@Anthony Castore : Can't make the live the Q&A tomorrow about: "Peptides, mitochondria, training, recovery, redox, nutrition nothing off limits" Can you share some yearly Mitochondrial protocols. How many times a year should we do a mitochondrial stack? Best frequency, order, dosing and timing of mitochondria stacks. My current stack "in order of use", 1X per year: FOXO4-DRI - Dose: 1 mg every other day- Duration: 3 doses over ~5 days- Goal: Senescent cell clearance before mitochondrial repair phase. SS-31 - Dose: 10 mg daily- Duration: 10–14 days- Timing: Used on high-energy days- Goal: Mitochondrial biogenesis and membrane stabilization. MOTS-c - Starting Dose: 1 mg (titrate up to 2.5–5 mg as tolerated)- Frequency: 3x per week on workout days (AM only)- Duration: 4–6 weeks- Goal: Boost mitochondrial function, glucose metabolism, exercise performance. HUMANIN - Dose: 1 mg daily- Duration: 30 days- Timing: Begin a few days after MOTS-c to compare effects- Goal: Mimic fasting, support cognitive function, and mitochondrial protection. Looking forward to your input, changes, additions or reorder.

Hey guys, per @Anthony Castore kindly inviting me to Post this here, thank you @Anthony Castore Dr William Seeds and I, among many other practitioners will be speaking at the Healthspan Summit in Los Angeles this October, if you want to join , DM me and I can send you a link with my discount code. Also, Elias Arjan, (founder of Healthspan Events and PRUVN) and I will be doing an IG live this Tuesday 9/23/25 at 9am PST. I would love it if you could join us! Here is my IG @leallovio I greatly appreciate this community and your support.

🚀 Ketones = Game Changer. This is the thread where I’ll drop my go-to ketone protocols ⚡️ and YOU can fire away with any questions. 💬 Comment your experiences, hacks, and questions below—let’s build the ultimate ketone resource together. 👀 Webinar coming soon… stay tuned. Practical Dosing Blueprints 1.Pre-Workout Protocol (Performance & Focus) Goal: Elevate ketones, buffer acidosis, support hydration & glucose supply. - Hydration: 500–750ml water + electrolytes (sodium 500–1000mg, potassium 200–400mg). - Bicarbonate: 0.3 g/kg sodium bicarbonate (~20g for 70kg athlete), dissolved in water. Take 90–120 min before session to minimize GI upset. - Trehalose (Carbohydrate): 15–25g as slow-release carb for sustained glycogen supply. - Ketone Ester (D-BHB/1,3-BD): 15–25ml (~7–12g KE) 10–15 min pre-warmup. Effect: Dual-fuel system (glucose + BHB), reduced acidosis, enhanced mental focus . 2.Intra-Workout Endurance Protocol Goal: Sustain metabolic efficiency, prevent bonk, extend time-to-exhaustion. - Every 60 min: Trehalose or isomaltulose: 20–30g (slow carb). Ketone Ester: 10–15ml (~5–7g KE). - Optional: electrolyte top-up (sodium/potassium). Effect: Preserves glycogen, stabilizes glucose, sustains BHB 1–3 mM . 3.Post-Workout Recovery Protocol Goal: Accelerate glycogen resynthesis, repair, and inflammation control. - Protein: 20–30g whey or EAAs. - Carbs: 40–60g high-GI glucose or maltodextrin. - Ketone Ester: 20–30ml (~10–15g KE), taken 30–45 min post-exercise (separate from carb/protein drink for maximal signaling). - Trehalose: Add 10–15g if training volume is very high or glycogen depleted. Effect: 50% faster glycogen replenishment, stronger mTOR activation, reduced inflammation . 4.Sleep Recovery Protocol (Athletes) Goal: Deep recovery, improve next-day performance. - Ketone Ester: 2.5–10ml (~1–5g KE) immediately before bed. - Optional: Magnesium glycinate/threonate for additional relaxation.

One of the best parts of this journey is having mentors who push me to keep learning and questioning. @Elizabeth Yurth has been that kind of mentor for me. She’s not only a brilliant mind in cellular medicine, she’s also someone who constantly reminds me to dig deeper, challenge assumptions, and ask better questions. It was actually Dr. Yurth who got me to revisit the research around Fatty15. Her guidance along with the incredible work she’s doing through the Boulder Longevity Institute and her Human Optimization Academy has been a game-changer for me and so many others. Having people like her in my corner makes me a better student, a better teacher, and hopefully of better service to all of you. With that in mind, I wanted to share some thoughts on Fatty15, the hype, the skepticism, and what we can really learn from it when we zoom out and ask deeper questions. Fatty 15 has become one of the most talked-about molecules in the wellness and longevity space, not because it is new to science, but because of the way it has been packaged and sold. Marketed as the first “essential” odd-chain saturated fatty acid, Fatty 15 (the supplement form of C15:0) promises to stabilize membranes, reduce inflammation, and extend healthspan. For many, the narrative is seductive: here is a nutrient that has been hiding in plain sight, maligned by decades of anti-saturated-fat dogma, finally rebranded as a cornerstone of cellular resilience. But step back from the marketing and look at the science, and the picture becomes more complex. Lipidologists and metabolic researchers, including Dr. Dayan Goodenowe, argue that high levels of pentadecanoic acid in the blood are not causal but correlative. In other words, elevated C15:0 is a marker of robust lipid metabolism, not the reason for it. To use an analogy, it’s like noticing that healthy cities all have clean street signs and then deciding that shipping in more street signs will fix a crumbling city. The signs are a marker of order; they are not the thing that creates it. Supplementing with C15:0 without repairing upstream dysfunction may not move the needle and in some cases, may even make things worse.

I’m excited to announce the launch of our Kenetik Pro Buyers Club your inside track to getting the cleanest, highest-performing ketone fuel delivered right to you. Here’s how it works: ✅ Message me your order by Wednesday each week ✅ I place our group order every Thursday ✅ Product ships to me (about a 5-day turnaround) ✅ Once it arrives, I immediately re-ship your order to you via UPS This system ensures faster turnaround, better consistency, and smooth logistics for everyone. Kenetik Pro has been a game-changer for performance, recovery, and metabolic flexibility and now, through the Buyers Club, you’ll have a reliable way to keep it stocked without the usual delays. ⚡️ Action Step: If you want in this week, send me your order by Wednesday night and you’ll be included in Thursday’s batch. Let’s keep leveling up together. 🔥 Flavors: Strawberry-Peach Blackberry-Lemonade Pineapple-Passionfruit KenetikPro Ketone Concentrate 3-Pack (3 Bottles) 3-Pack MSRP: $130.00 KenetikPro Case - 24 Bottles (8 Packs of 3 Bottles Each) $994.00 USD Case Quantity | Case Price | Case Discount 1-2 $994.00 3-9 $874.80 10+ $755.60 ================================================== Maintain 20 0.25 bottles/day 8 bottles/month Prevention, Focus, Energy ================================================== Repair 40 0.5 bottles/day 15 bottles/month Cognitive Decline, Memory Impairment, Brain Fog, APOE4 Genetic Risk Factor, Metabolic Control ================================================== Therapeutic 80 1 bottle/day 30 bottles/month Neurodegenerative Diseases & Injuries, such as Alzheimer’s, Parkinson's, MS, ALS, TBI, CTE ===================================================