🧊 Why Am I FREEZING 24/7 on Tirzepatide or Retatrutide? | Probably My Favorite Article

Seriously - I went DEEP on this one.

"Why Am I FREEZING 24/7 on Tirzepatide or Retatrutide?"

I've been seeing this question EVERYWHERE in the community. Everyone's cold. Like, can't-stop-shivering, wearing-hoodies-in-summer, space-heater-at-your-desk cold.

And the surface-level answer is easy: "You lost insulation, duh."

But there is SO. MUCH. MORE. happening under the hood.

What I Discovered While Researching This:

This isn't just about fat loss. Your body is running a full-scale metabolic defense operation:

🧬 7 different physiological mechanisms all working together to make you cold

🔬 Metabolic adaptation that kicks in within THE FIRST WEEK of calorie restriction

🦋 Thyroid downregulation (even in people without thyroid issues) - your T3 drops significantly

🩸 Blood flow getting redirected away from your extremities

🧠 Brown adipose tissue changes that paradoxically make you colder

💪 The sneaky muscle loss that's stealing your body's heat generator

And here's the kicker - I found recent 2024-2025 research showing EXACTLY what happens to your thyroid hormones when you lose weight on GLP-1s. The data is wild.

But More Importantly: How to Fix It

The second half of the article is all about reverse dieting and strategic carb refeeds - the actual protocols that can help restore your metabolic function and warm you back up.

I'm talking:

Specific calorie increments
Why carbs are key for leptin and thyroid function
How refeeds work at the hormonal level
The actual timeline for metabolic recovery

This is the stuff bodybuilders have been using for decades that's finally making its way into the peptide space.

Why This Is My Favorite

Because when you understand ALL the mechanisms - adaptive thermogenesis, euthyroid sick syndrome, peripheral vasoconstriction, diet-induced thermogenesis, NEAT reduction - suddenly it all makes sense.

You're not broken. Your medication isn't "wrong." Your body is just doing EXACTLY what it evolved to do when it perceives an energy crisis.

And once you understand that? You can work WITH it instead of fighting it.

Read the Full Article Here:

👉 https://open.substack.com/pub/derekpruski/p/why-am-i-freezing-247-on-tirzepatide?r=4jq1x8&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

It's probably 5-10 minutes of reading, but I promise it's worth it if you're dealing with this (or just curious about the science).

P.S. If you're currently freezing on tirz or reta, you're going to want to read the reverse dieting section. Game changer.

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