I thought this might be right up your alley to discuss @Anthony Castore . I am seeing the topic pick up again about why you should avoid BPC/TB due to possible increase in cancer likelihood. I can't tell if this is all just fear mongering or not. There doesn't appear to be any evidence regarding this outside of referencing a mouse study that was done: ---------------------------------------------------------------------------------------------------------------------------------------------------------- "In most solid tumors studied in mice, including fibrosarcoma, melanoma, non-small cell lung cancer (NSCLC), colon cancer, and glioblastoma, TB4 overexpression promotes tumor growth, metastasis, and angiogenesis." ----------------------------------------------------------------------------------------------------------------------------------------------------------- One person is stating that since BPC up-regulates VEGF, this would be a pathway towards cancer development (below is what they posted). ----------------------------------------------------------------------------------------------------------------------------------------------- VEGF is historically a promoting factor in oncological aspects rather than causative, but this isn't the only concern. VEGF was originally named "vascular permeability factor" for a reason. It opens gaps between endothelial cells, letting plasma proteins and fluid leak into the interstitial space. Off-target stimulation means edema in tissues that don't need increased perfusion. The problem is that VEGF receptors sit on endothelial cells throughout the entire body, not just in the tissue you're trying to help. So if VEGF reaches non-target tissues, several things go wrong. It can produce off-target angiogenesis, meaning new blood vessel growth where you do not want it. That can produce abnormal, fragile, leaky vessels rather than healthy functional ones. VEGF also increases vascular permeability, so tissue can become swollen or edematous. PMID: 35969170, 20400620

Has anyone experienced this side effect? Nerve sensitivity or burning in the legs from Reta? It’s kind of like a sunburn, sensitive to the touch?

This community exists to correct a problem I see every day: smart, motivated people making avoidable mistakes because they are reacting to information instead of reasoning through it. Everything here is built around clear thinking, proper sequencing, and confident restraint. There are several ways to engage. Each one is designed for a different level of responsibility. The question is not whether to invest. The question is where you are right now. The Cellular Intelligence Circle For Orientation, Context, and Staying Current The Circle is where confusion gets resolved before it turns into action. This is the right place if you want to: - Understand emerging science without overreacting to it - Learn how decisions are actually weighed - Separate signal from noise - Avoid unnecessary intervention It is a content-first environment designed to compound over time. Membership provides access to a growing, curated body of work that functions as a reference library, not a feed to keep up with. Inside the Circle: - Peptide of the Month (mechanism, context, restraint) - Protocol and case reasoning breakdowns - Science article reviews focused on interpretation, not hype - Monthly live Q and A - Periodic synthesis webinars The Circle is not coaching. It is not protocol delivery. It is where judgment is built. Pricing - $79 per month - $219 for three months - $499 for twelve months This level is appropriate when your primary goal is orientation, understanding, and staying sharp. One-Time Consultations For Specific Decisions. Consultations exist for moments when a decision needs to be handled correctly. They focus on: - Identifying what actually matters - Removing unnecessary complexity - Clarifying what not to do Pricing - One hour consultation: $350 - One hour consultation with follow-up: $500 This option makes sense when a single decision needs careful thought. Ongoing Advisory Core For Continuity and Guardrails. This is for people who no longer want to think through complex decisions in isolation.

Anyone on or thinking about PPS please look at this. I’m certainly glad i went with my gut instincts and avoided this medication for my knee osteoarthritis. Wow! pretty scary indeed! https://pubmed.ncbi.nlm.nih.gov/41379439/

Ahoy everyone! Just thinking through something. I'm in month two of my first cycle of Terzepitide. Nice even body fat reduction, lower dosing as I am a hyper responder, minimum sides. Will be riding this out for a few more months. I wanted to get some opinions...maybe @Anthony Castore can chime in. I have one bottle of SLU in house. 30 capsules of 100mcg per capsule. How might I use this bottle of SLU to enhance the effects of this Terz cycle? I am wont to stay away from stacking because I don't want to over signal. What are the options here? Wait till I am done with Terz and just run that bottle of SLU? Wait till I am done with Terz and get more SLU and run a greater amount over a longer period of time? Throw the SLU in during my taper-off from Terz...so, a little bit of stacking? Or... Risk wasting the money I spent on the SLU and just throw it in to the middle of the Terz cycle and see what happens...for the sake of science? : ) Thoughts?