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15d • Peptide Tips
Syringe Gauges Explained: Why Your Insulin Syringe Won't Work for Everything đź’‰
For research use only. Not for human consumption.
If you've ever tried to draw up L-carnitine or B12 with an insulin syringe and felt like you were trying to suck a milkshake through a coffee grinder—this post is for you. I see people get confused all the time.
First, Understand This One Thing
The gauge number tells you how thick the needle is. But here's what trips everyone up:
Higher gauge = thinner needle
So a 31 gauge needle is super thin (like an insulin syringe), while an 18 gauge needle is thick (like what they use to draw blood).
Think of it like this: the higher the number, the smaller the hole.
Why Insulin Syringes Work Great for Peptides
Insulin syringes come with tiny 29-31 gauge needles built in. They're perfect for reconstituted peptides because when you mix a peptide with bacteriostatic water, you get a thin, water-like solution.
Thin solution + thin needle = no problem.
Why Insulin Syringes Fail with L-Carnitine and B12
These solutions are thicker. They're not mixed with just water—they often have different carriers that make them more viscous.
Now you're trying to pull a thick solution through a tiny opening.
What happens:
You pull back on the plunger and barely anything moves. You're fighting the syringe the whole time. Air bubbles form because of all that resistance. What should take 5 seconds takes over a minute. You might even bend the needle from all that pressure.
It's frustrating and unnecessary.
The Fix: Draw with a Bigger Needle, Swap for Administration
Here's the move that makes life easier:
Step 1: Get syringes with removable needles (called luer lock syringes)
Step 2: Attach a 22 or 23 gauge needle to draw up your solution. This is a wider opening, so thick solutions pull through easily.
Step 3: Once you've drawn what you need, twist off that needle and swap it for a 27-30 gauge needle for administration. Smaller needle = more comfortable.
That's it. Draw big, administer small.
What Gauge for What?
Reconstituted peptides (mixed with bac water): Insulin syringes work perfectly. No need to swap anything. The 29-31 gauge handles it fine.
L-Carnitine: Draw with 22-23 gauge, administer with 25-27 gauge.
B12 (the thick stuff): Draw with 22-23 gauge, administer with 25-27 gauge.
Oil-based solutions: Draw with 18-20 gauge (these are really thick), administer with 23-25 gauge.
The Bottom Line
Insulin syringes are amazing for peptide research. But the moment you branch into thicker solutions, you need luer lock syringes and a few different needle sizes.
Once you do this once, you'll never go back to fighting an insulin syringe for L-carnitine again.
Questions? Drop them below 👇
This information is provided for educational and research purposes only.
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Syringe Gauges Explained: Why Your Insulin Syringe Won't Work for Everything đź’‰
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