Tesamorelin Storage Study Update: We're Running It 🔥
A lot of you have been following the debate about whether research-grade tesamorelin should be refrigerated or stored at room temperature after reconstitution. For those just catching up: most peptides go in the fridge after you mix them. But tesamorelin might be an exception. The FDA-approved version (EGRIFTA WR) specifically says room temperature storage. Josh Holyfield, a creator in this space, argues that research-grade tesamorelin follows the same rules because the molecule itself has properties that cause it to clump together when cold. His position is that standard purity testing won't even catch this because the issue is physical aggregation — molecules binding to each other — not chemical breakdown of the amino acid chain. Fair argument. But I'd rather have data than debate. So I called Kris at Freedom Diagnostics. We're doing the study. Here's the plan: we're taking reconstituted tesamorelin and splitting it into two samples. One stored at room temperature, one refrigerated. Then we test both over time. I also asked Kris to get input from other chemists on the theory that cold temperatures cause the amino acids to aggregate and make tesamorelin ineffective. His initial take was interesting — if physical aggregation is happening, we should see a measurable difference in overall mass over time and likely some shift in purity as well. That's not a final answer. That's a starting point. We'll let the results speak. What I want you to take away from this: This community has always been about transparency. I'm not a chemist. I'm not going to pretend I know more than people who study this for a living. What I can is get the testing done, and bring you the results. If the data shows refrigeration is a problem, I'll say so. If it shows room temp is better, I'll say that too. If it's somewhere in the middle, you'll see that as well. I'm also hoping to get Kris on a Podcast after the study wraps so we can walk through the findings together and answer your questions live.