Breaking Down Energy Peptides: My Complete Tier List

Hey everyone,

I wanted to try something different today and create a comprehensive tier list breaking down the most popular energy peptides in the research space.

PSA Much Better On Substack: https://derekpruski.substack.com/p/breaking-down-energy-peptides-my

If you've been following my work at PeptidePrice.store, you know I'm all about transparency and helping people make informed decisions. So I thought it would be valuable to share exactly how I view these compounds and why I rank them the way I do.

Understanding Energy Peptides

Before we dive into the rankings, let's clarify what we're talking about. Energy peptides primarily work through two mechanisms:

Mitochondrial optimization - Improving ATP production and reducing oxidative stress
Metabolic enhancement - Increasing NAD+ levels and improving glucose utilization

These compounds don't give you a caffeine-like jolt. Instead, they work at the cellular level to improve your body's fundamental energy production systems.

My Energy Peptide Tier List

🔴 S Tier (Best-in-Class)

SS-31 (Elamipretide) This is the gold standard for mitochondrial protection. SS-31 is a potent mitochondrial protector that enhances ATP output while reducing oxidative stress. The research behind this compound is incredibly robust, and it's specifically designed to target damaged mitochondria. If you're serious about cellular energy optimization, this belongs at the top of the list.

MOTS-C A mitochondrial-derived peptide that directly boosts ATP production and increases glucose utilization. What I love about MOTS-C is its dual action - it not only improves energy production but also helps with metabolic efficiency. Perfect for those looking for "clean" energy without the crash.

🟠 A Tier (Excellent)

5-Amino-1MQ This one works differently - it inhibits NNMT, which leads to higher NAD+ levels. The result is increased metabolic rate and sustained energy. It's not quite S-tier because it's more indirect in its mechanism, but the NAD+ boost alone makes it incredibly valuable for energy optimization and fat loss support.

🟡 B Tier (Very Good)

NAD+ Okay, I know - NAD+ isn't technically a peptide. But it's always included in energy stacks, and for good reason. It's fundamental for cellular energy production and stamina. It's in B-tier not because it's less effective, but because direct supplementation has bioavailability challenges compared to the peptides that boost endogenous production.

🟢 C Tier (Good, Situational)

Humanin A mitochondrial peptide with anti-apoptotic properties and metabolic support benefits. It helps with cellular energy, but it's more of a supporting player than a primary energy compound. Great for overall mitochondrial health and longevity protocols, but if energy is your main goal, the tiers above will serve you better.

I wanted to make this interactive, so let me know if you agree and drop your list below!

Available Peptides: