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The Peptide Daily Brief

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Castore: Built to Adapt

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4 contributions to Castore: Built to Adapt
Memberships Options: Read This If You’re New or Deciding How to Engage More Deeply
This community exists to correct a problem I see every day: smart, motivated people making avoidable mistakes because they are reacting to information instead of reasoning through it. Everything here is built around clear thinking, proper sequencing, and confident restraint. There are several ways to engage. Each one is designed for a different level of responsibility. The question is not whether to invest. The question is where you are right now. The Cellular Intelligence Circle For Orientation, Context, and Staying Current The Circle is where confusion gets resolved before it turns into action. This is the right place if you want to: - Understand emerging science without overreacting to it - Learn how decisions are actually weighed - Separate signal from noise - Avoid unnecessary intervention It is a content-first environment designed to compound over time. Membership provides access to a growing, curated body of work that functions as a reference library, not a feed to keep up with. Inside the Circle: - Peptide of the Month (mechanism, context, restraint) - Protocol and case reasoning breakdowns - Science article reviews focused on interpretation, not hype - Monthly live Q and A - Periodic synthesis webinars The Circle is not coaching. It is not protocol delivery. It is where judgment is built. Pricing - $79 per month - $219 for three months - $499 for twelve months This level is appropriate when your primary goal is orientation, understanding, and staying sharp. One-Time Consultations For Specific Decisions. Consultations exist for moments when a decision needs to be handled correctly. They focus on: - Identifying what actually matters - Removing unnecessary complexity - Clarifying what not to do Pricing - One hour consultation: $350 - One hour consultation with follow-up: $500 This option makes sense when a single decision needs careful thought. Ongoing Advisory Core For Continuity and Guardrails. This is for people who no longer want to think through complex decisions in isolation.
1 like • 6d
Does “send me a DM” mean initiate a chat here on Skool or something else? I may be ignorant of how to express interest in the inner circle or how to initiate payment. I have tried via chat but I may be doing something wrong.
0 likes • 6d
@Anthony Castore I’m sure I’m doing something wrong here.
Mitochondrial health/efficiency (without peptides)
Hi all. Am curious if folks have protocols to improve mitochondrial efficiency without using peptides. Ie eating sardines, taking coq10, ensuring 7-9 hours of sleep etc. Would be very interested in understanding how Folks think about what they are taking (intended effect), timing and dosage. I saw a few historical posts touching on this but nothing that got into the details Of the why and how.
3 likes • 17d
Also PQQ can help. Coq10 (Ubiquinol) and Alpha Omega M3 is great. C60 for a while initially I’ve heard from @Chris Duffin can help and I will be trying soon.
OpenAI launched ChatGPT Health!!
Hello Everyone 👋 - Some of you may know already. OpenAI launched ChatGPT Health!! It was built to answer health and wellness questions for consumers. My understanding is that it was beta tested by over 600 MD physicians in over 60 countries to ensure accuracy with results, etc... I know we all have used AI platforms to field many of our health questions, even for peptide questions. AI is transforming speed and breadth of accessibility to information; we desperately need this access in the healthcare industry so we are informed, know the right questions to ask, better understanding of our biologics and hold the physicians accountable for a more comprehensive, informative and collaborative prognosis. We pay good 💰, that is hard earned and it is after-tax dollars, to have a healthier, more active lifestyle. And our Healthcare system has failed us by prioritizing net profit over preventative care initiatives, holistic integrative options, fair - honest knowledge share. I will leave it there b/c I am getting riled up when it comes to this topic 😊 This will not be the first and only healthcare AI dB knowledge platform. You can bet many will create more. AI developments are moving at lightening speed. So, here is one of the links - Enjoy 💕https://help.openai.com/en/articles/20001036-what-is-chatgpt-health - 🫂🤗
0 likes • Jan 15
https://chatgpt.com/g/g-zKizzcahz-peptidegpt Not the same thing. Just fyi.
0 likes • Jan 15
@Taylor S tbh I can’t recall where I got it but my understanding is it is trained on Dr. Seeds’ work mostly or exclusively I’m not certain. I’m sure I found it on Skool somewhere and I’d give credit if I could.
The Hidden Recycling Loop That Controls Estrogen (And Why Anti-Estrogens Fail)
Bile acids and estrogen are linked not because the body made a mistake, but because it is extraordinarily efficient. Human physiology is built around conservation. Anything energetically expensive or biologically powerful is reused whenever possible. Cholesterol is reused. Bile acids are reused. Steroid hormones like estrogen are reused. The liver and gut work together as a recycling plant, constantly deciding what to keep, what to modify, and what to throw away. Estrogen and bile acids happen to share the same conveyor belt. This is why problems with digestion, stool, gallbladder function, thyroid output, stress, or the microbiome so often show up as “hormone issues.” The hormones are downstream. The traffic system is upstream. To understand the connection, we start with the simplest possible truth: estrogen does not simply rise or fall on its own. Estrogen exposure is the result of production, conversion, binding, recycling, and elimination. Bile acids influence three of those five steps. That alone explains why anti-estrogen strategies so often fail. Bile acids are usually taught as digestive detergents. You eat fat, the gallbladder squeezes, bile comes out, fats get emulsified, end of story. That explanation is incomplete. Bile acids are also signaling molecules that talk directly to the liver, the gut, immune cells, and the microbiome. They regulate which bacteria survive. They turn genes on and off. They decide how aggressively the liver detoxifies hormones. Think of bile acids less like dish soap and more like traffic police. They don’t just clean up fat. They control flow. Estrogen’s journey through the body follows a predictable arc. Estrogen is synthesized or converted from precursors, used in tissues like breast, bone, brain, muscle, and reproductive organs, and then whatever is left over is sent to the liver. The liver’s job is not to destroy estrogen but to neutralize it temporarily. It does this by conjugating estrogen, mainly through glucuronidation and sulfation. These chemical tags make estrogen water-soluble and biologically quieter.
2 likes • Dec '25
@Sean Brauer NAC can help. https://www.lifeextension.com/search#q=advanced%20milk%20thistle&t=coveo4A2453FD Is also great.
1-4 of 4
Steven Goodspeed
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14points to level up
@steven-goodspeed-1069
Learning

Active 3h ago
Joined Dec 9, 2025
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