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I'm thinking about giving Cagri a try. I am on Zepbound 12.5. Almost at 2 years. I do not have the appetite suppression like I used to. Gained 4 lbs and i cant get it off. I have already done Zep 15.0 and just recently went back down to 12.5. Hoping Cagri will help. Maybe I will take advantage of the Jade Nexus deal. Anyone try theirs? Do I mix that with Bac water? If I'm just starting out 5g should be enough for a month?

Medications (Peptides) like TRZ, Sema, and RTA work by strongly slowing stomach emptying, reducing appetite, and changing how the brain and gut communicate about hunger and fullness. When these drugs are started at too high of a dose or when someone is especially sensitive, the effects can become too strong too fast. This often shows up as severe nausea, vomiting, diarrhea, abdominal cramping, weakness, shaking, and profound fatigue. In simple terms, the stomach and intestines can become over-slowed and overstimulated at the same time, making it hard to keep food or fluids down and leaving people feeling miserable. While nausea and GI upset are known side effects, severe or persistent symptoms usually mean the dose exceeded what the body can tolerate at that moment, rather than just normal adjustment. Most of the time this is not dangerous by itself, but it can become risky if dehydration or electrolyte imbalance develops. Warning signs that need medical attention include not being able to keep fluids down, very dark or minimal urine, dizziness or lightheadedness, severe or worsening abdominal pain, or ongoing vomiting. The good news is that for most people symptoms improve as the medication level slowly falls over several days. Many individuals can still use these medications successfully later if they restart at a much lower dose and increase more slowly. During an acute reaction, the priorities are hydration first—taking small, frequent sips of water or electrolytes, eating bland foods only if tolerated, avoiding fatty, heavy, or spicy meals, resting, and using anti-nausea medication if prescribed or available. The focus should be on preventing dehydration, not forcing calories. Prevention is key. The safest approach with GLP-1 receptor agonists is to start low and go slow, increase doses only after symptoms are well controlled, avoid stacking similar drugs, and respect individual sensitivity. Rapid dose escalation or starting too high is the most common reason people experience severe side effects.

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