Most research on vitamin D and dementia has looked at people already in their 60s or 70s. A new study from the Framingham Heart Study, published in Neurology Open Access, asked a more consequential question: does your vitamin D level in your 30s and 40s affect your risk of Alzheimer's disease decades later? Among 793 dementia-free adults with an average age of 39, those with higher blood vitamin D levels showed significantly less accumulation of tau on brain scans conducted an average of 16 years later. Tau is a protein that misfolds and builds up in the brain in Alzheimer's disease, and it tends to accumulate in the brain's memory regions well before symptoms appear. The biology behind the link is plausible: the memory centers of the brain are packed with vitamin D receptors, and low vitamin D appears to trigger a chain reaction that accelerates abnormal tau buildup. This adds to an overwhelming body of evidence on vitamin D's importance for long-term brain health and reinforces the value of monitoring your levels before problems emerge. Optimum blood level should be around 70-80.

Creatine is an amazing compound that our bodies make naturally. Long used in the gym for peak muscle performance, a flood of recent research shows that it has profound effects on brain metabolism, cognitive performance under stress (including sleep deprivation), memory, attention, and even mood support. It's also extremely safe to use. Most people need 2-3 grams/day as a baseline - with our bodies making roughly 1g/day from amino acids in the liver, kidneys, and pancreas. According to new studies, boosting creatine intake beyond baseline is extremely good for your brain in everyday healthy adults. One 2024 systematic review and meta-analysis (Frontiers) of 16 randomized controlled trials found that regular creatine supplementation led to improvements in memory and gains in attention and processing speed. These benefits showed up across adults (including healthy individuals). Another review highlighted particularly noticeable memory gains in healthy older adults. And if you're elbow-crawling at work after a night of insomnia, a big dose can have significant effects and kick in fast (within a couple of hours). In one double-blind, randomized study (Nature), participants running on fumes after 21 hours of sleep deprivation experienced a 10.3% boost in word memory performance (plus 17.7% faster processing) and 16–29% gains in processing speed for language, logic, and numeric tasks. A 2024 systematic review and meta-analysis in Frontiers in Nutrition looked at 16 randomized controlled trials involving 492 adults. Creatine supplementation showed positive effects on memory, attention time, and processing speed. A separate 2023 meta-analysis in Nutrition Reviews focused specifically on memory in healthy individuals and found overall improvements, with particularly noticeable gains in older adults.

OTC probiotics can be confusing for some. 🤔 What are the strains that we need to look for and the best amount of live cultures?

If your body is over sensitive, how do you heal it if you can’t even take supplements or adaptagens jeans supplements

A new study published in ACS Omega adds important animal model evidence: researchers administered omeprazole to rats for 10, 30, and 60 days and measured effects on mineral status across blood and multiple organs. Hemoglobin and red blood cell counts declined progressively over the treatment period, while iron accumulated in the liver and spleen even as blood iron levels fell, a pattern consistent with impaired absorption and compensatory redistribution. Hepatic copper concentrations dropped significantly after 30 days, which matters because copper plays a critical role in the pathway through which iron becomes available for hemoglobin synthesis. Calcium redistribution patterns suggested potential bone resorption, consistent with what longer-term human studies have observed. PPIs were only ever approved for short-term use, typically no more than 2 weeks, yet many people take them for years or even decades, often without fully appreciating what that means for their nutritional status. If you're relying on a PPI long-term, speak with your healthcare practitioner about alternatives and a thorough nutritional assessment.