Discontinuous Ketogenic Diet & Cancer Therapy

Jason shared a now-terminated clinical trial exploring a discontinuous ketogenic diet as a metabolic therapy adjunct alongside standard of care (SOC). Despite its closure, he emphasized that the concept still shows promise: alternating between strict keto and strategic reintroduction of carbohydrates may enhance treatment outcomes.

The group reflected deeply on the balance between metabolic flexibility, glucose restriction, and patient sustainability. Some members, like Michael Wright and Joseph Lackland, expressed concern about reintroducing carbs due to cancer’s glucose dependency, while others acknowledged the potential for therapeutic cycling if carefully monitored.

✅ Compounds & Therapies Discussed

● Full Spectrum Cannabis Oil (used by Joseph Lackland)

● Fenbendazole (3x weekly pulsing)

● Hydrogen Therapy (AquaCure AC50): discussed as complementary and possibly synergistic with keto cycles

● Discontinuous Keto Diet:

○ Based on NCT05119010 (terminated), but related studies still ongoing

○ Cycles between ketogenic state and controlled carb refeeding (~100g carbs/day for ~15 days off)

○ Aimed at enhancing immune response and metabolic pressure on tumors

● Strict Ketogenic / Carnivore Diets:

○ Many users reported long-term adherence (1.5+ years)

○ Debate over reintroducing carbs vs. staying ultra-strict

● Hydrogen Therapy:

○ Advocated by Jason Watson as a universal, low-toxicity adjunct

○ Shared links and settings for safe use and troubleshooting (PPM testing, taste changes, avoiding lye

✅ Lab Testing & Metrics

● GKI (Glucose Ketone Index)

○ Targeting GKI <2 for metabolic pressure

○ Concerns raised that even small protein or carb deviations may push glucose up enough to re-feed tumors

● Methionine Sensitivity: Christine Michaud highlighted concern over methionine-rich foods (meat/dairy/nuts) potentially fueling tumor growth (Now debunked by Professor Seyfried)

✅ Resources & References Shared

● Clinical Trial – Discontinuous Ketogenic Diet + SOC (Terminated)

● PMC article on Ketogenic Diet in Oncology (2024)

● Dr Gary Fettke (Randle Cycle & Glucose Toxicity)

✅ Key Takeaways

● Discontinuous keto cycles are emerging as a promising metabolic tool, even if trials are still early or incomplete

● Flexibility vs. Consistency: The community remains divided between unwavering strict keto and structured cycling with metabolic intent● Hydrogen therapy (H₂ gas and water) is gaining traction as an adjunct to all protocols due to safety and versatility

● Methionine restriction may need to be explored further in carnivore-heavy metabolic protocols

● Glucose spikes—even brief—can potentially feed tumor cells, so cycling must be deliberate and tightly monitored● Even terminated trials can offer valuable conceptual guidance when interpreted wisely

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