Beyond diet and exercise, there are safe, natural adjuncts for managing blood glucose levels. We've identified seven substances that are scientifically validated as among the best drug-free therapies for blood sugar problems. From ensuring that you get adequate amounts of critical vitamins and minerals to strategic calorie restriction, these approaches can elevate your wellness while helping to keep your glucose in check. 1. Vitamin D Vitamin D, also called calciferol, is vital for everything from building strong bones and muscles to helping the immune system fight off illness, among other crucial functions. Maintaining adequate vitamin D is essential if you are at risk of diabetes. Vitamin D deficiency has been linked to insulin resistance, a key factor that marks the progression from prediabetes to an official Type 2 diagnosis. A 2019 study reported that vitamin D deficiency was found in 70% of Type 2 diabetic patients, and that individuals with severe vitamin D deficiency were 39 times more likely to have a diagnosis of Type 2 diabetes. Studies further show that correcting this deficiency through strategic supplementation results in improve glucose tolerance and beta-cell function, a marker of improved insulin secretion. Overall glycemic outcomes were measured in two separate meta-analyses published in 2018, one of which reviewed 28 controlled clinical trials involving nearly 4,000 adults who were prediabetic, overweight, or obese. Results showed that vitamin D supplementation significantly improved glycemic measures and insulin sensitivity. The other 2018 meta-analysis reviewed 37 studies and found that boosting vitamin D through strategic supplementation led to significant improvement in fasting blood glucose and improved insulin resistance in Type 2 diabetics. Vitamin D can be a safe part of a preventative strategy and may even help reduce inflammation associated with diabetes. 2. Magnesium Another nutrient that plays a key role in glucose metabolism is magnesium (Mg). Required by the pancreas for insulin production, being deficient in Mg is associated with increased risks for many diseases, including Type 2 diabetes. Conversely, higher dietary magnesium intake is associated with lower diabetes rates in some studies.