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7 contributions to Castore: Built to Adapt
Sep 23 •
Dependence from Adderall, dopamine question
Hi All, Have a friend who tried to go cold turkey from A 15 year dependence on adderall. I’ve had him focused on his diet, exercise and day to day habits. Since removing adderall, he is experiencing differing levels of anxiety (heart palpitations, racing thoughts, etc). My thoughts are his dopamine receptors and levels are shot. Any thoughts on peptides that could help reset? Anyone else know of anyone like this and approaches others took? Thanks, Nate
0 likes • Oct 9
Sabroxy and 9-me-bc are really helpful for those coming up stims like addy or modafinil. In particular, we have had a decent amount of success stories with the our 9-me-bc transdermal being used on the back of your neck to help assist better blood brain barrier permeability. 9-me is lipophillic in nature so it doesn’t have too much difficulty doing so. This can help to dopamine reuptake and regulation. As someone who has leveraged Adderall before in university, I can personally attest to how horrendous a dopamine crash can be. Stopping cold turkey is about the worst possible decision you can make
Aug 11 •
Adamax
Has anyone taken this? Have any info? I want to start it from what I have researched, but definitely pretty limited info. Thanks!
1 like • Aug 13
@Anaa Jones if I could take a guess it’s because generally speaking, the effects are more acute and immediate when you use an atomizer therefore it’s a little more noticeable and easier to make comparisons in my experience. If you do something subcutaneously, the onset, peak and duration are a little slower and less pronounced. As a diabetic, I would use the analogy of fast acting insulin versus intermediate acting insulin to try to draw a comparison.
1 like • Aug 13
@Anaa Jones I usually try to take mental notes of onset, peak, and duration. Obviously, all of that looks different with every compound and the method of administration as well. I personally compound all of our transdermal‘s, so that is very important in dosing those correctly for example.
Jul 1 •
vendor ?
Just wanted to get feedback on a vendor. Research 1 peptides. Anyone order from them and have any feedback? The prices are just so much less than others. Like 50% less
2 likes • Aug 12
Don’t forget if it’s too good to be true it usually is. You get what you pay for to a degree.
Aug 12 •
BPH (benign prostatic hyperplasia) recommendations
Any recommendations for BPH to avoid surgery? Peptides, supplements, lifestyles interventions etc? My father is 63 and can not effectively urinate without a catheter. Doctors are telling him that surgery is the only solution. Like most he doesn't want to have surgery and is asking me for other potential alternatives. Any help would be appreciated. Thanks
2 likes • Aug 12
I started with low dose Cialis. Flomax does work well for some people, but can also cause retrograde ejaculation. There are also some things you can do to try to shrink it, but the side effects aren’t worth it in my opinion. Mirabegron is also helpful and the mechanism of action works on your bladder.. avoid excessive caffeine, spicy foods, and too many liquids before bed. All of that does make a big difference.
Jun 11 •
SGLT2 and Trehalose
Hello everyone! There’s been much talk about SGLT2 inhibitors and its benefits in terms of longevity and overall optimization. I’m really interested in trying it. Has anyone tried it and what are your experiences? My concern in my situation is that I don’t eat a lot of carbs and my fasting insulin is already low, below 3. Wouldn’t that give me the risk of having eu glycemic keto acidosis? Any insights? About Trehalose, I read Anthony recommending taking it fasted for autophagy. Great. However, taking it fasted wouldn’t it break the fast since it’s an actual sugar? And for the autophagy activating benefits what dose should be taken at once?
0 likes • Jun 12
@Diva Osorio there is one caution you must take with this type of diabetic medication as a female because you’ll be much more prone to UTI since you are urinating out an excess of sugar due to the mechanism of action of the drug. Unfortunately, some are able to use it, and some are not. On paper this compound is fantastic, but even as a male, the excessive urination is unbearable.
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@keith-greiner-4040
I love Peptides and I’m looking forward to learning more from Alex and by joining this group.
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Joined Dec 7, 2025
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