Nov 3 (edited) • Peptide Tips
Why 5-Amino-1MQ Should Be the LAST Thing You Add to Your Cut 🔬
If you're thinking about adding 5-Amino-1MQ to your fat loss phase, pump the brakes. Here's why it should be the absolute last thing on your supplement list—not the first.
The Harsh Truth About 5-Amino-1MQ:
It's NOT a beginner fat loss tool. It's a specialized compound for a very specific situation: prolonged caloric deficits where your metabolism has adapted and fat loss has stalled.
What Is 5-Amino-1MQ?
5-Amino-1MQ is a small molecule that inhibits the enzyme NNMT (nicotinamide N-methyltransferase). When NNMT is blocked, it increases NAD+ levels in cells, which can enhance metabolic rate and fat oxidation.
Sounds amazing, right? Here's the catch...
Why It ONLY Works in Prolonged Deficits:
1. It Addresses Metabolic Adaptation, Not Fat Loss Itself
When you're in a caloric deficit for weeks or months, your body adapts by:
- Downregulating thyroid hormones (T3/T4)
- Reducing NEAT (non-exercise activity thermogenesis)
- Decreasing overall metabolic rate
- Increasing hunger hormones
5-Amino-1MQ helps combat THIS adaptation—it doesn't directly cause fat loss. It helps keep your metabolism from cratering during extended cuts.
2. Your Metabolism Isn't Adapted Yet (Early in a Cut)
If you're 2-4 weeks into a cut and fat is still coming off easily:
- Your metabolism is still running normally
- Your thyroid is functioning well
- You don't have a significant metabolic adaptation yet
Adding 5-Amino at this point is like putting premium gas in a Honda Civic—unnecessary and a waste of money.
3. The Basics Are What Matter First
Before even THINKING about 5-Amino-1MQ, you should have these dialed in:
- Consistent caloric deficit (tracked accurately)
- High protein intake (1g per lb bodyweight minimum)
- Regular training program
- Adequate sleep (7-9 hours)
- Step count/NEAT management
- Stress management
If ANY of these aren't optimized, 5-Amino won't save you.
When Should You Actually Consider 5-Amino-1MQ?
ONLY when you've hit these criteria:
âś… You've been in a deficit for 8+ weeks minimum
âś… Fat loss has noticeably stalled despite being compliant
âś… You've already tried diet breaks or refeeds
âś… Your training, diet, and sleep are 100% dialed in
âś… You need to push through the last 5-10 lbs of stubborn fat
âś… You're legitimately lean already (men <12%, women <20%)
This is an END-OF-CUT tool, not a beginning-of-cut tool.
The Bottom Line:
5-Amino-1MQ is a weapon for metabolic adaptation, NOT a first-line fat loss tool.
Think of it like this:
- Week 1-4: You're driving normally → Don't need 5-Amino
- Week 5-8: Slight slowdown → Still don't need it
- Week 8-12: Engine's struggling → Maybe consider it
- Week 12+: Engine's sputtering, you're lean but stuck → NOW it makes sense
Save your money. Use the basics first. Add 5-Amino-1MQ when you've actually earned the need for it.
Most people asking about 5-Amino are 20%+ body fat and haven't even tracked calories for a full week. Don't be that person.
Real talk: Have you tried 5-Amino? Did you actually need it, or were the basics not in place? Drop your experience below! 👇
P.S. Some people may get an initial bump if they are metabolically impaired, but there are better options.
Disclaimer: This post is for educational purposes only. Always consult with a healthcare professional before starting any new supplement or peptide protocol.
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Why 5-Amino-1MQ Should Be the LAST Thing You Add to Your Cut 🔬
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