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7 contributions to Castore: Built to Adapt
Small Umbilical Hernia - Surgery 04.13.2026
52-yr female. I work out 5-6 days a week. I’m lean and well-muscled. I want to accelerate healing as much as I can w/out impacting recovery and increasing recurrence risk. They are going to do an open repair (direct incision with mesh) because I'm lean and have strong abdominals. The surgeon has observed faster recovery and fewer recurrences with this method. Note - it's fat/fascia vs. intestinal protrusion. Planning on: BPC/TB/KPV near stitches; Red light; Bio-regen from BLL; Other suggestions? Will need to order stuff, so there will be a few days' lag on what I can start. Also, if anyone has experience with recovery and training timelines, I would love the information Thank you!!!! Kate
0 likes • 10d
@Kate Bolseth best of luck. Sounds like a solid plan.
Glutathione
How are we dosing glutathione?
0 likes • 18d
@Jacob Leister I’m trying a process of a monthly 1,200 IV with daily niacin afterwards. It’s all about recovery for my support system.
1 like • 17d
@Seth Dinoi i have started trialling a monthly moles injection IV with niacin as daily support in between. I am in the midst of a heavy training program that last until mid may so I take it to help recovery and fight off any potential illness that might creep in because of heavy training.
PART 1 — The Shift: Supplements Are Signals, Not Solutions
Most people approach supplements the same way they approach a checklist. Energy is low, so they take something for energy. Sleep is off, so they take something for sleep. Inflammation is present, so they take something to reduce inflammation. On the surface, that feels logical. In practice, it’s why so many people stay stuck. Take a common example. Someone uses magnesium for sleep and it works for a week or two, then the effect fades. The assumption is that the dose is wrong or the product isn’t strong enough. Almost never does anyone ask a better question. What changed in the system that made it stop working? The body is not a collection of independent problems waiting to be patched. It is an integrated, adaptive system built around one central priority: managing energy and information flow. Every symptom you experience is an output of that system. Not random. Not isolated. It is a response. When you take a supplement, you are not fixing anything. You are introducing a signal into that system. That signal interacts with cellular pathways, shifts chemistry, and influences how the body allocates resources. Sometimes that produces a desirable outcome. Sometimes it doesn’t. And sometimes it works briefly before the system adapts and you are right back where you started. This is the point where most protocols quietly fail. This is where most people get stuck. They judge supplements based on whether they work instead of asking a more important question. What did this actually do to the system? If you zoom in at the cellular level, the picture becomes clearer. Every cell is constantly managing the movement of electrons through metabolic pathways, essentially how cells generate energy. That flow determines whether energy is produced efficiently or whether stress signals begin to accumulate. Mitochondria sit at the center of this process, integrating fuel availability, oxygen, and signaling inputs to decide how energy gets generated and how the cell responds. When pressure builds at key points in the system, particularly around the electron transport chain, the balance between electron supply and redox capacity begins to shift, and signaling follows. The system moves away from performance and toward protection.
1 like • 20d
@Anthony Castore lots for me to think about there. Thanks
1 like • 20d
@Anthony Castore looking forward to it 🙏
Glycocalyx: The Missing Layer In Human Performance Part 5
You don’t fix this system by adding more. You fix it by changing the environment it lives in. That is where most people get this wrong. They hear about something like the glycocalyx and immediately start looking for the thing that rebuilds it. A supplement, a peptide, a compound that directly restores the layer. That is not how this works. You do not rebuild the glycocalyx directly. You rebuild the conditions that allow it to exist, stabilize, and function the way it is supposed to. If you have been doing a lot right but still feel like something is missing in your energy, recovery, or performance, this is often where the gap is. By now you understand what the glycocalyx is, what it does, how it breaks down, and how to recognize when it is not functioning well. Now the question becomes what direction you need to move in. If you want a simple way to approach this, think in four steps: remove the pressure, restore the signals, rebuild the structure, and refine the system. Everything fits into one of those. Start with removing the pressure. You cannot rebuild something that is still being actively broken down. If blood sugar is fluctuating wildly, that needs to be stabilized, not necessarily through restriction alone, but by improving how the body handles nutrients. Consistent meals, appropriate carbohydrate timing, and metabolic flexibility all matter here. If there is ongoing low grade inflammation, you need to identify the source. This could be coming from the gut, poor sleep, chronic stress, or unresolved immune activation. The goal is not to suppress inflammation blindly, but to remove the drivers that keep the system activated. If recovery is compromised, nothing else will hold. Sleep, circadian rhythm, and overall stress load directly influence how this system maintains itself. This is where most people go wrong. They skip straight to advanced tools. But when you build on an unstable foundation, the system continues to erode underneath whatever you add.
2 likes • 21d
Fascinating series on something I’d never heard of before but makes a whole lot of sense. Thanks @Anthony Castore for taking the time to go into such depth.
Glycocalyx: The Missing Layer In Human Performance Part 3
The damage you are worried about is not what is affecting you most. Most damage to this system does not arrive as an event. It arrives as erosion. Not one big moment you can point to, but thousands of small inputs that slowly reshape how your body works at the most important interface it has. If Part 1 showed you the layer and Part 2 showed you what it does, this is where things get real. The glycocalyx is not failing randomly. It is responding to the environment you create every day. Most of the inputs that degrade it are not extreme. They are normal. Before we break those down, you need to understand one distinction that changes how you see everything that follows. There is acute damage, and there is chronic erosion. Acute damage is fast and obvious. It shows up in things like severe infection, trauma, or ischemia. In those situations, the glycocalyx can break down rapidly. Pieces of it are shed into circulation, the interface loses control, and the system becomes unstable almost immediately. Chronic erosion is different. It is slower, quieter, and far more common. It does not remove the glycocalyx all at once. It changes it. It can make it thinner, more fragile, less organized, or simply less functional. The system is still there. It just does not work the way it should. Most people are not dealing with catastrophic loss. They are living in a state of gradual erosion. If you have ever noticed your energy fluctuate for no clear reason, your workouts feel inconsistent despite similar effort, or your recovery shifts from week to week, you have already experienced what this looks like. You can think of the drivers of this erosion in four simple categories. Chemical stress, inflammatory stress, mechanical deprivation, and recovery failure. Everything you are about to read fits into one of those. Start with chemical stress. Blood sugar is not just fuel. It is a chemical environment. When glucose rises repeatedly, especially in large swings, it changes how proteins and sugar chains behave at the glycocalyx. They become less flexible and more prone to dysfunction. It is not just high blood sugar that matters. It is the variability. Repeated spikes and crashes create a kind of metabolic whiplash that the system has to absorb.
0 likes • 23d
@Anthony Castore this series has been fascinating. Thanks
1 like • 23d
@Curtis Smith great input and relatable for many 👏
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Roy Zimmerhansl
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12points to level up
@roy-zimmerhansl-6507
Healthier than ever at 65, training and learning

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Joined Mar 26, 2026
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