8d • Peptide Tips
Why Do Some People Feel Like Absolute GARBAGE When They Start SS-31?
Alright, let's talk about something that doesn't get discussed enough: that weird "feel worse before feeling better" phenomenon some RSs experience with SS-31 (Elamipretide).
One would think a mitochondrial peptide would make an RS feel like Superman from day one, right? More mitochondrial efficiency = more energy = let's gooo!
But here's what's actually happening...
The Mitochondrial "Spring Cleaning" Effect
SS-31 doesn't just make mitochondria work better - it literally helps the body identify and clear out the damaged, dysfunctional mitochondria that have been limping along. Think of it like this:
The body has been running a factory with 100 machines. Maybe 40 of them are barely functional - smoking, sputtering, producing more waste than product. But hey, they're still contributing something to total energy output.
Then SS-31 comes in like a new efficiency consultant and says "These 40 machines are actually COSTING more than they're producing. Time to shut them down and rebuild."
What This Looks Like In Research Subjects:
- Increased autophagy/mitophagy = the body is actively breaking down damaged mitochondria
- Temporary energy deficit = just shut down 40% of the (admittedly crappy) energy production
- Metabolic shifting = cells are reorganizing how they produce ATP
- Possible "herx-like" reaction = all that cellular cleanup creates metabolic byproducts
The Timeline:
Most RSs report this sluggish phase lasting anywhere from 3-10 days. Some RSs don't experience it at all (lucky). But for those who do? It can feel like moving through molasses.
What May Help:
- Lower starting dose - perhaps starting at 2.5mg instead of 5mg
- Support mitochondrial biogenesis - ensuring adequate B vitamins, CoQ10, magnesium
- Hydration - helps flush metabolic byproducts
- Light movement - not going hard, but not being completely sedentary either
- Patience - this is actually a sign the peptide is WORKING
The Payoff:
Once the body clears out the damaged mitochondria and starts building fresh, efficient ones? That's when RSs report the real SS-31 benefits - sustained energy, better recovery, mental clarity, the works.
Have research subjects in your studies experienced this with SS-31? How long did the adaptation phase last? Drop observations below 👇
Educational purposes only. For research use only.
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Why Do Some People Feel Like Absolute GARBAGE When They Start SS-31?
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