🔹 Who was in this trial? Adults who were obese or overweight and had knee osteoarthritis – so not a general population weight-loss study. 🔹 Dosing details Participants started at 2 mg once weekly and increased every 4 weeks until hitting 9 mg or 12 mg. These new results are based on those high doses (9–12 mg). More data is expected in 2026, including info on the planned 4 mg maintenance dose. 🔹 Weight loss: Retatrutide vs Tirzepatide - Retatrutide 12 mg: ~28.7% average body-weight reduction at 68 weeks - For reference - Tirzepatide (Zepbound) max dose: ~21–22% average weight loss at 72 weeks So yes, Retta is looking very powerful on the scale. 🔹 Side effects & discontinuations - Adverse-event–related discontinuations: - Dysesthesia (skin/nerve sensitivity) 🫀 Heart rate note: This particular trial summary didn’t mention heart rate changes at all — which is interesting, because when I tried a very low “micro” dose of Retta transitioning off tirzepatide, I personally noticed an increased resting heart rate, and with my anxiety that was a no-go. Everyone’s nervous system and tolerance is different — and Retatrutide is still investigational, not FDA approved. 📌 Education only, not medical advice. I’m a coach and educator, not a prescriber. Always work with a licensed provider before starting or changing any medication. https://investor.lilly.com/news-releases/news-release-details/lillys-triple-agonist-retatrutide-delivered-weight-loss-average

I was told that I need both peptides and collagen because of my age. I do a tasteless powder in my coffee that has both. Your thoughts??

RETA (retatrutide) talk is everywhere right now. I’ve been hearing the buzz that it could be up for FDA approval in early 2026. While the exact timing isn’t confirmed, retatrutide is still in Phase 3, with many projections pointing toward a filing around –early 2026. Either way, this drug is a big deal in the GLP-1 world. RETA is a triple agonist (GLP-1 + GIP + glucagon), which is part of why there’s so much excitement around its metabolic potential. My personal experience: I tried to switch from tirzepatide to RETA a few months ago. I started conservatively at 0.5 mg once weekly, but within about two days of the first dose I had a noticeably raised heart rate. Because I already deal with anxiety, that combo wasn’t a good mix for me. I took a break and tried again — same result. So for now, RETA just doesn’t seem to match my biology. Why this might happen: Because RETA activates the glucagon receptor, it may increase energy expenditure, and clinical data have shown dose-related increases in heart rate that researchers are still working to fully understand. Also may be longer to see full appetite suppression because of the metabolic activation. I’m sharing this to normalize something important: Even the most exciting next-gen meds aren’t one-size-fits-all. See the full chart below for some clinical data I combined :) I’d love to hear your experiences — especially if you tried it and: - loved it - couldn’t tolerate it - noticed heart rate changes or little appetite? - found a better fit staying with tirzepatide or semaglutide. (Educational discussion only — not medical advice.)

The “King of GLP-1s” Debate — My Honest Take I get this question constantly: “Is Retatrutide the new King of GLP-1s?” My answer? It’s not that simple — and it’s definitely not for everyone. Retatrutide adds a third hormone, glucagon, which can boost metabolism and energy expenditure. Tirzepatide (Mounjaro/Zepbound) works primarily on GLP-1 and GIP, which are powerful for appetite regulation and glucose control — but the added glucagon in Retatrutide can change the experience. Here’s what that can mean: - 🔥 Metabolism boost: Retatrutide may increase calorie burn. - 🍽️ Slightly less appetite suppression: Because you’re burning more, your body may feel less “satisfied” than with Tirzepatide. - ⏳ Slower onset: Many users find that appetite suppression takes longer to kick in. - ⚖️ Weight loss differences: Clinical data and anecdotal reports suggest results may appear at higher doses of Retatrutide compared to lower doses of Tirzepatide. My Personal Experience I’ve been microdosing Tirzepatide (2 mg/week) since mid-May and lost about 30 lbs. Recently, I decided to test Retatrutide (0.5 mg/week) as a way to maintain weight loss while focusing on building lean muscle — since my appetite was so low I wasn’t eating enough to fuel my workouts. My first dose of Retatrutide hit me hard: Within hours, I experienced hot sweats and a racing heart that triggered anxiety. I took two weeks off and tried again — but the same thing happened. At a family dinner, I suddenly became dizzy, flushed, and had to step outside to catch my breath. (At 41, I wondered if it was perimenopause — but I’m pretty sure it wasn’t.) So if you’re considering switching, especially if you have any heart concerns or anxiety, start low and slow — and always with medical supervision. Key Takeaway Every GLP-1 therapy works a little differently for every body. Tirzepatide has been steady, predictable, and effective for me; Retatrutide may have incredible potential for others — but it’s more complex and still being studied.

Thanksgiving on a GLP-1? You can enjoy the day without ending the night in a food coma or... guilt. 🦃✨ My simple game plan: - Lead with protein + veggies. - Go easy on the heavy hitters. Be mindful of fatty/greasy foods - your belly will thank you later! - Hydrate more than you "drink." My trick - a glass of water between a bevvie - Take a mid-plate pause. - Choose your treats on purpose. One holiday won’t make or break your progress—but how you treat your body (and talk to yourself) does matter. 🧡 Happy Thanksgiving Fam! For educational purposes only. Not medical advice.