Cancer progression, a Failure of Immune Surveillance

In a healthy host, abnormal cells are detected and eliminated by natural killer cells, cytotoxic CD8+ T cells, dendritic cells, macrophages, and coordinated cytokine signaling.

In cancer, this system is progressively disabled.

Tumors recruit suppressive immune cells, exhaust T cells, polarize macrophages toward a tumor-supportive phenotype, stimulate angiogenesis, and create a metabolically hostile microenvironment rich in lactate, hypoxia, inflammatory cytokines, and oxidative stress.

The goal of adjunctive repurposed drugs and nutraceuticals is therefore not merely to “kill cancer cells,” but to help restore the host terrain: improve systemic immunity, reduce immune suppression, normalize inflammatory signaling, and make the tumor microenvironment more visible and vulnerable to immune attack.

By Dr. Paul Marik

What are the repurposed drugs and nutraceuticals?, read more here, hope it's helpful:

https://open.substack.com/pub/paulmarik/p/repurposed-drugs-and-nutraceuticals-a25?utm_source=share&utm_medium=android&r=583u8k

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Cancer progression, a Failure of Immune Surveillance