I use KE4, but it wont cause weightloss, no more than taking in carbs or protein will. The ketone esters just provide nutritional energy in an ketone efficient manner. Now, the best way to use the KE4 is for when doing long duration cardio, if I run 10miles fasted and pull myself into ketosis based on verification with a glucose-ketone monitor, then I can use KE4 to keep myself in that system while replenishing energy. Example: if I run 10miles, blow through my glycogen, now my bloodglucose drops, I need energy say to run/walk 5 more miles, I'll blast a KE4 rather than taking glucose. Then before bed if this was done in the afternoon, blast more KE4, go to bed. Get a solid 20hrs of ketosis for weightloss before eating again. This is a great AMPK pathway use with it, it in my opinion is not good for mTOR or micronutrients or macronutrients.

@Mike Schultz no feeling, but the ketones are measurable with a ketomojo. Its just a matter of how you use the energy, it has a place in targeting ketosis or reducing inflammation post event.

I dont use IGF-1LR3, but from my understanding using it can cause hypoglycemia easily with a very controlled diet. The best thing I can offer here is to track it, a continuous blood glucose monitor, a normal glucose monitor, Ketomojo, or a lumen for a less precise but a general trend to monitor where you are. This way you can figure out when and where to add carbs for optimal use of the igf-1 addition.

Is this for you? It sounds like a FODMAP issue, something you are eating is causing problems. I would look at an elimination diet or maybe see a dietician to sort that out. As for increasing appetite while managing glucose, this could be a recipe for GHRP-6 and a low dose GLP-1, but before going polypharmacy, I would look at what is causing the diarrhea in the diet.

Not a doctor, but trying to break through a plateau with a GLP-1 dose escalations is generally not advisable, in my opinion. I assume the escalation is to lower food noise, but is that all that the drugs does? No. GLP-1s provide a great opportunity to shift lifestyle and food associations in addition to blood markers. Example if the food noise is based on association, is there always snacking when they get home from work, snacking after dinner, or snacking while doing (insert association). I personally believe that using GLP-1s to target food noise with constant escalation creates a negative feedback loop with the ghrelin receptor processes. If you constantly remove the hunger sensation, you negatively affecting all of the downstream value that ghrelin does offer with GHRH, GH, IGF-1, etc. Then with reduced GH you will have more muscle loss, more bone mineral density loss, ect. So in the balance here, I wouldnt just keep escalating, I would target the other part of the equation with weightloss and quality of life. Less focus on calorie in and more focus on calorie out. This is where I would look to better harness other aminos like Leucine and L-Carnitine (1g dose with fasted cardio along side 5-10g acetylated L-Carnitine or 10g of Leucine with 50g of carbs with hypertrophy training). Add in proper vitamins and minerals (vit D, zinc, C, B12), eat foods that are higher nutriental value with less desire. When it comes to snacks, I use my PF11 method (something I made up), any snacks I buy and stock the pantry with are total calories divided by adding protein and fiber together, if the ratio is over 11, I dont buy it. Further introduce peptides that can offset some of the issues of dose escalated GLP-1s like CJC, ipa, etc. Lastly, if the person has a tanked T3 or is feeling cold all of the time, has severe unattachment, etc. It might me time to back off the higher doses GLPs to get back to feeling happy and human, even if their body image is short of their personal goal. They can return to normal and then start the weightloss journey again, nothing goes up or down in a straight line in a heslthy fashion, not stocks, not planes, and not weight.