Retatrutide - Don't Get FOMO · Hacksmith's Free Peptalk Group

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Retatrutide - Don't Get FOMO

Yesterday I asked a couple of questions about what people think the benefits of Retatrutide are that other GLPs don't give, as well as the specific benefits of the glucagon receptor component. Let's address those below, so you don't feel like you have FOMO if you don't use it instead of other GLPs.

Disclaimer: I've used Reta for over 18 months. I love it.

The glucagon fat-burning benefit - Glucagon agonism can cause hepatic lipolysis (liver breaking down fat) and increasing energy expenditure. But guess what? Tirzepatide also reduces visceral fat significantly. Retatrutide doesn't reduce it but by maybe 8-10% more than Tirzepatide does. And the "fat-burning benefit" likely ends up being a maximum of 100-200 calories/day that it burns and is really going to exist at the higher dose. So "microdosing Reta with Tirz for fat-burning" likely isn't doing much for you.

2. Reduces / reverses fatty liver - Retatrutide is about 86% reduction of NAFLD, but Tirzepatide was somewhere around 60%. So yes, Retatrutide is really the best one on the market for this, but it isn't so significant that you have to use it over something like Tirzepatide in order to get this benefit.

3. Retatrutide prevents muscle loss / is muscle building - If you look at the DEXA data for Reta, about 80% of the weight loss is fat mass. But guess what? Tirz is about the same generally speaking. Now, Reta typically gives you less of a "feeling" of strong suppression, which lets you keep calories high, which means that protein is higher, which means that you can preserve more muscle. But ultimately, if you use a low enough dose of any GLP to where your appetite isn't completely crushed, then you'll be able to mitigate muscle loss.

4. Insulin resistance - Retatrutide definitely helps with insulin resistance. But the A1C reduction isn't quite as good as Tirzepatide's. So while it can be a great solution to fight against something like diabetes, it's likely not going to do it for you the way that Tirzepatide will.

5. Improves cholesterol and triglycerides - This is definitely a true benefit of Retatrutide, but like the previous points, you have significant benefit to these markers with Tirzepatide too.

6. Reducing inflammation - Retatrutide reduces inflammation for sure. Some don't feel it's as much as Tirz does based on their anecdotal experiences though. But guess what also reduces inflammation? Weight loss. So this is something you'll likely experience as weight and visceral fat decreases anyways.

7. Cleaner appetite suppression - Now this one shines to me as one of the biggest standout benefits of Retatrutide. Generally speaking, Retatrutide doesn't make you feel like you absolutely can't eat. But it still gives some appetite control. However, if you're someone who really struggles with food noise, Tirzepatide may be the thing that feels most comfortable for you personally.

8. Decreased blood pressure - Again, this will likely happen with any weight loss intervention.

So, as you can see, most of the benefits of Retatrutide can be achieved with other compounds!

When should you choose Retatrutide?

If you've never used a GLP-1.
If your current GLP-1 is always too suppressive and you feel like you can't eat and are low energy, even at lower dosages.
Food noise isn't your number 1 concern.
You want to be able to generally eat and enjoy foods without feeling so full all of the time.

Hopefully this helps weed through some of the FOMO.

Like I said, I love Reta, but SO MANY people are frustrated and stuck because they didn't want to miss out on the "benefits" that they're basically already getting. So they put themselves 5 steps backwards for nothing.

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