"Tirzepatide preserves muscle during weight loss." "GIP agonism protects lean mass." "Unlike semaglutide, retatrutide maintains muscle." I see this everywhere. Vendors say it. Influencers repeat it. Even some research papers imply it. Here's the problem: it's not true. Tirzepatide and retatrutide don't preserve muscle. They just lose less of it than semaglutide. And that distinction matters way more than you think. The mechanisms are real: - GIP improves nutrient partitioning - Glucagon ramps up fat oxidation - Both shift the fat-to-muscle ratio in your favor But here's what nobody tells you: you're still at serious risk for muscle loss if you're not prioritizing protein and training. The dual and triple agonists give you better odds. They create a more favorable metabolic environment. But they don't do the work for you. People hear "muscle preservation" and think they can skip protein targets. They think the peptide handles it. Then they lose 60 pounds and wonder why they look soft and feel weak. I broke down: - What GIP and glucagon actually do (vs what marketing claims) - Why the TRIUMPH-4 data doesn't show what people think it shows - The real hierarchy of what preserves muscle (hint: compound choice is #5) - When tirzepatide/retatrutide actually make a meaningful difference - How to optimize regardless of which compound you choose Read the full article here: https://open.substack.com/pub/derekpruski/p/tirzepatide-and-retatrutide-dont?r=4jq1x8&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Drop your thoughts below. Have you been prioritizing the compound over the fundamentals? RESEARCH USE ONLY. Not Medical Advice!

Hey everyone! I just rolled out a feature that I think is going to make your life a LOT easier when shopping these sales. 🔍 How It Works You'll now see an orange percentage indicator next to prices on PeptidePrice.store. Click it, and you'll get a complete breakdown of exactly how the math works on stacked discounts. 📊 Real Example Check out this AOD-9604 listing from AMP Peptides: - Original Price: $35.00 - Holiday Sale (-10%): $35.00 × 0.90 = $31.50 (saves $3.50) - Code derek15 (-15%): $31.50 × 0.85 = $26.77 (saves $4.73) - Final Price: $26.77 - Total Savings: $8.23 (24% off!) The breakdown shows you step-by-step how each discount applies and compounds, so there's no more guessing about whether codes stack or if you're just getting the sitewide sale. 💡 Why This Matters I know there's been confusion about: - "Does my code stack with the sale?" - "Am I getting the best deal?" - "How did they calculate this?" Now it's 100% transparent. If discounts are stackable, you'll see the ⚡ indicator and the full math. If it's just a sitewide sale, you'll see that too. Demo video: https://vimeo.com/1145957694?share=copy&fl=sv&fe=ci Try it yourself: https://peptideprice.store Let me know what you think! Any feedback is welcome 🙏

Hey everyone - there's been some stuff I've been dying to fix. The whole reason PeptidePrice exists is because I wanted to build THE all-in-one tool that makes it stupid easy for every researcher to make informed decisions. You're about to see some big changes coming: 1. Stackable Discounts (finally fixing this) I've seen the confusion with Valor's sale and Peptira's pricing before - their sites auto-markdown prices (like $100 → $80), then your coupon code applies on top (80 → $72). Right now that's not super clear on my site. Don't worry, I have a fix for this and it's coming soon... 2. No More "Ghost" Sales I'm actively staying on top of retailers now. Not launching ANY sales or products on the site until I personally verify they're live and functional. Too many times I've had owners say "hey this is live" → I check and it's out of stock or coupons don't work. Not a good look for me, so even if sales are delayed a bit, I want the best experience for you all. 3. Price Tracking is LIVE (retailers, I see you 👀) The backend price tracking tool is running. If I catch a price hike right before these sales, I'm calling it out and advertising based on what prices were just days ago. So far since Black Friday, it's been solid. PSA to all retailers: 30% off isn't 30% off when you hike prices up 20% first. Not acceptable. Run your business how you want, but I'm gonna keep it real. 4. Shipping Updates Shipping costs and policies have been changing like crazy. I haven't been keeping it 100% up to date - that's changing NOW. Adding this to my daily updates with some advanced features to make it more visible on the site. 5. Content Strategy Shift Content will still come out, but I'm trying to be more impactful with every post. This might mean less overall volume, but I want to break down the full picture so you can make informed decisions as researchers. Quality over quantity. 6. 2026... 👀 I'll keep the bonus features quiet for now, but you're not ready for what's coming. PeptidePrice will continue to level up. We don't stop.

Alright, so Lilly dropped their TRIUMPH-4 Phase 3 data yesterday for retatrutide. 28.7% weight loss. 71 pounds average. At 68 weeks. If you've been paying attention to triple agonists, this shouldn't be surprising. The Phase 2 data already showed us where this was headed. But now we have the Phase 3 confirmation. Here's what happened: 445 people with obesity and knee osteoarthritis. Split into three groups - 9mg retatrutide, 12mg retatrutide, and placebo. The 12mg group lost an average of 71.2 pounds. That's 28.7% of their starting weight. Compare that to tirzepatide's ~21% in Phase 3. That's 8 percentage points higher. The glucagon agonism makes the difference - you're not just suppressing appetite, you're ramping up energy expenditure and fat oxidation. Why triple agonists hit different: Retatrutide is GIP + GLP-1 + Glucagon. You already know GLP-1 from semaglutide. You know the dual combo from tirzepatide. The glucagon piece is what pushes this into a different category. - GLP-1 = appetite control - GIP = metabolic optimization - Glucagon = fat-burning accelerator You're hitting all three mechanisms simultaneously. The inflammation piece is wild: This trial was designed for knee osteoarthritis, not just weight loss. The pain results were massive: - 76% reduction in pain scores - 74% improvement in physical function - 12% of people completely pain-free by week 68 But here's what's interesting - this wasn't just about losing weight and reducing load on the joints. Retatrutide crushed inflammatory markers across the board. hsCRP dropped significantly. Triglycerides down. Blood pressure down 14 mmHg. Each component has anti-inflammatory effects. GLP-1 reduces pro-inflammatory cytokines. GIP has protective effects on bone and cartilage. Glucagon ramps up fat burning, and less adipose tissue means less inflammatory signaling. You're not just taking pressure off the knee - you're turning down systemic inflammation that's driving the pain in the first place.

As I've been doing stock updates, I've been paying close attention to SS-31 this last week. About 50% of the vendors have removed the product from their sites completely. A couple have been renamed to MTP-331 but, I do see this slowly disappearing. For most of these vendors, the juice isn't worth the squeeze to try and fight a C&D letter for something not as popular as a GLP. I'll keep the site updated. We have about 8 vendors left carrying it. Compare Here -> peptideprice.store