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Dec '25 • Peptide Tips
🧬 The Uncomfortable Truth About GH Secretagogues and Age
Quick question: Why does your 25-year-old gym buddy get insane results from ipamorelin while you're seeing... modest changes at best?
It's not the peptides. It's not your source. It's biology.
Here's what I just published:
→ Why GH production drops 95% from age 20 to 60
→ Actual data showing how secretagogue response varies by age group
→ Why a 30-year-old might see 85+ ng/mL IGF-1 increase while a 60-year-old sees 15-20
→ The signaling cascade breakdown that happens as you age
→ Why exogenous GH works better for older populations (and why most can't legally access it)
→ Realistic expectations by age bracket with actual study data
The reality: If you're under 40, secretagogues can produce results that rival mild GH doses. Over 50? You'll still see benefits (better sleep, recovery, modest fat loss), but the dramatic transformations? Those require exogenous GH that most of us can't legally access.
I broke down the actual research, compared response rates across age groups, and explained exactly why your pituitary's "GH sponge" gets drier every year.
Read the full deep-dive here: https://open.substack.com/pub/derekpruski/p/the-truth-about-growth-hormone-secretagogues?r=4jq1x8&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
This is the conversation nobody in the peptide space wants to have honestly. But you deserve to know what to actually expect based on YOUR age and biology.
Drop a comment if this matches your experience 👇
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🧬 The Uncomfortable Truth About GH Secretagogues and Age
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