The norepinephrine angle (or any focus on adrenal hormones) is very interesting to me. This is because Pantothenic Acid (B5) is a cofactor in both adrenal hormone creation and conversion of Phosphatidylcholine(PC) (dietary) to acetyl-choline. I recall the ratio being 3000mg PC to 250mg Calcium Pantothenate back in the my college studying days. So in addition to this stimulation I would encourage folks to co-experiment with Pantothenic Acid or Pantetheine supplementation. The difference in drive during intense exercise is quite striking if there is a deficiency. Sometimes deficiency manifests as postural hypotension.

Experimenting around a bit more I do seem to occasionally be going through something where old injuries get heated up. The interesting thing is it usually resolving 24-48 hr later when it was quite painful. So like do the work, 12-24 hours later ouch! Have I hurt myself? Can't move my neck. Low back is 'out' etc. The 1-3 days of hobbling around but then sleep for a bit extra and then whoa! Some kind of pop or crack and all pain is pretty much gone. This is still just using the device on low - so no idea of repeated applications to the pseudo injury spots on medium or high would accelerate the cycle. I have other machines I use from time to time but this is kind of interesting....

Be aware when you supercharge the nervous system of your digestion it may feel fantastic. But it may also be like "Thanks, gonna purge now". LOL #hydrate Enjoy the journey....

Definitely on the list to have when I get my stress clinic going.

@Jennifer Ruziscka Thanks! I will take a look

Hmm. I have a lymphatic tool (called the hemosonic) and the protocol for the abdomen is expanding concentric circles starting at the belly button, spiraling outwards. I'll have to try that once I'm done tickling the spleen.

What about hitting the Solar (celiac) Plexus directly? Seems an easy spot. Non-invasive peripheral focused ultrasound neuromodulation of the celiac plexus ameliorates symptoms in a rat model of inflammatory bowel disease https://pubmed.ncbi.nlm.nih.gov/33512049/#:~:text=According%20to%20a%20study%20published%20in%20*Experimental,marked%20damage%20and%20shortening%20of%20the%20colon

@Sterling Cooley If no one has done it I would suggest filing a provisional use patent on it as a supplement unless you are against such. I'm just thinking even defensively to ensure access not necessarily to be monopolistic about it..

@Sterling Cooley Here is a contrast and compare of companies for scaling up: Potential Pricing (Estimates Based on Similar Custom Products) None publish fixed prices (standard for custom work—all require quotes via form/email/phone). Estimates drawn from their other cyclodextrin/complex services, nutraceutical powder runs, and industry norms for small experimental batches (10–100 g complex + xenon loading): - Advanced Powder Dynamics: Likely the most cost-effective ($2,000–$6,000 for feasibility study + pilot powder batch). Their nutraceutical spray-drying and CyLoc® services are priced for commercial supplements (lab trials to full production); lower overhead than pure CROs. Xenon gas/loading adds ~$500–$1,500. Scale-up is seamless and economical. - Alfa Chemistry: $3,000–$8,000+ for custom α-CD inclusion R&D (their derivative synthesis and complex development services). Competitive for bulk/derivatives but research-oriented fees. Xenon handling extra. - BOC Sciences: $4,000–$10,000+ (larger CDMO with analytical support; flexible R&D-scale supply but pharma rates). Strong value if you want full characterization. - CD Formulation: Similar to BOC ($4,000–$9,000 range) — cost-effective pharma formulation focus but less powder-production optimized. - Common factors affecting price: Xenon gas (~$10–20/L) + inert/high-pressure processing adds cost across all. Minimum orders are flexible (grams for R&D at APD/Alfa/BOC). Expect 4–12 weeks for prototypes. Quotes are free/fast; mention the α-CD xenon paper for accurate scoping. Summary Recommendation - APD first (closest + powder-focused + best value for oral experimentation). Contact: (928) 492-4040 or [email protected]. - Alfa Chemistry if you prioritize pure α-CD chemistry precision. - BOC Sciences for broadest technical options. - CD Formulation is viable but least differentiated here.