Zonulin → Gut Barrier, Inflammation, and Weight Gain
High levels of Zonulin leads to- Leaky Gut & Inflammation - Elevated zonulin = looser gut barrier. - Toxins, food antigens, and bacteria leak into the bloodstream → immune system stays on high alert. - Chronic low-grade inflammation is directly tied to insulin resistance, fat storage, and slowed metabolism. - direct lead in to Auto Immune Dis-eases. Fluid Retention / Puffiness - - Inflammation increases capillary leakiness and signals the body to retain water. - You see this as puffiness in the face, belly, hands, or ankles. Cravings & Appetite- - Dysregulated gut permeability can alter gut hormones (ghrelin, leptin), driving overeating. - The microbiome also shifts toward calorie-harvesting bacteria when zonulin is high. Enkephalins → Stress, Pain, and Weight Regulation Stress Eating & Reward Pathways - Enkephalins normally calm stress and reduce pain. - When they’re low (from chronic inflammation), stress feels worse. - The brain seeks quick dopamine hits (sugar, processed carbs, alcohol). This fuels weight gain. - Poor enkephalin function worsens sleep quality and increases perceived stress. - Both of these drive up cortisol → more abdominal fat storage, more puffiness. The Zonulin–Enkephalin Loop in Weight Gain & Puffiness 1. Zonulin ↑ → Leaky gut → Inflammation. 2. Inflammation → Weakens enkephalins → more stress, pain, cravings. 3. Low enkephalins → Stress eating & poor recovery → weight gain. 4. Ongoing inflammation → Water retention + puffiness. 5. The cycle repeats, making weight loss feel “impossible” without addressing both gut and nervous system balance. FitnHealthy Tip - - Zonulin makes the body inflamed and puffy. - Enkephalins, when weak, drive stress eating and inactivity. - Together, they create the perfect storm for uncontrolled weight gain and chronic puffiness — even if someone is “dieting.” Who wants a Solution to this NOW? Auto-Immune? Puffiness? Cravings? Weight Gain? No Sleep?