MK-677 (Ibutamoren) — The GH Secretagogue With Real Tradeoffs · DadBod2Fit

Jan 20 • SARMs

MK-677 (Ibutamoren) — The GH Secretagogue With Real Tradeoffs

What it is: A growth hormone secretagogue (not a SARM) that drastically increases GH and IGF-1 in humans.

Research snapshot: There is human clinical research showing increases in GH/IGF-1 and changes in body composition markers, but outcomes vary and side effects are common.

Mechanism:

Mimics ghrelin signaling → increases GH pulses → raises IGF-1
Often increases hunger and can change water balance

What users report (common):

Increased appetite (very common)
Better sleep quality (some), vivid dreams (some)
“Fuller” look / scale weight increases (often water + glycogen)
Improved recovery perception

Common issues / risks reported:

Water retention / edema
Lethargy in some
Increased appetite can wreck fat loss
Glucose/insulin markers can worsen in susceptible people (a big one)
Blood pressure can creep via water retention

Reality check: MK-677 is popular because it “feels” like something is happening (hunger + water + sleep). But the long-term win depends on whether you manage the tradeoffs.

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Did MK-677 help sleep/recovery—or did appetite and water retention outweigh the upside?

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