Hey everybody, coming to you from a very snowy Michigan, 10" dropped last night and still snowing. God is good and blessed me with a back that allowed me to shovel a 8 car long, double wide driveway, plus extra, of wet, heavy, nasty snow!! I hope you all are well and wanted to bring an update. I decided to try Rythm Health. This is my experience to this point. I ordered last Wednesday, December 3rd at 1004 hrs. It went from San Francisco, CA to Saginaw, MI by Friday, December 5th at 1610 hrs. It was delivered at 1115 hrs Monday, December 8th (order before Wednesday and you should get it same week). I did my blood draw Tuesday, December 9th at 0630 hrs (fasted). I also made my very first content video and the file was too large to upload. But it was super simple and easy to follow videos. I dropped the sample off at FedEx in Saginaw, MI at 1230 hrs Tuesday, December 9th. It arrived at the lab in Omaha, NE at 1004 hrs this morning, December 10th. HOLY SHIT!!! Now to see how long for results, hoping Friday. Off to play on the trails in my toy!!

Everyone's been asking me about Jay Campbell's recent podcast where he claimed GLP-1s are about to be completely shut down in the research and compounding space. His prediction? Eli Lilly is coming with lawsuits, Trump cut a deal, and by 2026 you won't be able to get sema or tirz anywhere except through prescription at their new "discounted" prices ($199-$299/month). Here's my issue: Jay spent half that podcast selling a $1,200/month follastin product. So when someone's pushing expensive products while saying affordable options of proven peptides are disappearing... 🤔 That said... Eli Lilly just hit a $1 TRILLION market cap. A monopoly on GLP-1s makes perfect business sense. And we saw what happened with SS-31—these shutdowns CAN happen fast. Speaking of SS-31, Ben and I covered that rapid shutdown in our podcast. If you want to see how quickly things can change in this space, check it out: 🎥 YouTube: https://youtu.be/oCjljZn2ZoU 🎧 Spotify: https://open.spotify.com/episode/5KkQvR4xvgYKD1hLG7vKV7 📝 Show Notes: https://open.substack.com/pub/beyondthevial/p/beyond-the-vial-episode-2-black-friday My take? I don't think it'll be as dramatic as Jay claims, but I also wouldn't completely ignore the warning. Should you stock up? Maybe. Should you panic? No. I break down the whole situation, the political angle, what this could mean for research vendors, and what you should actually do about it. Read the full article here: https://open.substack.com/pub/derekpruski/p/will-glp-1s-disappear-from-the-research?r=4jq1x8&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true ⚠️ Full disclosure: This is 100% my opinion and speculation. I don't have insider info. Just giving you my honest take based on what I'm seeing.

Seeing a lot of frustrating DMs and comments about vendors not responding to reconstitution or dosing questions. Let me be clear about why: Research peptide companies legally CANNOT answer these questions. When you ask "how do I reconstitute this?" or "what should my research protocol be?" - you're implying human use. These companies operate under "research use only" licenses. The moment they provide guidance on human protocols, they're crossing a legal line that could shut them down entirely. Now I'm even seeing credit card processors won't allow vendors to respond to questions about cloudy peptides or peptides that gel up. This is getting even more restrictive - payment processors are cracking down hard on anything that could remotely imply human use. It's not that vendors are being unhelpful or ignoring you - it's a legal and financial liability they literally cannot take on. This is why this community exists. This is why we share information with each other. You're choosing to conduct your own research, which means YOU are responsible for educating yourself on: - Proper reconstitution techniques - Storage requirements - Research protocols - Safety considerations - What cloudy/gelled peptides mean Don't get upset with vendors for protecting themselves legally. Be smart, do your research, and take responsibility for your own decisions. Check the guides in the classroom section if you need help with the basics. 👊 Remember This Community Is All Anecdotal and Research Based. Not Medical Advice so DO Your OWN Research Please.

The first episode of Derek's Declassified Research Survival Guide just dropped, and we're starting with a conversation that challenges everything most people think about using peptides for weight loss. I dropped a sneak peek of the podcast below - check it out and let me know what you think 👇 I sat down with @Laura PepFitCoach , a holistic peptide coach who spent years in the pharmaceutical industry and military before discovering the truth: peptides are tools, not magic bullets. Here's what we unpacked: ✅ The 3-Phase Framework - Why starting with peptides without a proper foundation sets you up to fail ✅ Exit Strategies - The most overlooked part of peptide therapy. What happens when you come off? How do you maintain results? ✅ The Nutrition Reality - You can't out-peptide a bad diet. Laura breaks down why nutrient density and proper eating habits matter more than the compound itself ✅ Metabolic Damage - How crash dieting and bodybuilding-style approaches destroy your metabolism and what to do instead ✅ The Mental Game - Both of us share our transformation stories (my 70lb journey, her 50lb COVID gain) and the psychological work required for lasting change Huge shoutout to Laura for being incredibly transparent about her journey and methodology. This is the kind of real, educational content this community deserves. This episode reinforced what we talk about here every day: education over hype, foundation over shortcuts, sustainability over quick fixes. 🎧 LISTEN NOW: Spotify: https://open.spotify.com/episode/2lcU2zkYIG255aGk0aIJjW?si=kIAm0BT3QCiClyHj-372KQ YouTube: https://www.youtube.com/@Derberfn Substack (Full Podcast): https://open.substack.com/pub/derekpruski/p/why-you-cant-out-peptide-a-bad-diet?r=4jq1x8&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

1. The Official FDA Name Change (The "Cease and Desist" Cause) ​The primary reason you may be seeing name changes or product removals is that SS-31 received FDA approval in September 2025. - ​New Brand Name: Forzinity - ​Generic Drug Name: Elamipretide - ​Indication: Barth Syndrome (specifically to improve muscle strength). - ​Manufacturer: Stealth BioTherapeutics. ​Why this matters: Once a peptide becomes an approved FDA drug (Forzinity), it is legally removed from the compounding/research chemical "exempt" list. This triggers cease-and-desist letters to vendors, forcing them to stop selling it or change the name to hide it. ​2. Alternative Names (Research & Gray Market) ​If you are looking for SS-31 on research sites (like Peptira or others) and cannot find it, they may have relisted it under one of its chemical synonyms to avoid automated filters: - ​Elamipretide (The most common chemical name) - ​MTP-131 (An older development code) - ​Bendavia (A previous potential trade name) - ​D-Arg-Dmt-Lys-Phe-NH2 (The chemical structure often used on labels)