I hope everyone had a fantastic weekend! We’ve got some exciting updates this week, and I wanted to bring everything together in one post for simplicity. First, big news the Kenetik Pro Buyers Club is officially launching! If you’ve been curious about trying the supplement I personally rely on the most, ketone esters, now’s your chance. I’m thrilled to be able to offer both access and savings. I’ve put together a thread that breaks down everything you’ll need—how to order, how many bottles you’ll likely go through in a month, and pricing details. Next, a quick clarification on the upcoming free webinar. This one is going to pull back the curtain on my own protocol and thought process. You’ll get the full, no-holds-barred breakdown of what I take, why I take it, and how I pair it with training, nutrition, and lifestyle strategies. My goal is to help you see things through a systemic lens so you can craft protocols that are more precise and effective. I want this to be fun, transparent, and useful and I’ll say up front, I’m learning every day right alongside you. Feedback (positive or critical) is always welcome. My plan is to make this a monthly feature, including not just my own protocols but also other people’s, so we can grow as a community of protocol designers together. Finally, a huge thank-you to Kassem Hanson of N1. He’s been an incredible resource for me personally and for our community. I’m currently enrolled in his program design mentorship, and if you want to learn the N1 approach, I can’t recommend their online and in-person seminars enough. They teach customization and critical thinking in a way that resonates whether you’re brand-new or decades into this field. Kassem generously edited the SLU webinar from Saturday, and I’ll be posting the recording soon for anyone who couldn’t attend. I’ll also be sharing the slides here, so if you haven’t received them by email, keep an eye out for the link. Link to webinar reply Thank you all so much for your support and for the energy you bring to this community. Everything we’re building here is possible because of each of you. Please don’t hesitate to reach out if there’s something you’d like to see more of, or if you have suggestions on how I can serve you better. I’m here for you guys!

Hi @Anthony Castore I wanted to know your thoughts on taking slu-pp after taking cardarine. I took cardarine pre gym about 1:00pm. How long should I wait u til I take the slu? Or should not mix the two ? Also I wanted to incorporate Bam15 in the mix. I know you mentioned take on your rest days, but my rest days are only 2 days per week when I’m doing cardio. Will I benefit from this or can I incorporate into my resistance training. Routine. ?

This post is more for awareness and curious to hear @Anthony Castore thoughts. It seems like higher dosed SLU is now being promoted. Where the typical dosage is 100mcg-1mg, dosages in the range of 100-400mg are now being promoted. I believe BLL is planning on releasing a 100mg per capsule product. Maybe it is just me, but I can't see this ending well where you are effectively increasing the dosage 100-400 fold. Maybe the price will keep people away (I dont know what the price will be, but gotta imagine it will be very lofty), but there are enough "if some is good more must be better" people out there that I have a feeling someone is going to jump into this without slowly titrating up from much lower dosages to assess tolerance. I don't know if I am being too pessimistic here given my experience of just mixing low dose SLU with BAM sent me into a tailspin, so who knows what 100mg alone or combined with other agents will do. Curious for those folks here, what is the highest dosage SLU you have run (for me its 1.5mg)?

My fiancé has been dealing with some peculiar issues that I’m trying to connect the dots on and would love input. She had lower leg swelling in the past that eventually resolved, and a remote history of Morton’s neuroma that hasn’t been symptomatic for years. Right now her main struggles are poor sleep, consistently low energy, chronic back tightness, and most notably significant thumb pain with joint locking. She describes it as if the thumb “needs to be pulled out.” Both sides were affected at first, but interestingly the untreated side resolved spontaneously while the PRP-treated side continues to be painful and lock regularly. Her job as a personal trainer and working retail means a lot of daily standing, hand and wrist loading, and repetitive strain. Emotionally, she’s carried stress since her father passed away three years ago she handled it well but still has difficult days. Nutritionally, she was vegetarian for about 40 years before introducing chicken 5–6 years ago, but otherwise eats minimal animal protein. My working thought is that this may not just be an isolated tendon or joint problem but a systemic terrain issue possibly a fibrosis-prone environment that explained the paradoxical PRP result, along with lymphatic or vascular fragility from standing all day, circadian and mitochondrial dysfunction contributing to poor energy and recovery, long-term nutrient debt from decades of vegetarianism (creatine, carnitine, B12, zinc, glycine, proline, lysine), and stress physiology from her HPA axis that stiffens fascia and keeps her in sympathetic tone. I’ve sketched out a phased protocol: first reset terrain with circadian support (melatonin or Epitalon), mitochondrial stack (SS-31, Kenetik Pro, plasmalogens), lymphatic strategies (compression, walking, electrolytes), and add Amlexanox as a fibrosis/inflammation reset. Then in phase 2, move to matrix remodeling with BPC-157, TB4, Pentosan Polysulfate, phosphatidylcholine, local tendon glides, red light, topical magnesium, and NeuFit or PEMF for fascia and back tightness, alongside nutrient repletion with collagen peptides, vitamin C, glycine/proline, zinc, copper, and manganese. Finally in phase 3, focus on integration and resilience with Epitalon cycles, MOTS-c, sauna and cold contrast, tendon-friendly strength training, strict sleep hygiene, and nutrient support like creatine, carnitine, and DHA/EPA. I’d re-evaluate with imaging if the thumb pain and locking persist or run labs if swelling recurs. My questions are: does Amlexanox make sense as a first step to rebalance the inflammatory/fibrotic terrain before PPS or repeat PRP? Is the PRP paradox more likely a redox/cellular terrain issue or immune imbalance? And am I over-attributing her back tightness and energy issues to systemic inflammation/lymphatics, or does that reasoning fit? Would love to hear how you all would think through this. @Elizabeth Yurth @Cynthia Keller @Carl Paige @Eric Fete @Eric Serrano anyone else! I’m here to learn and I want to be able to help her.

I got a few vials of MOTS-c and SS-31, and if I understand correctly, this seems like an interesting complementary combination for improving mitochondrial function. MOTS-c activates AMPK, while SS-31 targets cardiolipin and works as an antioxidant. Here’s what I was thinking: MOTS-c: subcutaneous, 5 mg, 2x per week, for 4 weeks SS-31: subcutaneous, 2 mg daily, 3x per week, mainly on rest days Does this protocol make sense, and what kind of supplements could I add alongside to maximize the benefits of the cycle?