Is It Better to Pulse on Consecutive Days or with Gaps in Between?

I recently reached out to Dr. Dominic D’Agostino with a question many of us have asked:

Is it more effective to pulse oxidative or cytotoxic therapies on consecutive days (e.g., Mon–Wed) or spaced out (e.g., Mon/Wed/Fri)?

Here’s what he shared:

“This depends on the type of pulse therapy, cancer type, standard of care, individual response, specific biomarkers, etc. There is little data and it is hard to speculate. We did M/W/F for HBOT in mice for a variety of reasons discussed in our publications. My approach would be to apply other pulse therapies in a way that causes minimal or no side effects. Dosage can be adjusted and individualized as response is observed.”

— Dr. Dominic D’Agostino

Takeaway:

There’s no one-size-fits-all answer. The best pulsing schedule is likely the one that:

Causes minimal or no side effects
Fits within the patient’s overall metabolic protocol
Can be adjusted based on response and biomarkers

For example, in a mouse study using a ketogenic diet + HBOT (hyperbaric oxygen therapy), they used a Monday/Wednesday/Friday schedule. This might offer a model worth considering — not because it’s universally best, but because it’s been shown to improve survival in that specific context.

As always, keep in mind:

The cancer type and progression matter
Therapies like IV vitamin C have short half-lives (2–3 hours), so timing may influence effectiveness
Cancer cells can adapt — so switching things up periodically might help

If you’re pulsing therapies in your own or a loved one’s protocol, consider tracking biomarkers, symptoms, and energy levels. Personalization and flexibility are key.

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