3d (edited) • General discussion
TESOFENSINE
Many of you have concerns about appetite suppression. I came across this little hidden gem and wondering if anyone has experience with it? I sure wish I would have known about this when they had me on steroids a few weeks ago and I was eating everything in sight!! 👀 Supposedly it's stronger than Phentermine? I've taken Phentermine before and all it did was make me HUNGRIER. This seems to be a legit option to Cagri. Not to mention the 9 day half life. 😲
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Tesofensine is a triple monoamine reuptake inhibitor (dopamine, norepinephrine, serotonin) originally investigated for neurodegenerative disorders and later recognized for its potent appetite-suppressing and metabolic effects. It is not a peptide and is most commonly discussed in the context of medical weight management.
Key Benefits:
1. Appetite Suppression
- Strong central appetite control via hypothalamic signaling
- Reduces hunger, cravings, and food preoccupation
- One of the most potent pharmacologic appetite suppressants studied
2. Weight Loss & Fat Reduction
- Produces significant, sustained weight loss in clinical trials
- Fat loss appears disproportionate to calorie reduction alone (metabolic effect)
3. Increased Energy & Motivation
- Dopaminergic and noradrenergic activity can increase drive, alertness, and adherence to lifestyle changes
4. Metabolic Support
- May modestly increase resting energy expenditure
- Helps counter metabolic slowdown during caloric restriction
5. Possible Cognitive Effects (Secondary)
- Improved focus and mental clarity reported anecdotally
- Originally researched for neurological indications
Typical Dosage Ranges (Clinical / Off-Label Use)
Low Dose (Beginner / Sensitive Users)
- 0.25 mg once daily
- Often used for tolerance assessment
Moderate Dose (Most Common)
- 0.5 mg once daily
- Effective appetite suppression with manageable side effects for many
Higher Dose (Advanced / Clinical Upper Range)
- 1.0 mg once daily
- Strong effects; higher likelihood of side effects
Doses above 1 mg/day significantly increase risk and are not generally recommended.
Administration Notes:
- Taken orally, once daily
- Often dosed in the morning to avoid insomnia
- Long half-life (~9 days) → effects accumulate over time
- Full effects may take 1–3 weeks to stabilize
Common Side Effects (Dose-Dependent)
- Increased heart rate
- Elevated blood pressure
- Insomnia or restlessness
- Dry mouth
- Nausea (usually transient)
- Anxiety or overstimulation at higher doses
*Important Safety Considerations
- Not suitable for individuals with cardiovascular disease, uncontrolled hypertension, or arrhythmias
- Avoid combining with other stimulants (e.g., high-dose caffeine, clenbuterol, sympathomimetics)
- Should not be stacked casually with serotonergic or dopaminergic medications
- Long half-life means side effects may persist after discontinuation
Comparison Note:
Tesofensine is far more potent per milligram than agents like:
- Phentermine
- Bupropion
- GLP-1 agonists (mechanism differs)
It acts centrally rather than hormonally.
Summary:
Tesofensine is a powerful appetite suppressant and weight-loss agent with significant efficacy at very low doses. Its strength and long half-life demand careful dosing and respect for cardiovascular risk, but when used appropriately, it can be one of the most effective pharmacologic tools for fat loss.
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TESOFENSINE
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