 5:50 was a 4, and my 2nd reading at 7:28 was a 3...
The downsides of synthetic GH and transition to Peptides
Over the past few years, I’ve been using GH fairly regularly. I have access to high-quality pharmaceutical-grade GH, so I didn’t overthink it. At my age (54), the difference in how I feel, recover, and sleep is definitely noticeable. That’s always been the main reason I’ve used it, and 2 - 3 IU per day was enough for me. I only increased the dose before a competition to enhance fat burning. However, after listening to and reading content from Antony and Dr. Seeds, I came to understand that constant activation of mTOR and supraphysiological levels of IGF might improve well-being and appearance as we age — but they can also accelerate aging. That said, I used GH mostly while on a ketogenic diet, where GH doesn’t significantly elevate IGF, so that likely minimized the effect. Now I’ve been off GH for two months, and I’d like to test a protocol using GHRH and GHRP, aiming for more pulsatile GH release, and therefore potentially fewer negative effects on long-term health. I have access to the following peptides: Ipamorelin Sermorelin Fragment 176–191 IGF-1 DES MK-677 PEG-MGF MOD-GRF 1-29 CJC-1295 + DAC IGF-1 LR3 What would be the best combinations for: 1. Long-term health 2. Optimal anabolism 3. Fat loss pre-competition Thanks!
0 likes ‱ 26d
@Gasper Grom to parrot what @L S said, I'dbe interested as well. Again, if you're willing to share.
đŸ”„ Big news, friends—our community is about to level up in a massive way
📌 First up
 the votes are in for our SLU-PP-332 Webinar!🗓 Saturday, August 23rd at 10 AM ESTThis isn’t just another presentation—this is the deep dive. In one session, you’ll go from curious to industry fluent. We’ll bust the myths, show you exactly what SLU-PP-332 is, how it works, when to use it (and when not to), and walk through every pathway and mechanism that matters. No stone will be left unturned, and you’ll leave with the clarity and confidence to make informed decisions that maximize health outcomes. 📌 Next up
 Case Breakdown LIVE🗓 Monday, August 25th at 5 PM ESTI’m pulling back the curtain on my own protocol—explaining my entire thought process, the “why” behind each step, and how to approach your own situations with system-based thinking. This will become a monthly tradition where members can submit their own cases for us to work through as a group. The goal? Tap into the brainpower of this community and learn from each other’s unique perspectives. 🌟 Member of the Month is launching!Every month, I’ll randomly choose one of you for a short interview and spotlight. This is about celebrating you—your story, your journey, and how we can better support one another. Got someone you’d love to see featured? Send me your suggestions (just not yourself 😉). đŸ’„ This community stays FREEI love the energy, curiosity, and generosity here. All I ask—help me hit 1,000 members. The more like-minded people we have, the faster we all grow. Invite your friends, colleagues, and anyone who loves this work. 🛒 Buyers Club is here My first pick: Kinetik Pro. Every two weeks, I’ll coordinate a group order. Depending on participation, we’ll score 10–25% off. I will put a seperate post up on this soon but ofr now you can message me direct. When we have a system dialed in I will add these other lines including access to: BodyBio, Metagenics, Thorne, NutraDyn, Orthomolecular, 1-MNA, NuBioAge, Prodrome, Healthgevity and more to come! đŸŽ„ Recordings & ResourcesAll webinars, Q&As, and courses will be available for $39.99 each, OR
 grab a $200/year subscription and get everything—plus a monthly ebook packed with deep-dive, actionable protocols. That’s over $760 in savings while directly supporting the growth of this community.
4 likes ‱ Aug 15
@Anthony Castore where will the links for the Saturday webinar and Monday case study be posted?
2 likes ‱ Aug 24
@Anthony Castore did the coach's protocol call get moved? In this post in says the 25th but the calendar invite says the 26th. Would you mind clarifying if the call is tomorrow or Tuesday? Thanks!
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Clay Fitzhugh
4
85points to level up
@clay-fitzhugh-7466
Here to learn and grow in my fitness journey

Active 5m ago
Joined Aug 1, 2025
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