I was exploring some ideas I had, regarding BAM15 and Meth Blue with the deep think function of gemini. Here is what it spit out: "The main synergy lies in maximizing electron flow and oxygen consumption (hypermetabolism). This is achieved through complementary mechanisms. A. Supra-maximal Respiration and Overcoming Bottlenecks - BAM15 (Releasing the Brakes): BAM15 dissipates the proton gradient, removing the resistance against which the electron transport chain (ETC) works. The ETC accelerates to its maximum, limited only by its own enzymatic capacity. - Methylene Blue (Supercharging the Engine): When the native ETC reaches its capacity or when bottlenecks exist (e.g., at Complex I or III), MB serves as an alternative pathway. It takes electrons from NADH and shunts them past these bottlenecks to Cytochrome C. - Synergistic Effect: BAM15 creates an unlimited demand for electron flow; MB increases the capacity for this flow beyond the native maximum. This leads to a "supra-maximal" metabolic rate. B. Synergy in NADH Regeneration (Substrate Supply) For glycolysis and the Krebs cycle (which burn nutrients) to proceed quickly, NAD+ must be continuously regenerated from NADH. The ETC is the primary site of this regeneration. - Synergistic Effect: By massively accelerating the ETC together, BAM15 and MB oxidize NADH back to NAD+ extremely quickly. This prevents a metabolic "traffic jam" and allows the upstream metabolic pathways to also run at maximum speed. C. Synergy in Reducing Reverse Electron Transport (RET) A major source of mitochondrial ROS is "Reverse Electron Transport" (RET). This occurs when the proton gradient is very high and the ETC is blocked, causing electrons to flow "backwards" through Complex I and generate massive amounts of superoxide. - Synergistic Effect: BAM15 drastically lowers the proton gradient, effectively blocking RET. MB oxidizes the NADH pool, which also reduces the "traffic jam" that drives RET. Together, they eliminate this specific source of oxidative stress.

COVID long hauler syndrome cannot be fully understood without looking at how the immune system has been reshaped. In acute infection, the immune response is meant to be sharp and temporary. It mobilizes T cells, activates innate pathways, clears the virus, and then turns off. But in many long haulers, this reset never occurs. Instead, the immune system becomes locked in an over-activated but ineffective state. The soldiers are still on the battlefield, but they are exhausted, misfiring, and sometimes even attacking the wrong targets. One of the key features is T cell exhaustion. Normally, T cells expand, attack, and then contract back into memory cells. In long COVID, repeated exposure to viral fragments and persistent inflammation keeps T cells in a state of hyperstimulation. Over time, they express inhibitory receptors like PD-1 and lose their ability to function. It is as if the army has stayed on the front lines so long that they are too tired to fight but too conditioned to retreat. This leaves the host vulnerable both to ongoing low-level viral persistence and to runaway inflammation. Mast cells also play a crucial role. These are the immune system’s alarm towers, releasing histamine, cytokines, and other mediators that influence blood vessels, nerves, and connective tissue. COVID appears to leave mast cells hypersensitive. They degranulate too easily, releasing histamine at inappropriate times. This helps explain symptoms like flushing, heart palpitations, dizziness, brain fog, and gastrointestinal disturbance. The mast cell is supposed to be a smoke detector, but in long COVID it is so sensitive that even steam from a shower sets it off. Autoimmunity is another dimension. Some patients develop antibodies against their own tissues after infection. In particular, antibodies against ACE2 receptors, beta-adrenergic receptors, or mitochondrial proteins have been detected. These can directly disrupt vascular tone, autonomic signaling, and cellular energy production. Autoantibodies are like friendly fire on the battlefield your own troops accidentally targeting the home base.

Hey folks! I am trying to learn more about 5-amino-1mq. - Which purpose does it serve in your stack? H - How do you dose it? - What have you experienced using it?

Here's another group project that I discussed with @Anthony Castore and we agreed having the group work on this together would allow us to receive the best input and put together the best reference list for us all to use. Because the supplement industry is both noisy and inconsistent the distinction between quality/efficacious supplements/compounds and those that are not is often times a very difficult task: some compounds are a commodity-like (creatine monohydrate, bulk amino acids), where purity is relatively easy to achieve and there’s little advantage paying extra for a “designer” label. Other categories — especially lipids (fish oil), fat-soluble antioxidants (CoQ10, carotenoids), or bioactives with low natural stability (PQQ, Urolithin A) — live or die by formulation, raw material source, and quality control. A couple principles that might help as we consider our list: 1. Is it chemically simple or complex? Creatine: single molecule, stable, easy to verify → brand doesn’t matter much if third-party tested. Fish oil, plasmalogens, 1-MNA: unstable lipids or niche molecules → form (TG vs EE vs PC-bound) and oxidation state matter a lot. 2. Does delivery change absorption? Ubiquinol vs Ubiquinone: redox state and carrier lipids improve bioavailability. Liposomal formulations can genuinely help poorly absorbed compounds, but not everything benefits. 3. Is there independent validation? Many of the “designer” claims for things like PQQ, Apigenin, Urolithin A aren’t well-backed by head-to-head human data. In these cases, the real differentiator is whether the company does third-party testing for purity, heavy metals, and stability. 4. Follow the raw material suppliers. Most of the industry is built on the same raw material suppliers (for example, Kaneka for CoQ10, Mitopure for Urolithin A). If a product sources from a top supplier, you’re usually getting the same active regardless of label. The “Amazon brands” like Nutricost or Toniiq can be perfectly fine when they disclose sourcing and batch testing.

Something that i don't see addressed much along the longevity / biohacking / bodybuilding landscape is in-depth discussions, protocols, prevention or the chronic disease it's self - especially considering how important it is to daily life. @Anthony Castore Can you do a deep dive on this - addressing prevention, or peptides/bio regulators to protect the kidneys ?