@Anaa Jones Hi Anaa, thanks for reaching out. I actually had a vile given to me by my peptide rep. I have done as much research as I can find and it looks good I. Haven't reconstituted it yet or used it. I just got it yesterday.

@Natalie Layton 1. Don't inject in your stomach. Do your thigh area. 2, add another ml of BAC water. 3, let the mots get room temp before injecting. These 3 things can help drastically.

@AngeCN W no, not a problem at all. Your skin tissue is full of immune cells called mast cells. And mast cells exist to respond when a foreign substance enters your tissue. They're packed with a chemical called histamine, and when they detect something that shouldn't be there, they release that histamine into the surrounding area. And histamine is what triggers the inflammation. It opens up your blood vessels, increases blood flow, and sends immune resources to the site. So the redness, the swelling, the heat, the burning you feel after your injection, that's all histamine doing exactly what it's designed to do. Now here's where peptides come in. GHK and MOTS-c both carry a positive electrical charge, which makes them cationic peptides. And research has shown that cationic peptides trigger mast cells to open up and dump their histamine directly into the surrounding tissue. This is called degranulation. And unlike a true allergic reaction where your immune system has to recognize something as a threat and build a targeted response over repeated exposures, this is purely chemical. The positive charge on the peptide interacts directly with the mast cell, and that interaction is what causes the release. And the reaction is concentration dependent. The more peptide that hits one small area of tissue at the same time, the more mast cells fire, and the bigger the reaction. So now that you understand why it's happening, let me show you how to fix it. You can dilute your solution with extra bacteriostatic water so there's less peptide per unit of volume. You can inject slowly so you're not delivering a concentrated hit to one cluster of mast cells all at once. You can warm the solution to room temperature so it disperses through the tissue more evenly. And you can take an antihistamine about 30 minutes before your injection to block the histamine receptors downstream. Now one thing I do want you to keep in mind. Everything I just described is a local reaction, and if it stays around the injection site and goes away within a few hours, that is completely normal with these peptides.

I have a reconstituted bottle (DMSO). Would like more info before trying myself.