What protocol do you follow to minimize jet lag, avoid drops in HRV, and improve sleep after traveling to a different time zone? @Anthony Castore

I was watching a pod cast where the podcaster was talking about mega dosing this a couple times a year to get rid of senecese cells. Does anyone have experience with this or know if it is a real functional option. I just read an old article by Anthony o er on Chris Duffins endless evolution about layering Foxo4 Dri amd other peptides. Really enjoyed the article

I've got some of this on hand and am planning to run it. I've seen online, and from friends, who use igf-1lr3 that they're pinning right before work out into the targeted muscle. During workout they'll experience huge pumps. However, I heard Anthony on one of the DDT Method podcasts saying to run peg-mgf immediately post work out and igf-1lr3 the next day. Can anyone help with the reasoning to run this one way over the other the other?

When you train hard but feel like your body isn’t responding like it used to, it’s not just aging or bad luck. Deep inside your muscles, a type of cellular clutter starts to build up these are called senescent cells, often nicknamed zombie cells. They’re old, damaged cells that have stopped dividing but refuse to die. Instead, they hang around releasing inflammatory signals that disrupt everything around them. Over time, they block the very pathways that your training is supposed to activate. It’s like trying to grow a garden in soil full of toxins. Every cell in your body has a life cycle. Healthy cells divide, do their job, and when they become too damaged, they self-destruct through a process called apoptosis. Senescent cells are the exception. They survive by overriding that self-destruct button. These cells secrete inflammatory molecules, growth factors, and enzymes that damage neighboring cells a collection of signals known as the SASP, or senescence-associated secretory phenotype. In small doses, SASP can help heal wounds. But when it lingers, it becomes a chronic source of inflammation that weakens tissues. In muscle, SASP molecules like IL-6, IL-8, TNF-alpha, and TGF-beta disrupt how muscle stem cells, called satellite cells, communicate. These satellite cells are the key players in muscle repair and growth. When their environment is polluted by SASP, they stop responding to the normal anabolic cues from training, and muscle growth stalls. Senescent cells also drag down mitochondrial function. Mitochondria are your cells’ power plants, generating energy through respiration. In senescent cells, mitochondria become damaged and inefficient, leaking electrons that generate excessive reactive oxygen species, or ROS. This oxidative stress overwhelms the body’s antioxidant defenses and shifts the cell from a growth mode to a survival mode. Pathways like mTOR and IGF-1 that normally promote protein synthesis are suppressed, while stress pathways like NF-κB and p53 become chronically activated. The result is a body that’s inflamed, tired, and resistant to adaptation no matter how hard you train.

I hope everyone had a fantastic weekend! We’ve got some exciting updates this week, and I wanted to bring everything together in one post for simplicity. First, big news the Kenetik Pro Buyers Club is officially launching! If you’ve been curious about trying the supplement I personally rely on the most, ketone esters, now’s your chance. I’m thrilled to be able to offer both access and savings. I’ve put together a thread that breaks down everything you’ll need—how to order, how many bottles you’ll likely go through in a month, and pricing details. Next, a quick clarification on the upcoming free webinar. This one is going to pull back the curtain on my own protocol and thought process. You’ll get the full, no-holds-barred breakdown of what I take, why I take it, and how I pair it with training, nutrition, and lifestyle strategies. My goal is to help you see things through a systemic lens so you can craft protocols that are more precise and effective. I want this to be fun, transparent, and useful and I’ll say up front, I’m learning every day right alongside you. Feedback (positive or critical) is always welcome. My plan is to make this a monthly feature, including not just my own protocols but also other people’s, so we can grow as a community of protocol designers together. Finally, a huge thank-you to Kassem Hanson of N1. He’s been an incredible resource for me personally and for our community. I’m currently enrolled in his program design mentorship, and if you want to learn the N1 approach, I can’t recommend their online and in-person seminars enough. They teach customization and critical thinking in a way that resonates whether you’re brand-new or decades into this field. Kassem generously edited the SLU webinar from Saturday, and I’ll be posting the recording soon for anyone who couldn’t attend. I’ll also be sharing the slides here, so if you haven’t received them by email, keep an eye out for the link. Link to webinar reply Thank you all so much for your support and for the energy you bring to this community. Everything we’re building here is possible because of each of you. Please don’t hesitate to reach out if there’s something you’d like to see more of, or if you have suggestions on how I can serve you better. I’m here for you guys!