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Castore: Built to Adapt

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TPC ARMY

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28 contributions to Castore: Built to Adapt
Vesilute peptide
Has anyone here tried the Vesilute peptide? I have had bladder issues since transitioning to menopause and I am thinking of trying it.
0 likes • 6h
@Nicola Lewis You didn't mention your Estrogen blood test? Cheap full test at: hellogoodlab.com . Then hormones at hormonesforme.com Estrogen needs to be >>90 and 150 is good. To offer blader control. A newer product called: estrogen vaginal ring at 4mg lasts 3 mo then swap out works very good. But the ring is just for vaginal and incountanence help a women needs topical estrogen to get >>90. Also hormonesforme.com will also mix in testosterone to bring that up >>50 for total health. If needed thryroid needs to be free-T3>> 3.2. Best is NP thyroid desicated porcine thyroid is by prescription from a local Functional clinic. I guessed that your question about "bladder" and menopause was actually an incountance issue which is 100% low estrogen. Some make excuses that its loss of muscle tone which is Estrogen and Testosterone based... HRT needs all hormones up to 40yo levels. Reply if my guessing missed your need? Take care, curt
NAD Supplementation
In the latest DDT Method podcast with @Anthony Castore , Anthony discussed NAD supplementation. What I found interesting is that Anthony seemed to be against NAD supplementation via NAD+ and its precursors if I understood correctly, and a more appropriate approach would be to instead use a combination of 5 amino and 1MNA. He suggested using 5 amino pre workout and 1MNA on rest days in the evening. Anthony - would you be able to expand on your thoughts regarding NAD supplementation given it seems like a given in the longevity community that you supplement with NAD+ (injection or IV) or its precursors (NMN, NR).
0 likes • 20d
@Damian Perez tnx ya so far single source. Found a 10% discount code, welcome Bought subscription... 🤣. Typical $30/mo is now $80... 😂😂😂
0 likes • 6h
@Joaquin Rodriguez https://ohphealth.com/products/endoteliol-1mna
Glutathione
How are we dosing glutathione?
1 like • Feb 27
But some say per Anton inferred, to dose with glutathion only when sick or some low point. If healthy and eating well, taking modest precursors, NAC, Glucine etc, no need normally.
0 likes • 6h
@Rob Taylor IMHO like injecting / IV NAD, glutatione has a narrower best use case then Bro's just injecting willy nilly. Theres negatives with shutting down ones endogenous glut production. But injecting 500mg of Test is not uncome either. I belive Anton was trying to be helpful. I'm not being quipe but trying to stick to what actually works health wise. I have a stash of injectable Glut as well but don't do it unless I'm sick as a dog and even then I suspect Anthonie would have more helpful timing inputs. Best to all, curt
Women’s Health after Ovary Removal and Early Onset Menopause
Hello out there to all of you brilliant and beautiful people. I truly hope this is appropriate on this platform, but here it goes! My question is about women and menopause and oophorectomy. Specifically My beautiful wife age 49 of 28 years. The major things she is suffering from are poor sleep, joint pain and stiffness, hot flashes, low energy, mood swings, anxiety, brain fog, very low libido, vaginal dryness and pain with intercourse. I have utilized this wonderful community, including an amazing consult with @Anthony Castore (highly recommend) and have totally turned around my own personal health journey. I’m 51 and in better shape and better health than I was when I was in my 30’s. My wife is suffering and I want to help her figure out how to feel as healthy and vibrant as I do. I tried to incorporate some of the things I’ve learned that helped me, but unfortunately when it comes to the opposite sex, things get messy, and I just don’t know enough about women’s health to giver her the right direction to head. I’ve talked with her about the importance of movement, sleep, nutrition, sunlight, heat, cold, and all of the foundational things I’ve learned about, but she complains that she’s so miserable she doesn’t have the energy or motivation to do even the simplest things. Some quick things about her background health. Tonsils removed at 27, hysterectomy at 30, 3 years ago diagnosed with massive ovarian cysts and at the advice of her OBGYN had her ovaries removed. She also occasionally gets nasty kidney stones. Also suffers from pretty extensive varicose veins in her lower legs from the knees down. Also has Occasional water retention and swelling in her ankles. Family history of autoimmune disease (father) I personally think the major issues have happened since her ovaries were removed and maybe symptoms of early onset Menopause. But I just don’t know what to think anymore. Current Supplements: Urolythin A D3 K2 (we live in the north with little sun)
0 likes • 7h
Hi Travis, Thank you for posting. My personal view of this group is that we want to raise the health and happiness of everyone through helping each other... Forgive me ahead of time... I get really upset over the poor health care women receive, mostly in omission and I have a hard time holding back... I will try to bullet point my thoughts. - You didn't mention having a Functional medicine providor / clinic / concierge? IMHO this would be a big help for both of you. On another thread possibly I have a technique for searching an area for better clinics and what to ask when calling and talking to the office manager. - You didn't give estrogen dosing. This is a big omission. - You didn't mention you guys getting both of you periodically full blood tests yourselves, this is big. We need to take back self health care FROM providors into our own hands. (Obviously re the current state of our health). - Cheap blood tests; Each of you get the full test at hellogoodlabs.com. BUT hellogoodlabs left off important markers especially for men; Please both add DHT, Progesterone and IGF-1 to both of your full tests. - She gets her blood test back then contact this hormone provider who is a member here: hormonesforme.com. Also good place for your to buy testosterone. Unfortunately they do not do thyroid. I have helps for low free-T3 under 3.2. - I have lived with a wife who's studied female hormone protocols and struggled to get all issues covered. Std Of Care does not cover but 10% thus your gap. Over some age and total historectomy qualifies I believe best Female Hormone care includes an estrogen vaginal ring product WITH topical estrogen that you will get from hormonesforme.com. The ring needs to be prescribed by a practioner and this is where a local Functional clinic is neccessary. A 4mg estrogen ring helps with vaginal attrophy (painful sex) and possible present and certainly future incountenance issues. I'm certain that the ring is a necessary benefit after some age like 50ish, certainly older. Topical E does not do enough for vaginal regeneration/restoration/maintaining for most aging women. More on restoration later. I'll post a picture of the vaginal ring box. Make sure I remember. - In the end and will take many months: total Estrogen blood test needs to be >90 to 150. Total testosterone >50 and up to 100 is good but at least 50. Many of your listed symptoms are due to no testosterone. Free T3 >3.2. I hope her thyroid is still functioning.
PART 3 The Decision Engine: How to Choose What Comes Next
Once the foundation is stable, the question changes. You are no longer asking what should I take every day. You are asking what exactly needs to change in the system right now. Take a simple example. Two people both feel fatigued. One uses caffeine and feels worse, more wired but less productive. The other uses caffeine and feels better, more focused and energized. Same symptom, completely different response. The difference is not the tool. It is the state of the system it was introduced into. This is where most people fall back into old habits. They feel better, they add more. They hear about something new, they layer it in. The system improves slightly, then becomes inconsistent again. Not because the tools are wrong, but because the decision process is missing. Most people are not lacking options. They are lacking precision. More inputs without a clear target create more noise, not more progress. If Part 2 was about stabilizing the terrain, Part 3 is about building a repeatable way to make decisions inside that terrain. Not guessing. Not copying protocols. Not chasing trends. Identifying what the system is doing, what it needs to do differently, and selecting the smallest input that can create that shift. This decision engine sits on top of a stable foundation and downstream of environment and circadian inputs. Without that context, even the right decision can produce the wrong outcome. This is the point where most protocols quietly lose precision. The decision process can be simplified into three steps. Identify the bottleneck, define the direction of change, and match the mechanism to the goal. The first step is identifying the bottleneck. Not the symptom, but the constraint underneath it. Two people can both feel fatigued and have completely different bottlenecks. One may have a system that is over-reduced, where electron supply exceeds the system’s ability to process it, creating a backlog of pressure through the electron transport chain and inefficient energy production. Another may have a system that is underpowered, where there is insufficient substrate or signaling to drive adequate ATP production.
0 likes • 3d
@Anton Sh Tnx alot Anton. I'm 72yo and been on HRT for >15 yr. Just post Jan '26 had this problem post a bad 4 week bout of a wierd flue which may not be related. Along the way the total pill stack seems to have upped my blood testosterone even though dosing has not changed along with higher Estrogen and probably DHT. Other prrotocol changes may have changed without my appreciating.. I'm listing to Cortex labs on youtube, Thanks BTW, and bought but not recevied his $49 libido tutorial. Mean time between Cortex and Vigorous Steve's talks; My estrogen at 52 is way way too high and may be the root of lose of libido. Ideal is 20-35 ish. My same dose of TRT exact mg of cypionate 180mg/wk in 2 doses was dialled in for 1100 T and 35 ish E for many years but with boron, bioregulators testagen and most of the other bioregulators I'm now certain I need to drop to probably 140mg T / week. Of course retest often. Maybe DIM very near term. The full test at hellogoodlabs.com frustratingly does not include DHT or LGF-1. I think I have a near term todo list; drop T to drop E and see where DHT falls. I've always had top of range but still in range DHT. Virgorous and Cortex talk of adding a small amount of HCG like 150u ish 2x a week. Vigorous likes decent sized doses of Semax as a small libido boost and oxytocin just prior. I think getting Estrogen down to 35 will be a good place to fine tune per my current studies. Tnx curt
0 likes • 3d
@Anton Sh We are a deep study of our health. Its common mis conception that micro biom diversity on a carnivore diet is poor. My biotests show wide and high diversity. it shut my Functional guy up who had the same pitch. The carivore Drs / researchers are finding fiber may be useful for some but its not the end all and for carnivor at 1.5gr/2.2# range for us anyway AND the carnivore researchers biom diversity is actually excellent. But I''ll not evangelize and say its the end all, not all all. I've come around to various body types and their varying benefiting from a range of diet types. Fortunately for both of us we are both wolves. It'll be nice rubbing shoulders with fellow carnivor-ites at this convention next mo: https://meatstockconvention.com/ I hate the name. We preferred our going to the Metabolic conferences and then the Low carb conf's. Less in your face. But thanks for the iron and libido tips and a detailed post. I'm reading your URLs. Thank you, curt
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Curtis Smith
3
40points to level up
@curtis-smith-7832
72yro male, 164#, 5'10", 31" waist, healthy, active, poly-nutricals, rapamycin 4yr, SGLT-2 etc, anti-aging / health span interests. Atlanta Georgia.

Active 5h ago
Joined Dec 26, 2025
Atlanta, Georgia, USA
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