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I've been getting a lot of questions about MOTS-C and weight training lately. I've touched on this before, but let's break down the practical application so you can get the most out of your research. Note: This information is for research purposes only and is not intended as medical advice or guidance for human consumption. The Short Version Don't administer MOTS-C right before resistance training if the research goal involves building or retaining muscle tissue. Here's what the timing should look like instead: - A (Morning Training Protocol): Train → Post-workout meal → MOTS-C administration later in the day - Option B (Most Optimal Protocol): MOTS-C first thing AM → Fasted cardio → Resistance training in the afternoon Why Timing Matters: The Science Made Simple MOTS-C is an incredible energy and metabolic peptide, but it works through pathways that can interfere with muscle growth if timing isn't dialed in. Let me walk you through the mechanisms. 1. AMPK Activation (The Energy Switch) MOTS-C is a potent activator of something called AMPK. Think of AMPK as the body's "energy conservation mode." When AMPK is activated, the body prioritizes: - Burning fuel for energy - Breaking things down (catabolic processes) - Improving metabolic efficiency What gets deprioritized: - Building new tissue - Protein synthesis - Growth processes The problem: Muscle growth requires the opposite state. You want mTOR activated (the "building mode" switch), not AMPK. These two pathways essentially oppose each other. When one is on, the other is suppressed. In plain English: MOTS-C tells the body "let's be efficient with energy," while muscle building requires the body to say "let's invest energy into growth." Both can't fully happen at the same time. 2. Protein Synthesis Interference After resistance training, muscles have a window where they're primed to absorb nutrients and build new tissue. This is when protein synthesis rates are elevated. MOTS-C's AMPK activation can directly blunt this protein synthesis response. If MOTS-C is circulating during that critical post-workout window, it essentially puts the brakes on the very process that training just triggered.

Has anyone had this issue before I reconstituted this last night and it’s still not mixing. Google says it could’ve been cause the Bac water was too cold but I’m not too sure

I’ve been experimenting with my rat with tesamorelin. At the beginning of the cut I started around 175 pounds. After 3 weeks of cutting and tesa I still fluctuate around 175 pounds. I know I’m in a deficit and also on Reta so confused about the no change in scale weight. Although the weight is the same I am looking leaner in the mirror. Just wondering if anyone else has experienced things like this while experimenting with tesa

If your sleep has been trash since starting GH secretagogues (ipamorelin, CJC, MK-677, etc.), you're not crazy - this is a real thing that happens to some people. Even pharmaceutical GH causes sleep issues for certain individuals. Full sleep stack including peptides coming soon, drop a 🔥 if you're ready to see it. Research + Educational Purposes Only, Not Medical Advice. The frustrating part? You're taking these peptides to improve recovery and body composition, but poor sleep absolutely tanks those benefits. So let's fix it. Why Does This Happen? GH secretagogues tell your body to release more growth hormone. Normally, GH gets released during deep sleep. But when you artificially stimulate it (especially in the evening), it can mess with your natural sleep cycles. Think of it like drinking coffee - caffeine isn't bad, but if you drink it at 9 PM, you're probably not sleeping well. Timing matters. Start Here: Fix These Lifestyle Basics First Before you change your dosing protocol, try these strategies. For most people, one or two of these fixes will solve the problem completely. Stop Eating So Close to Bedtime The rule: Last meal should be 3-5 hours before bed. Here's why this matters so much: Your stomach takes 2-4 hours to empty a normal meal. If you're on a GLP-1 (semaglutide, tirzepatide, retatrutide), that time doubles or triples - we're talking 4-6+ hours. When you lie down with food still in your stomach: - You get reflux and discomfort - Your body is busy digesting instead of recovering - GH release is blunted (you want to be in a fasted state) - You just feel... off What to do: - Eat your last meal 3 hours before bed minimum - If you're on a GLP-1 or had a big meal, make it 5 hours - Keep dinner lighter - focus on protein and veggies, go easy on heavy carbs and fats Stop Chugging Water Before Bed If you're waking up to pee 2-3 times a night, you're destroying your sleep quality. Every time you get up, you're interrupting your deep sleep cycles.