This research is actually more important that I initially realized* We may be able to target abdominal regions (no more spleen location - which is difficult) if this research holds up and expands further, I don't see why it wouldn't scale up, this could be massive for US-1000 and US-2000 Pro owners, you guys are so darn lucky ! Recent research confirms that transcutaneous focused ultrasound applied to the epigastrium suppresses systemic inflammation by modulating subdiaphragmatic vagus nerve fibers. This non-invasive approach utilizes acoustic pressure to stimulate mechanosensitive vagal afferents. In controlled rodent models, a 10-minute application at 1 MHz resulted in a 180% increase in vagal firing. The physiological result is a significant downregulation of pro-inflammatory cytokines. Data shows a 48% reduction in TNF-α and a 42% drop in IL-1β within two hours of stimulation. The mechanism targets the cholinergic anti-inflammatory pathway. By increasing efferent tone, ultrasound signals the spleen to inhibit cytokine release via α7nAChR receptors on macrophages. Human feasibility trials demonstrate a 30% cytokine reduction. This bioelectronic intervention offers a precise, drug-free alternative for managing rheumatoid arthritis, IBD, and sepsis. https://pubmed.ncbi.nlm.nih.gov/41671184

Simple abdominal 1MHz Ultrasound helped drastically reduce Inflammation via a Vagus Nerve Mechanism. Have you kiddos been doing your Ultrasound ? When would “now” be a good time ? Just curious ;) Recent 2026 research confirms that non-invasive abdominal ultrasound can directly modulate systemic inflammation. Using Low-Intensity Focused Ultrasound (LIFU) at 1.0 MHz, researchers successfully targeted subdiaphragmatic vagus nerve fibers. Acoustic pressure waves mechanically depolarize these fibers, triggering the cholinergic anti-inflammatory pathway. This process engages α7 nicotinic acetylcholine receptors on splenic macrophages to suppress cytokine production. The study observed a 40–60% reduction in serum TNF-α, IL-6, and IL-1β levels. Electrophysiological data confirmed that vagal firing rates increased up to three times the baseline during active stimulation. This bioelectronic intervention offers a precise, drug-free alternative for managing conditions like rheumatoid arthritis and sepsis. Histological analysis verified no adverse tissue effects, validating LIFU as a safe modality for clinical neuromodulation. https://pubmed.ncbi.nlm.nih.gov/41671184

I get a bajillion questions about this "Vagus Nerve" thingy - and good news - there are answers for you ! Here's the link to first Module on the Science of the Vagus Nerve: https://www.skool.com/vagus/classroom/11773e6a I strongly encourage you to go, and noodle around, Vagus School is the fastest growing VNS group on the planet right now - get in early ! (It's free and will always be free! But still "get in early" too :P ) Meet the Vagus Nerve: the body’s longest, chattiest, and most overachieving internal messenger. Think of it as a high-speed fiber-optic cable running from your brainstem to your gut, stopping at the heart and lungs for status updates. It’s the ultimate "chill out" button, whispering sweet nothings to your pulse while simultaneously supervising your digestion. Ever wonder why "gut feelings" are so loud? That’s just the Vagus Nerve gossiping between your brain and your belly in real-time. It’s also a master of the "cholinergic anti-inflammatory pathway"—basically your body’s built-in fire extinguisher for stress. In Module 1: Foundations of Vagal Science, we demystify this biological superhighway and its role in keeping you resilient. From Stephen Porges' Polyvagal Theory to the secrets of social safety, we’re diving deep into the anatomy of zen. Master your internal peacekeeper. Your sanity will thank you.

This is a Free to Join Skool Community! A community designed to help people Stimulate and Repair their Vagus Nerve! Comment Below! - What you know about the Vagus Nerve 🦄 - Your preferred method of Vagus Nerve Stimulation ? (Breath, TENS, Ultrasound, etc?) 👩‍💼 - A Want or Have Had Experience from Vagus Nerve Land !? (A win, or something you are striving for) And when you comment, like a post, get 5 likes across your comments, and click "Complete" on a few of the modules in the Classroom, you can then unlock the Ultrasound module ! YAY ! So, I hope this can become a great community page, it's very open, and you have access to SO MUCH good information, actionable information, on the Vagus Nerve, and all the ways you can make it happy and healthy ! So from the Vagus Skool to you and yours... WELCOME !