This is the kind of study I get excited about, because it's not theoretical. It's real numbers. β 96 women with PMOS and a BMI over 25 went through six months of semaglutide treatment. Before treatment, 83% had irregular or absent ovulation. After six months... average weight dropped about 11%, and ovulatory cycles returned in over half of previously anovulatory women. In the overweight (not obese) group specifically, almost 95% saw their cycles normalize. β I want to be precise about what this does and doesn't say. This isn't "GLP-1s cure PMOS." It's evidence that for a specific group, treating the metabolic piece first (weight, insulin resistance) can be what unlocks the cycle piece, before jumping straight to fertility-specific treatments. The authors' own conclusion: consider GLP-1 agonists before treatments aimed only at inducing ovulation, for the right patients. β This is exactly the "sequence matters" conversation I have all the time. Not every path to regular cycles runs through a fertility drug first. Sometimes it runs through the metabolic piece. β π The study: https://pubmed.ncbi.nlm.nih.gov/42452625/ β Has anyone here had a provider talk to you about GLP-1s as part of your PMOS care... not just for weight, but for cycles? I'd love to know how that conversation went.