In 2021 I was diagnosed with osteoarthritis in my left knee. At age 53 the advice was, keep training to sustain muscle mass and thereby support the knee as much as possible. Further advice was not to operate. A large portion of the cartilage was already gone by then and no magic supplement was going to bring it back. It was all about buying time. Fast forward, the recent diagnoses shows all cartilage on the inner part of the knee is gone. That was to be expected. Slowly over the years I started limping more, difficulty getting up the stairs, having frequent lower back issues and for the past 3 months daily interrupted sleep because of pain. The orthopedic surgeon gave me two options, cortisone injections or a knee joint replacement which he doesn’t favor because at 58 I’m still in the “young” category. Since cortisone injections are not a sustainable long term solution I’m considering a replacement. I’m pretty much done with the pain and limp. My question is, what is a good strategy to prepare my body for surgery (before and after) to enhance the recovery process, using peptides (or other) and localized red light therapy? Any input from the community is highly appreciated.

L-carnitine is something I have used and been looking into deeper. It certainly is pushed and sold as something great. Is there direct evidence or mostly mechanistically inferred? For this conversation, let’s assume it’s injectable not oral, something like 5-600mg. As I look into how it works, it really seems like carnitine is more of a recycle system. I won’t go all into it here but generally if I am eating right, I should have all I need. I wonder if Anthony would consider it more the way he talks about NAD+ (in relationship to taking it or not taking it). It might help, it might do nothing, it might hurt. I’m curious what @Anthony Castore has to say, but certainly anyone else as well.

Anyone here have experience with SLU-PP-332 vs SLU-PP-915? The dosing range I keep seeing for 332 is confusing. Some people report noticeable benefits around 500 mcg, while others talk about using hundreds of milligrams (even 400 mg like the kid on DDT). That’s an enormous difference. Now SLU-PP-915 is showing up and is supposedly more potent/effective, which makes the dosing question even more confusing. For anyone who’s researched with these: why is there such a massive range with 332, and how does 915 actually compare in terms of potency and expected effects?

Does anyone have experience with SLUPP as an injectable? We have a patient injecting a solution of 2ml bac water .5ml of DSMO and 5mg of the SLUPP powder. I am having a hard time finding it in the injectable form through our 503A pharmacy's. Is there a big difference between it and the pill form other than the obvious?

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