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Coming Off a GLP-1? Don't Make This Mistake 🚨
If you're thinking about stopping your GLP-1 for any reason—whether it's cost, you've hit your goal, or something else—please don't quit cold turkey. You've probably heard the claim that you will regain all the weight you lost when stopping a GLP-1, and it's simply not true. Here's why this matters and how to do it right. What's Actually Happening in Your Body GLP-1 peptides work by mimicking a natural hormone that tells your brain "you're full." Over time at higher doses, your body adapts to that level of signaling. When you suddenly remove it, your brain essentially goes from hearing a loud "stop eating" signal to near silence overnight. The result? Your hunger doesn't just return—it often comes back with a vengeance. This is why so many people regain weight rapidly after stopping abruptly. The Smart Approach: Titrate Down The same way you titrated up, titrate back down. Every 2-4 weeks, reduce your dose by roughly half OR drop by 1-2 mg (depending on what you're using). This gives your body time to recalibrate at each level. Example timeline: - Week 1-2: Full dose → Half dose - Week 3-4: Adjust to the new hunger level - Week 5-6: Half again or drop another 1-2 mg - Continue until you're at the lowest dose, then stop Why This Works At each step down, you'll feel a slight increase in hunger—but it's manageable. Your brain gets time to readjust to lower levels of satiety signaling gradually, rather than being thrown into the deep end. Think of it like slowly turning down the volume instead of hitting mute. Stack the Odds in Your Favor As you taper, support your body with lifestyle factors: - Protein first – Aim for 30-40g per meal. Protein is the most satiating macronutrient - Fiber up – Vegetables, legumes, and whole grains keep you fuller longer - Whole foods over processed – Less hyperpalatable foods = fewer cravings - Stay hydrated – Thirst often masquerades as hunger These habits matter MORE as your GLP-1 dose decreases. Build them now while you still have the appetite suppression working in your favor.
Coming Off a GLP-1? Don't Make This Mistake 🚨
0 likes • 4h
@Danielle Ward I'm aware. My ex-husband got buried in a trench cave in on the job as an electrician and in the 10 yrs we were married, he had something like 23 different surgeries just for his knee. He has also had a pacemaker/defibrillator put in, and a few other fun things. As for myself I have had multiple surgeries and procedures as well. I truly wish I did not have the medical knowledge that I do because it came at a heavy cost. I won't even get into being my grandma's caregiver through her procedures & end of life as well as being my mother's POA for all her medical issues including the kidney failure which was a wild ride. I honestly have never run into a regular person such as myself that has been through or been a party to as many medical procedures, conditions, and medical terminology & medications. It's a blessing as far as being more educated but a royal pain is the a$$ as far as what I went through for that education. Funny sidenote, my ex-husband's ortho was also a licensed pharmacist because he wanted exact knowledge of everything he prescribed to his patients, so we got a healthy dose of Rx drug knowledge too. Lol. My life falls into the category of; you just can't make this stuff up. 😆😆😆
0 likes • 2h
@Danielle Ward That sounds horrible. I had gastro reflux horribly for years. I was on 3 different meds at one point before discovering that L-Glutamine actually heals the stomach. I went and got a HUGE bottle and after daily use came off my meds completely. I also have a hiatal hernia. Now I just need to watch the types of food I eat so as to not aggravate it like tomato-based things, sugar, and for me - gluten. Breads & things sit in my stomach like a rock for like 6 hours. Have you ever had your stomach acid tested? For me it wasn't that I had too much it was that I had too little and things weren't getting digested. I typically never eat past 3:30 pm M-F and on the weekends not past 4:30. Based on bathroom habits as well as stomach rumbling in the morning I am fairly certain my stomach is empty. Also, based on the umpteen different surgeries & procedures I've had. I also struggle to east 1,000 calories a day too. I just don't feel the need to eat and sometimes have to force it.
When to Actually Add Energy Peptides to Your GLP-1 Protocol (Step-by-Step)
RESEARCH USE ONLY: The peptides discussed in this post are for research purposes only and are not intended for human consumption. This information is educational and should not be considered medical advice. Consult with a qualified healthcare provider before starting any peptide protocol. One of the most common questions I get: "Derek, when should I add energy peptides? Which ones? And in what order?" Here's the honest answer most people don't want to hear — if weight is coming off and your energy feels good, you don't need any of these yet. Seriously. Don't fix what isn't broken. GLP-1s are doing their job, your body is responding, ride that wave. Energy peptides are a tool for when the basics aren't enough anymore. They are not a starting point. So let's walk through this the right way, one step at a time. ——————————————— STEP 1: LET THE GLP-1 DO ITS JOB When you first start a GLP-1, your body is adjusting. Appetite drops, eating patterns shift, and yes, energy might fluctuate a little. That's completely normal. Give it time. Ask yourself: → Is my weight consistently trending down week to week? → Can I get through my day without crashing? → Am I sleeping reasonably well? ✅ If things are moving in the right direction, stay right here. There is no trophy for adding more peptides faster. The goal is reaching your target weight, and if you're getting there, you're winning. You do NOT have to move to Step 2. ——————————————— STEP 2: DIAL IN YOUR LIFESTYLE FOUNDATIONS If energy starts dipping or weight loss stalls, your first move is NOT adding a peptide. It's auditing the basics. I can't stress this enough. Nine times out of ten, the issue is one of these three things: 1️⃣ CARDIO Even 20-30 minutes of walking daily makes a massive difference in energy and metabolic health on GLP-1s. You don't need to run marathons. Just move consistently. 2️⃣ NUTRITION This is the big one. On a GLP-1 you're eating less, which means every bite matters more. You need adequate protein (aim for 0.7-1g per pound of bodyweight) to protect muscle mass, and enough carbohydrates around your workouts to actually fuel your training. A lot of the "energy crash" people blame on GLP-1s is actually just underfueling.
When to Actually Add Energy Peptides to Your GLP-1 Protocol (Step-by-Step)
0 likes • 2h
So what if you added SS-31 then NAD+ for reasons other than to gain energy or break a weight loss stall? I think sometimes we may fixate on one aspect of these peptides. I added SS-31 after 2 cycles of Fox to optimize my mitochondria after the Fox cleared out any dead cells that were hanging around. I did it as a kind of new year reset. I added back in the NAD & glutathione because I am 59 years old and wanted the other benefits those peptides offer. If I needed more energy, I would've simply grabbed my matcha powder and creatine. The bonus of extra energy is a blessing and a curse. Nice during the day but a pain in the rear to still be amped up at 8 pm. Just my opinion but I think there are too many people who look to peptides to be the magic cure. Need energy? There's a peptide for that. Need bigger faster gains? There's a peptide for that. Want to sleep better or be able to relax more? There's a peptide for that too. I love my peptides as much as the next person; they were a Godsend and definitely have their value. HOWEVER, need to relax & get more sleep? There are many all-natural organic holistic herbal teas (not just chamomile) that calm your mind/anxiety, help to induce sleep, etc. that actually do work if you give them the chance along with behavior modification. Melatonin in doses up to 10-15 mg if needed can get you the sound sleep you need too. Just as an example. I agree with you wholeheartedly on the subject of, we need to examine our motives, our habits, etc. more honestly and in depth before reaching for the next great peptide to "fix it."
Peptide Price Taken Down… Again 🫠
Good morning everyone. If you tried to use the price tool on PeptidePrice.store this morning, you probably saw a message saying hosting was temporarily disabled. I want to be fully transparent about what happened. My hosting provider — based overseas in Iceland — flagged the site and asked me to provide additional proof that I don't sell peptides directly. Which is crazy, because you know PeptidePrice.store is a price comparison tool. That's it. If you've been around for a while, this might sound familiar. A couple months ago Netlify completely took down the site and tried to hold the domain hostage over what they called "dangerous activity." That forced me to migrate everything to a new provider, which is the one that just gave me trouble again. The good news — the site is back live. I've already looked into additional hosting options to make sure we have backup plans in place so this doesn't keep disrupting things for you guys. Building a platform like this in the peptide space comes with challenges that most people never see. Censorship, deplatforming, hosting issues — it's a constant battle. But I'm not going anywhere. This community and this tool mean too much to me to let a hosting provider shut us down. Thank you for sticking with me through all these bumps along the way. It means more than you know. ❤️
Peptide Price Taken Down… Again 🫠
1 like • 4h
@Nancy Lopez Olivera I don't think that will happen. There are over 400 known peptides if I remember correctly & peptide use has been around for decades. The explosion of GLPs and the shortage has shown a light on peptides that until now unless you were a wealthy housewife or serious body builder you just had no real knowledge of them. I think the major concerns are the GLPs and things that are being brought to market like SS-31. Everything else is pretty much safe from scrutiny. For now.
0 likes • 4h
@P R Definitely agree with you on that.
Quick poll: Where are you at in your research journey?
I want to make sure the content I'm creating actually helps with YOUR goals, so I'm curious—where are you at right now? Drop your answer below, and if you want to share more about your journey so far, I'd love to hear it. As for me: Started at 250, got down to 170 without peptides, and maintained for about four years. Now I'm in a new chapter—intentionally trying to add muscle for the first time. It's 100% a mental game. Yes, I've put on some body fat in the process, but muscle takes way longer to build than fat takes to lose. You have to commit to the long game. And honestly? Muscle mass is the real key to longevity. The other piece I don't talk about as much: I dealt with binge eating for years. That maintenance phase wasn't just about weight—it gave me the foundation to finally have a healthy relationship with food. I still enjoy eating. But now I understand that the daily habits are what separate fat gain from muscle gain. So—where are you at? 👇
Poll
224 members have voted
Quick poll: Where are you at in your research journey?
0 likes • 5h
I am closing in on switching to maintenance. I'm about 20 +/- pounds away from my goal weight. I have health conditions (gotta love your gene pool) that I am trying to make better and keep from escalating along with weight loss so it's a multi answer for me. My doctor labels me "healthy" yet the list of things I monitor and am mindful of is, to me, insane. They started hitting one by one in rapid succession in my mid to late 40s. A lot is hereditary. I still feel basically good, better than I did 12 yrs ago so there's that. I benefit from mostly all of your content. THANK YOU SO MUCH!!!
Syringe Gauges Explained: Why Your Insulin Syringe Won't Work for Everything 💉
For research use only. Not for human consumption. If you've ever tried to draw up L-carnitine or B12 with an insulin syringe and felt like you were trying to suck a milkshake through a coffee grinder—this post is for you. I see people get confused all the time. First, Understand This One Thing The gauge number tells you how thick the needle is. But here's what trips everyone up: Higher gauge = thinner needle So a 31 gauge needle is super thin (like an insulin syringe), while an 18 gauge needle is thick (like what they use to draw blood). Think of it like this: the higher the number, the smaller the hole. Why Insulin Syringes Work Great for Peptides Insulin syringes come with tiny 29-31 gauge needles built in. They're perfect for reconstituted peptides because when you mix a peptide with bacteriostatic water, you get a thin, water-like solution. Thin solution + thin needle = no problem. Why Insulin Syringes Fail with L-Carnitine and B12 These solutions are thicker. They're not mixed with just water—they often have different carriers that make them more viscous. Now you're trying to pull a thick solution through a tiny opening. What happens: You pull back on the plunger and barely anything moves. You're fighting the syringe the whole time. Air bubbles form because of all that resistance. What should take 5 seconds takes over a minute. You might even bend the needle from all that pressure. It's frustrating and unnecessary. The Fix: Draw with a Bigger Needle, Swap for Administration Here's the move that makes life easier: Step 1: Get syringes with removable needles (called luer lock syringes) Step 2: Attach a 22 or 23 gauge needle to draw up your solution. This is a wider opening, so thick solutions pull through easily. Step 3: Once you've drawn what you need, twist off that needle and swap it for a 27-30 gauge needle for administration. Smaller needle = more comfortable. That's it. Draw big, administer small. What Gauge for What? Reconstituted peptides (mixed with bac water): Insulin syringes work perfectly. No need to swap anything. The 29-31 gauge handles it fine.
Syringe Gauges Explained: Why Your Insulin Syringe Won't Work for Everything 💉
0 likes • 5h
@Danielle Ward I'm not adding more supplies unless I absolutely have to. I'm just stubborn like that. Lol. I'll deal with the longer time it takes to draw it up.
0 likes • 5h
@Derek Pruski I tried a blend from a vendor I used to use a while back not from price tool and tbh it didn't do much for me. Several people all raved about how when they hit a weight loss plateau it broke through the plateau & they started losing again. I did not experience any more weight loss, my energy didn't feel like it had increased and neither did my endurance. I think my body just processes certain things differently. That's all I can come up with because Mots-C and 5 Amino didn't give me anything great either. Yet somehow NAD & Glutathione sets my energy off the charts.
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Lisa G
6
1,116points to level up
@lisa-goike-7692
Just a woman of a certain age trying to maintain...

Active 22m ago
Joined Aug 23, 2025
Detroit