Supplements & Natural Agents for GLP-1 Support - Pt - 4 of 8

Rheece Hartte

Aug 24 • Give Advice

Supplements and foods work naturally & don’t act like exactly semaglutide or tirzepatide, however they can still -

stimulate natural GLP-1 secretion,
improve receptor sensitivity,
slow carbohydrate absorption (which indirectly raises GLP-1 signaling)

Overall Ranking (Most to Least Effective for GLP-1)

These do have DIFFERENT Health Benefits for Fat Loss, Blood Sugar Control & Metabolism OTHER than just affecting GLP-1.

So they are in order of GLP-1 activity specifically -

Resistant Starches (foods: green bananas, cooked & cooled potatoes/rice, legumes, oats). More on this in future posts.

Mechanism: Fermented by gut bacteria → produces SCFAs (butyrate, propionate) → stimulates GLP-1 release.
Effectiveness: Strong human evidence; one of the best natural ways to raise GLP-1.

2.Akkermansia muciniphila (Akkermansia-specific probiotics or prebiotics that feed it) - More on this in future posts.

Mechanism: This gut microbe strengthens the gut barrier and produces metabolites that enhance GLP-1 and improve insulin sensitivity.
Effectiveness: Human clinical data emerging — promising for obesity, diabetes, metabolic health.

3.Berberine

Mechanism: Activates AMPK, improves insulin sensitivity, slows carb absorption, and may increase GLP-1 secretion.
Effectiveness: Comparable in some studies to metformin; strong indirect GLP-1 support.

4.Yerba Mate

Mechanism: Polyphenols stimulate GLP-1 secretion, improve satiety, and slow gastric emptying.
Effectiveness: Good human evidence for appetite control and GLP-1 rise.

5.Cinnamon

Mechanism: Improves insulin sensitivity, slows gastric emptying, modestly enhances GLP-1 release.
Effectiveness: Moderate; useful adjunct for blood sugar and appetite.

6. Apple Cider Vinegar

Mechanism: Slows gastric emptying, blunts post-meal glucose spikes → indirectly boosts GLP-1.

7. Turmeric (Curcumin)

Mechanism: Anti-inflammatory; may modulate gut microbiota and L-cell signaling to promote GLP-1.

8.Bitter Melon

Mechanism: Mimics insulin, enhances GLP-1 secretion, improves beta-cell function.

9.Chromium

Mechanism: Enhances insulin sensitivity; some data suggests higher GLP-1 secretion.

10.Bergamot (Citrus polyphenols)

Mechanism: Improves lipid metabolism, endothelial health, and gut hormone balance including GLP-1.

Lemon Balm (Melissa officinalis)

Mechanism: Calming herb; may influence GABA and gut-brain signaling → mild effect on GLP-1.

Green Tea (EGCG)

Mechanism: Catechins improve insulin sensitivity, modulate gut microbiota, may stimulate GLP-1.

Resveratrol

Mechanism: Activates SIRT1, improves mitochondrial and metabolic signaling, possible GLP-1 enhancement.

Saffron

Mechanism: Appetite regulation (serotonin and dopamine), not GLP-1 specific.

5-HTP

Mechanism: Increases serotonin → appetite control; may indirectly affect GLP-1 release.

Taurine

Mechanism: Improves bile acid metabolism, insulin sensitivity; weak links to GLP-1 modulation.

N-Acetylcysteine (NAC)

Mechanism: Glutathione precursor; antioxidant reducing inflammation. No strong GLP-1 link.

Bluperdium (likely Bupleurum / herbal extract)

Mechanism: Traditional Chinese herb for liver/gut health; minimal direct evidence on GLP-1.

FitnHealthy Forever Tip -

The strongest natural GLP-1 boosters come from diet (resistant starch), targeted probiotics (Akkermansia - more on this to come), and metabolic botanicals (berberine, yerba mate).

In Part 5 & Part 6 we'll explore the 2 Top GLP-1 Natural Boosters and Food Support.

Interested in Saving Time & Money without the dangerous potential Symptoms of Drugs? ✅

Just give me the short term "shot" - I don't care

I'll do it safely & naturally, learning to treat the cause, not the symptom (weight gain)

I'm still unsure

7 votes

6 comments