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19 contributions to Castore: Built to Adapt
Most Fatigue Advice Fails Because It Confuses These Two Very Different Problems
Low energy is one of the most common complaints in medicine, coaching, and everyday life, yet it is one of the least precisely understood. People describe it as fatigue, burnout, brain fog, weakness, lack of motivation, or feeling “offline.” Athletes feel it when they cannot train. Patients feel it when they cannot work. High performers feel it when discipline no longer works. The problem is that “low energy” is not a diagnosis. It is a surface description of a system-level failure, and two people can experience nearly identical symptoms while the underlying biology is completely different. Treating them the same way helps one person and harms the other. To understand low energy correctly, you have to stop asking how to boost energy and start asking why energy is being limited in the first place. At the deepest level, there are two dominant failure modes. In one, the body cannot produce enough energy. In the other, the body is deliberately suppressing energy production. The first is mitochondrial damage, a capacity problem. The second is inflammatory inhibition, a regulatory decision. One is a broken engine. The other is a functioning engine with the brakes applied. Subjectively they feel similar. Biologically they are opposites. Everything that follows depends on recognizing which one you are dealing with. A simple model helps. Imagine the body as a car. The mitochondria are the engine. They take fuel and oxygen and convert them into usable energy in the form of ATP. Inflammation acts like the central control computer, deciding how much power the engine is allowed to produce. If the engine is damaged, pressing the accelerator does little. If the computer is limiting output, the engine could perform, but is being intentionally restrained. In both cases the car goes slow. Only one responds to pushing harder. Mitochondria exist inside nearly every cell and are responsible for producing ATP, the molecule that powers muscle contraction, nerve signaling, hormone synthesis, immune regulation, tissue repair, and cognition. Without adequate ATP, nothing in the body functions well. Energy production depends on intact mitochondrial membranes, functioning enzymes, proper redox balance, sufficient oxygen delivery, and a steady supply of micronutrients. When any part of this system is damaged, the maximum amount of energy the body can generate drops. This is not a motivational issue. It is a hard ceiling.
2 likes • 2d
Great article! How would you go about treating an inflammatory inhibition?
Got the Ketone-IQ - What now..
I got the ketone-IQ that @Anthony Castore has talked about. Was shopping and saw it in the store. Feeling a little out of it today, dragging my a$#. Wrkg long hours. Question - Can I do my Lipo Amino Acid Vit B injections and still drink the ketone iq? Would that be overkill... should I do them on separate days?
1 like • 19d
You could use it for a "buzz" as it is essentially the same as Ketone Aid's Hard Ketone product. Delta G is another great brand and the original Ketone monoester.
The Most Important Muscle You Aren’t Training (And Why It Matters)
Let me tell you a story about the most important muscle in your body that almost nobody trains, almost nobody understands, and almost everybody is slowly losing. The diaphragm is not just a breathing muscle. That description is like calling the brain a “thinking organ.” It’s technically true, but it misses the point so badly that it becomes misleading. The diaphragm is a living interface between structure and signal, between chemistry and physics, between voluntary and involuntary control. It is a biological transistor. A gatekeeper. A conductor that coordinates pressure, charge, rhythm, and information across the entire organism. If you understand the diaphragm, you understand how the body integrates itself. If you lose the diaphragm, the body fragments. Let’s start simply, then go deep very deep. At the most basic level, the diaphragm is a dome-shaped sheet of muscle that separates the thoracic cavity from the abdominal cavity. When it contracts, it descends. When it relaxes, it recoils upward. This movement changes pressure in the chest and abdomen and drives airflow in and out of the lungs. That’s the textbook version. It’s also the least interesting. The diaphragm is the only skeletal muscle in the body that is both voluntary and involuntary. You can control it, but it doesn’t need you. That alone should make you suspicious that it sits at a crossroads no other muscle occupies. Embedded in and passing through the diaphragm are some of the most important structures in the body: the inferior vena cava, the esophagus, the aorta, lymphatic channels, and dense autonomic nerve plexuses. Every breath mechanically massages blood, lymph, and nerves. This is not a side effect. This is the design. Each diaphragmatic contraction creates a pressure wave. That wave propagates through fluid-filled tissues, fascia, and organs. Pressure waves in biological tissue are not just mechanical events. They are information-bearing phenomena. They alter ion channel behavior, membrane tension, protein conformation, and mitochondrial function.
3 likes • Jan 4
The isocapnic device has been a game changer for me. Highly recommend!
peptide source
I’m wondering where everyone gets their injectible peptides from? Anthony, does SSRP have a preferred source that us in the community could purchase from? Any online clinic where a virtual consult could be done and the peptides prescribed from a compounding pharmacy and shipped to our residence? I have a functional medicine doctor in miami but he requires you pick them up and they are already reconstituted which affects their expiration.
1 like • Dec '25
aprhealthsolutions.com and use code "bike" to save some money. Great products, reasonable pricing, and extensive testing.
ATX-304
Whose used this? I have some, running 200mg a day, deffo sweat a bit more during cardio, if I combine it with SLU I get a noticeable increase in body temp. Not sure on dosing as see people saying once per day, multiple times etc. Anyone got experiences and share what they have found?
2 likes • Dec '25
@W Andrews I did not change diet as I already eat over 1000 grams of carbs a day to fuel my training load. No noticeable change in body composition (I am 7% BF).
3 likes • Dec '25
Check out Duffin and Anthony's latest podcast. Sounds like you need to fix your redox balance before continuing to use these compounds.
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Trevor Bouchard
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87points to level up
@trevor-bouchard-2142
Train like your life depends on it

Active 1h ago
Joined Sep 10, 2025
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