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2 contributions to Castore: Built to Adapt
Oct '25 •
NAD Supplementation
In the latest DDT Method podcast with @Anthony Castore , Anthony discussed NAD supplementation. What I found interesting is that Anthony seemed to be against NAD supplementation via NAD+ and its precursors if I understood correctly, and a more appropriate approach would be to instead use a combination of 5 amino and 1MNA. He suggested using 5 amino pre workout and 1MNA on rest days in the evening. Anthony - would you be able to expand on your thoughts regarding NAD supplementation given it seems like a given in the longevity community that you supplement with NAD+ (injection or IV) or its precursors (NMN, NR).
3 likes • Feb 6
@Bob Dubich It's suggested to take TMG along with NAD+ injections so it can replace methyl donors, hoping @Anthony Castore can comment as I'm in the same situation and don't want my NAD+ supply to go to waste. I'm also taking apigenin to reduce CD38.
2 likes • Mar 25
Dr Seeds seems to now prefer NAD+ via subcutaneous injections verse precursors, he speaks about it in this video (please delete if not allowed ) https://fast.wistia.com/embed/channel/iosgc9rgcc?wchannelid=iosgc9rgcc&wmediaid=sv4n2zoi59
Feb 19 •
Anhedonia on GLP-1s
Has anyone found a solution to counteract the side effect of anhedonia besides to come off of it? I've been on Tirzepatide for 5 months. I tried going down in dose but it has not subsided. Has @Anthony Castore ever addressed this?
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