In the latest DDT Method podcast with @Anthony Castore , Anthony discussed NAD supplementation. What I found interesting is that Anthony seemed to be against NAD supplementation via NAD+ and its precursors if I understood correctly, and a more appropriate approach would be to instead use a combination of 5 amino and 1MNA. He suggested using 5 amino pre workout and 1MNA on rest days in the evening. Anthony - would you be able to expand on your thoughts regarding NAD supplementation given it seems like a given in the longevity community that you supplement with NAD+ (injection or IV) or its precursors (NMN, NR).

Anthony and friends - Dose anyone have any protocols in how to reduce/improve Lipoprotein(a)? - Dose any Peptides have risks factors? Thanks!

Over the past few years, I’ve been using GH fairly regularly. I have access to high-quality pharmaceutical-grade GH, so I didn’t overthink it. At my age (54), the difference in how I feel, recover, and sleep is definitely noticeable. That’s always been the main reason I’ve used it, and 2 - 3 IU per day was enough for me. I only increased the dose before a competition to enhance fat burning. However, after listening to and reading content from Antony and Dr. Seeds, I came to understand that constant activation of mTOR and supraphysiological levels of IGF might improve well-being and appearance as we age — but they can also accelerate aging. That said, I used GH mostly while on a ketogenic diet, where GH doesn’t significantly elevate IGF, so that likely minimized the effect. Now I’ve been off GH for two months, and I’d like to test a protocol using GHRH and GHRP, aiming for more pulsatile GH release, and therefore potentially fewer negative effects on long-term health. I have access to the following peptides: Ipamorelin Sermorelin Fragment 176–191 IGF-1 DES MK-677 PEG-MGF MOD-GRF 1-29 CJC-1295 + DAC IGF-1 LR3 What would be the best combinations for: 1. Long-term health 2. Optimal anabolism 3. Fat loss pre-competition Thanks!

Let me tell you a story about the most important muscle in your body that almost nobody trains, almost nobody understands, and almost everybody is slowly losing. The diaphragm is not just a breathing muscle. That description is like calling the brain a “thinking organ.” It’s technically true, but it misses the point so badly that it becomes misleading. The diaphragm is a living interface between structure and signal, between chemistry and physics, between voluntary and involuntary control. It is a biological transistor. A gatekeeper. A conductor that coordinates pressure, charge, rhythm, and information across the entire organism. If you understand the diaphragm, you understand how the body integrates itself. If you lose the diaphragm, the body fragments. Let’s start simply, then go deep very deep. At the most basic level, the diaphragm is a dome-shaped sheet of muscle that separates the thoracic cavity from the abdominal cavity. When it contracts, it descends. When it relaxes, it recoils upward. This movement changes pressure in the chest and abdomen and drives airflow in and out of the lungs. That’s the textbook version. It’s also the least interesting. The diaphragm is the only skeletal muscle in the body that is both voluntary and involuntary. You can control it, but it doesn’t need you. That alone should make you suspicious that it sits at a crossroads no other muscle occupies. Embedded in and passing through the diaphragm are some of the most important structures in the body: the inferior vena cava, the esophagus, the aorta, lymphatic channels, and dense autonomic nerve plexuses. Every breath mechanically massages blood, lymph, and nerves. This is not a side effect. This is the design. Each diaphragmatic contraction creates a pressure wave. That wave propagates through fluid-filled tissues, fascia, and organs. Pressure waves in biological tissue are not just mechanical events. They are information-bearing phenomena. They alter ion channel behavior, membrane tension, protein conformation, and mitochondrial function.

After a long time, I’ll be in the US again as I’m heading to the Olympia. I also got a ticket for Olympia University, and I see that at least two members of the group will be speaking there – @Elizabeth Yurth and @Eric Fete. Can’t wait :) Will anyone else be there?