Yesterday I asked a couple of questions about what people think the benefits of Retatrutide are that other GLPs don't give, as well as the specific benefits of the glucagon receptor component. Let's address those below, so you don't feel like you have FOMO if you don't use it instead of other GLPs. Disclaimer: I've used Reta for over 18 months. I love it. 1. The glucagon fat-burning benefit - Glucagon agonism can cause hepatic lipolysis (liver breaking down fat) and increasing energy expenditure. But guess what? Tirzepatide also reduces visceral fat significantly. Retatrutide doesn't reduce it but by maybe 8-10% more than Tirzepatide does. And the "fat-burning benefit" likely ends up being a maximum of 100-200 calories/day that it burns and is really going to exist at the higher dose. So "microdosing Reta with Tirz for fat-burning" likely isn't doing much for you. 2. Reduces / reverses fatty liver - Retatrutide is about 86% reduction of NAFLD, but Tirzepatide was somewhere around 60%. So yes, Retatrutide is really the best one on the market for this, but it isn't so significant that you have to use it over something like Tirzepatide in order to get this benefit. 3. Retatrutide prevents muscle loss / is muscle building - If you look at the DEXA data for Reta, about 80% of the weight loss is fat mass. But guess what? Tirz is about the same generally speaking. Now, Reta typically gives you less of a "feeling" of strong suppression, which lets you keep calories high, which means that protein is higher, which means that you can preserve more muscle. But ultimately, if you use a low enough dose of any GLP to where your appetite isn't completely crushed, then you'll be able to mitigate muscle loss. 4. Insulin resistance - Retatrutide definitely helps with insulin resistance. But the A1C reduction isn't quite as good as Tirzepatide's. So while it can be a great solution to fight against something like diabetes, it's likely not going to do it for you the way that Tirzepatide will.