Alright, so Lilly dropped their TRIUMPH-4 Phase 3 data yesterday for retatrutide. 28.7% weight loss. 71 pounds average. At 68 weeks. If you've been paying attention to triple agonists, this shouldn't be surprising. The Phase 2 data already showed us where this was headed. But now we have the Phase 3 confirmation. Here's what happened: 445 people with obesity and knee osteoarthritis. Split into three groups - 9mg retatrutide, 12mg retatrutide, and placebo. The 12mg group lost an average of 71.2 pounds. That's 28.7% of their starting weight. Compare that to tirzepatide's ~21% in Phase 3. That's 8 percentage points higher. The glucagon agonism makes the difference - you're not just suppressing appetite, you're ramping up energy expenditure and fat oxidation. Why triple agonists hit different: Retatrutide is GIP + GLP-1 + Glucagon. You already know GLP-1 from semaglutide. You know the dual combo from tirzepatide. The glucagon piece is what pushes this into a different category. - GLP-1 = appetite control - GIP = metabolic optimization - Glucagon = fat-burning accelerator You're hitting all three mechanisms simultaneously. The inflammation piece is wild: This trial was designed for knee osteoarthritis, not just weight loss. The pain results were massive: - 76% reduction in pain scores - 74% improvement in physical function - 12% of people completely pain-free by week 68 But here's what's interesting - this wasn't just about losing weight and reducing load on the joints. Retatrutide crushed inflammatory markers across the board. hsCRP dropped significantly. Triglycerides down. Blood pressure down 14 mmHg. Each component has anti-inflammatory effects. GLP-1 reduces pro-inflammatory cytokines. GIP has protective effects on bone and cartilage. Glucagon ramps up fat burning, and less adipose tissue means less inflammatory signaling. You're not just taking pressure off the knee - you're turning down systemic inflammation that's driving the pain in the first place.

Did a podcast this morning and it reminded me about something important—there are so many new people in this space, especially those of you starting tirzepatide or retatrutide, who might be making critical mistakes without even realizing it. Let me share some context. I was lucky enough to get into tirzepatide NOT wanting to lose 70 lbs—I did that part before. I started tirzepatide to calm that overall food noise and stay at maintenance. I'm also the type of person who will do months of research and figure out everything about a peptide before I dive in. As part of that research, I already understood proper dieting and the dangers of putting yourself into too harsh of a deficit. So let me break this down for you: If you're feeling tired, nauseous, and can't eat—your dose is too high. Here's what's actually happening in your body when you push the dose too hard: GLP-1 agonists like tirzepatide work by slowing gastric emptying (how fast food leaves your stomach) and signaling satiety centers in your brain. When you dose too aggressively, you're essentially slamming the brakes on your entire digestive system. The nausea isn't just discomfort—it's your body telling you it can't process what's happening. Can't eat → You're losing muscle. When you're in a severe caloric deficit, your body doesn't just burn fat. It breaks down muscle tissue for amino acids through a process called gluconeogenesis—literally converting protein into glucose for energy. Muscle is metabolically expensive for your body to maintain, so when resources are scarce, it's one of the first things to go. And for those of you on tirzepatide specifically—this is even more pronounced. Tirzepatide is a dual agonist hitting GLP-1 and GIP receptors, but it has no glucagon receptor activity. Retatrutide, on the other hand, is a triple agonist that includes glucagon receptor activation. Why does this matter? Glucagon signaling helps mobilize fat for energy and has some muscle-sparing properties. Without that glucagon component, tirzepatide users need to be even MORE intentional about protein intake and resistance training to protect lean mass.

I want to leave a review, and I forgot where the link is.

I accidentally put 3 mL of BACC water in my Reta (thinking it was my KLOW) now I don’t know what dosage to do my Reta at? It was a 10mg vial and I was doing 20 units…

Hey everyone, I wanted to try something different today and create a comprehensive tier list breaking down the most popular energy peptides in the research space. PSA Much Better On Substack: https://derekpruski.substack.com/p/breaking-down-energy-peptides-my If you've been following my work at PeptidePrice.store, you know I'm all about transparency and helping people make informed decisions. So I thought it would be valuable to share exactly how I view these compounds and why I rank them the way I do. Understanding Energy Peptides Before we dive into the rankings, let's clarify what we're talking about. Energy peptides primarily work through two mechanisms: 1. Mitochondrial optimization - Improving ATP production and reducing oxidative stress 2. Metabolic enhancement - Increasing NAD+ levels and improving glucose utilization These compounds don't give you a caffeine-like jolt. Instead, they work at the cellular level to improve your body's fundamental energy production systems. My Energy Peptide Tier List 🔴 S Tier (Best-in-Class) SS-31 (Elamipretide) This is the gold standard for mitochondrial protection. SS-31 is a potent mitochondrial protector that enhances ATP output while reducing oxidative stress. The research behind this compound is incredibly robust, and it's specifically designed to target damaged mitochondria. If you're serious about cellular energy optimization, this belongs at the top of the list. MOTS-C A mitochondrial-derived peptide that directly boosts ATP production and increases glucose utilization. What I love about MOTS-C is its dual action - it not only improves energy production but also helps with metabolic efficiency. Perfect for those looking for "clean" energy without the crash. 🟠 A Tier (Excellent) 5-Amino-1MQ This one works differently - it inhibits NNMT, which leads to higher NAD+ levels. The result is increased metabolic rate and sustained energy. It's not quite S-tier because it's more indirect in its mechanism, but the NAD+ boost alone makes it incredibly valuable for energy optimization and fat loss support.