6d • General Discussion
Clinical Trial Alert: New Vagus Nerve Stimulation Study For Depression
Clinical trial alert: Non-invasive ultrasonic auricular vagus nerve stimulation (uaVNS) is under investigation.
Launched December 16, 2025, the trial employs low-intensity focused ultrasound (LIFU) via a wearable ear device.
LIFU targets the auricular branch of the vagus nerve. Acoustic pressure waves mechanically activate voltage-gated ion channels.
This promotes afferent signaling to brainstem nuclei, enhancing parasympathetic outflow. Inflammation is modulated via the cholinergic anti-inflammatory pathway.
Compared to transcutaneous electrical VNS (taVNS), uaVNS offers superior penetration and spatial precision. No skin irritation.
The double-blind, randomized, sham-controlled study includes 80 adults with major depressive disorder.
Protocol: 30-min daily sessions for 12 weeks. Primary endpoint: MADRS reduction. Secondary: HRV, cytokine levels, fMRI.
Preclinical rodent models show uaVNS yields a 25% greater HRV increase. Locus coeruleus norepinephrine modulation is 40% more robust than taVNS.
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Clinical Trial Alert: New Vagus Nerve Stimulation Study For Depression
skool.com/vagus
This group is designed for the discussion of the Vagus Nerve, techniques to stimulate it, and the benefits of doing so.
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