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4 contributions to Castore: Built to Adapt
Healthcare Appeals and Coverage Update...
Sharing notification information received in my Healthcare communication. New rule went into affect Dec 24, 2025. This only affects "postal mailing important Healthcare paperwork". Many ppl in this community discuss Healthcare issues, getting treatments, having surgeries - be aware of this new rule. The USPS has changed what a 'postmark' means when mailing items. It now means that when the letter reaches an automated facility, that will be the recognized date. It is no longer tied to when you drop your mail off. How this affects Healthcare and ppl getting affected when the mail appears to arrive late, past deadlines - IF you are replying to a Healthcare appeal; have a deadline; prior authorization deadlines; Medicare notices; Rx paperwork; Medicaid, Medicare, Commercial Insurance renewals; Benefit interruptions; Loss of coverage; Patients paying bills, Applying for or renewing healthcare insurance, etc... Late appeals get denied. Denied appeals delay care. Late Healthcare insurance renewals get denied, coverage lost. This can happen when mail is postmarked days after submission. This new rule shifts the risk back to the patient. The Healthcare process is tied to deadlines. So if you are postal mailing anything "time sensitive", mail early OR walk inside the post office and ask for a manual postmark. If they say they are too busy, etc... - then ask for a receipt. Using the blue mail boxes or any usps drop off slots - are not safe to ensure you will get a postmark for that day nor the following days. OLD WAY: Postmark often reflected the date dropped in a mailbox or given to a carrier. NEW WAY: Mail is sent to larger regional centers, stamped during the first automated sort, and that's the date shown, which can be days later.
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OpenAI launched ChatGPT Health!!
Hello Everyone šŸ‘‹ - Some of you may know already. OpenAI launched ChatGPT Health!! It was built to answer health and wellness questions for consumers. My understanding is that it was beta tested by over 600 MD physicians in over 60 countries to ensure accuracy with results, etc... I know we all have used AI platforms to field many of our health questions, even for peptide questions. AI is transforming speed and breadth of accessibility to information; we desperately need this access in the healthcare industry so we are informed, know the right questions to ask, better understanding of our biologics and hold the physicians accountable for a more comprehensive, informative and collaborative prognosis. We pay good šŸ’°, that is hard earned and it is after-tax dollars, to have a healthier, more active lifestyle. And our Healthcare system has failed us by prioritizing net profit over preventative care initiatives, holistic integrative options, fair - honest knowledge share. I will leave it there b/c I am getting riled up when it comes to this topic 😊 This will not be the first and only healthcare AI dB knowledge platform. You can bet many will create more. AI developments are moving at lightening speed. So, here is one of the links - Enjoy šŸ’•https://help.openai.com/en/articles/20001036-what-is-chatgpt-health - šŸ«‚šŸ¤—
0 likes • 2d
@Steven Goodspeed Thanks for sharing this link for ChatGpt Peptide. This is a great tool also. What is the source of this Gpt? I've inquired before, but haven't gotten an answer.
0 likes • 2d
@Steven Goodspeed Okay, I read Dr. Seeds book, great book. In Reddit, someone created another GPT for peptides and this one was based on Jay Campbell book and broscience stuff. Not interested at all in that GPT...lol.
Per Dr. Seeds _ Methylene Blue is not reliable measure of damaged mitochondria
@Anthony Castore Can you provide your feedback on the below... it is Dr. Seeds feedback on using methylene blue as an indicator for function status of Mitochondria. @Anthony Castore *** Dr. Seeds Feedback - Short answer: No. Methylene blue is not a safe or reliable non-medical way to check liver or kidney function. Here’s a clear explanation without getting technical or giving instructions. Why methylene blue does not work as a liver/kidney test 1. It’s not a diagnostic marker Methylene blue is a dye and redox-active compound. Changes in urine color after exposure do not reflect how well your liver or kidneys are working. - Blue or green urine ≠ good or bad kidney function - Faster or slower color change ≠ liver performance Those changes mainly reflect: - How the dye is processed chemically - Hydration status - Gut absorption - Individual metabolism Not organ health. 2. The body handles it in multiple ways Methylene blue: - Is partially metabolized in the liver - Is partially excreted by the kidneys - Is chemically reduced to leucomethylene blue (colorless) Because of this, you cannot isolate liver vs kidney function based on what you see. Too many variables = no meaningful conclusion. 3. Color changes are misleading Urine color after exposure can change due to: - Dose size - Timing - Gut absorption - Gut bacteria - Hydration - Other foods, dyes, or supplements This makes it uninterpretable outside a controlled medical setting. Historical / medical context (important distinction) In the past, methylene blue was used by doctors for very specific purposes, such as: - Certain lab-based kidney flow studies (obsolete now) - Specialized surgical or imaging contexts āš ļø These were: - Controlled - Measured - Clinically supervisedNot self-tests. Modern medicine does not use methylene blue to assess routine liver or kidney function. Safety note (important)
2 likes • 13d
@Anthony Castore I have his actual book. But below is the GPT that was created sourced from Dr. Seeds book. We use it to easily search for certain things from Dr. Seeds book. I am not sure who created this GPT that is sourced from his book. https://chatgpt.com/g/g-zKizzcahz-peptidegpt
2 likes • 13d
@Anthony Castore Okay - I understand much better now. I misunderstood your information on methylene blue. This clears it up. I follow much of your work and it has shaped my peptide journey in a positive way. Thank You @Anthony Castore šŸ’Æ
Understanding Redox: The Last Article You Will Ever Need To Read And The Keys To The Kingdom
Redox is one of those concepts that everyone has heard of but very few people truly grasp, and yet almost everything in human physiology depends on it. For trainers and clinicians, redox is the hidden language that tells you why someone can train hard one day and crash the next, why fat loss stalls even with perfect macros, why motivation drops without a psychological trigger, why inflammation rises mysteriously, or why protocols that used to work suddenly stop producing results. Redox isn’t a supplement, a lab marker, or a buzzword. It is the most fundamental process life uses to create energy, repair damage, and adapt to stress. When redox flows, people adapt. When it gets stuck, people stagnate. Understanding redox at a deep level gives you the ability to see beneath symptoms, beneath lab markers, beneath surface-level physiology, and down into the actual physics and molecular dynamics that determine whether a person is moving toward resilience or toward dysfunction. This redox deep dive will walk through what redox is, why it matters, how it gets stuck, what ā€œstuckā€ actually means at the molecular level, and how different stressors push the system into different dysfunctional patterns. Throughout this, I’ll use analogies and imagery that make the invisible world of electrons and membranes feel intuitive and concrete, allowing you to visualize exactly what is happening inside cells when energy is being made—or when the system jams. You’ll see how mitochondrial membranes behave like electrical waterfalls, how electrons move like crowds of people flowing through hallways, how redox imbalance can freeze a system the way traffic jams choke off a city, and how trainers and clinicians unintentionally worsen stuck redox by focusing on quantity of activity instead of the phase of the system. Redox is short for reduction and oxidation the transfer of electrons. To understand why this matters, imagine every cell in your body as a tiny city. Energy isn’t created in one burst; it’s created by passing electrons down a series of steps, like handing a baton from one runner to the next. Reduction is when a molecule gains electrons, oxidation is when it loses electrons. In biology, electrons fall down an energetic staircase inside mitochondria called the electron transport chain. As electrons move, they power tiny pumps that push protons across a membrane, building what can be imagined as a ā€œpressure gradientā€ or electrical tension. This tension the mitochondrial membrane potential is like the charged battery that lets ATP synthase spin and generate ATP. Think of it like water flowing through a hydroelectric dam: the higher the water pressure behind the dam, the more electricity you can generate. If the water level drops too low, the turbine stops. If the dam wall gets blocked and pressure rises too high, the system becomes dangerous. Mitochondria work exactly the same way. Redox is the management of electron flow across the mitochondrial inner membrane. Everything hinges on whether electrons are moving, whether they have somewhere to go, whether the membrane potential is balanced, and whether the cell can match energy demand with supply.
1 like • 23d
@Anthony Castore Great article. You mention SS-31, MOTS-c, Methylene Blue. Then you say that none of them will work if the system is too stuck. How does one go about getting the system unstuck so the SS-31, MOT-c, Methylene Blue - will work and be effective? From what I've read - I should start phase 1, Methyle Blue for 3-7 days; then phase 2, SS-31 + NMN for 4 wks; phase 3, for 5-10 wks - stop SS-31, start MOTS-C , continue NMN but can do NAD+ injections as boosters as needed. What should be done before starting this mitochondrial protocol if they won't work because the system is too stuck?
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Taylor S
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11points to level up
@latrice-s-6915
Awesome individual, all about factual information and being responsive.

Active 1h ago
Joined Nov 29, 2025
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