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CHASING GREATNESS

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Castore: Built to Adapt

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3 contributions to Castore: Built to Adapt
EBV Treatment?
Is there some solution or life quality/energy increasment when having the Epstein Barr Virus? Some lifestyle hacks and Supplement/Peptides stack? 🙏
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The Hidden Switch: Why Long COVID Lingers and How to Restart the System Part 3
Mitochondria sit at the heart of long COVID, and their dysfunction explains why symptoms cut across so many systems. These organelles are more than energy factories; they are cellular sentinels that decide whether the body is in growth, defense, or repair mode. During acute infection, mitochondria deliberately shut down high-output energy production and switch into alarm signaling. They fragment, release ROS, and send out distress molecules to coordinate immune activity. In long COVID, that alarm mode never fully resets. Instead of resuming normal energy output, mitochondria remain locked in a fragmented, stressed state that drains vitality. One of the hallmarks is fission dominance. Normally, mitochondria exist in a dynamic balance between fusion and fission. Fusion allows mitochondria to share contents, repair damage, and optimize energy efficiency. Fission is used to isolate damaged segments and remove them through mitophagy. In long haulers, oxidative stress and cardiolipin damage tip the scale toward constant fission. The result is a population of small, inefficient mitochondria that can’t produce steady ATP. It is like breaking a power plant into dozens of tiny generators that each sputter and fail rather than pooling resources into one stable grid. Cardiolipin, the signature phospholipid of the inner mitochondrial membrane, plays a central role here. It stabilizes respiratory chain complexes and maintains cristae structure where ATP synthesis occurs. Viral infections, including COVID, generate excessive ROS that oxidize cardiolipin. Once cardiolipin is oxidized, it loses its ability to anchor electron transport complexes, causing electron leaks and more oxidative stress. This vicious cycle locks mitochondria into dysfunction. Imagine scaffolding inside a factory collapsing machines keep running but with sparks flying and energy leaking at every corner. The downstream effect is impaired electron transport. Complex I and Complex II become bottlenecks, leading to reduced oxidative phosphorylation and increased reliance on glycolysis. This metabolic shift produces excess lactate, explaining the exercise intolerance and post-exertional malaise many long haulers experience. Even mild activity can push lactate high because mitochondria can’t clear the workload efficiently. Patients feel as if their muscles are flooded with acid after the smallest effort, and in truth, their energy systems are behaving like an undertrained athlete running on fumes.
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how is the dose of ss31 and how long to take it?
Typ I Diabetes
Is there something that can be done for a Typ I Diabetes to be healed completely? For example any peptides or special supplements? Thank you 🙏
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Daniel Enderli
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1point to level up
@daniel-enderli-8793
Improvement over everything

Active 13m ago
Joined Aug 1, 2025
Zurich, Switzerland
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